Molecular Biology of the Cell PDF Download

Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Author: L. S. Hnilica
Publisher: CRC Press
ISBN: 1351079123
Category : Science
Languages : en
Pages : 207

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Book Description
The first volume of the Chromosomal Nonhistone Proteins treatise presents a summary of the many attempts in the literature to correlate changes in chromosomal histone proteins specificity and metabolism with transcriptional regulations in eukaryotic cells.

Author: Lubomir S. Hnilica
Publisher:
ISBN:
Category : Chromosomes
Languages : en
Pages : 216

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Author: Gary S. Stein
Publisher: CRC Press
ISBN: 9780849355158
Category : Science
Languages : en
Pages : 426

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Book Description
This comprehensive book is a compilation of Professor Lubomir S. Hnilica's twenty years of research experimentally addressing the chemistry and the biological functions of chromosomal proteins. The histones and other nuclear proteins found associated with DNA in a number of tissues and cell types are featured. Lubomir Hnilica played a major role in establishing the extent to which these basic chromosomal polypeptides are conserved and the manner in which they interact with DNA to modify chromatin structure. In addition, non-histone chromosomal protein research is explained, and his technique of applying several biochemical and immunological approaches to the characterization of this complex and heterogeneous class of chromosomal polypeptides is discussed. Highlighted is the use of chemical crosslinking for studying protein/DNA interactions in intact cells. The proteins as well as the structure, organization, and regulation of the genes are also presented.

Author: Proceedings of the National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309084458
Category : Science
Languages : en
Pages : 442

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Book Description
Over the past half-century, the central dogma, in which DNA makes RNA makes protein, has dominated thinking in biology, with continuing refinements in understanding of DNA inheritance, gene expression, and macromolecular interactions. However, we have also witnessed the elucidation of epigenetic phenomena that violate conventional notions of inheritance. Protein-only inheritance involves the transmission of phenotypes by self-perpetuating changes in protein conformation. Proteins that constitute chromatin can also transmit heritable information, for example, via posttranslational modifications of histones. Both the transmission of phenotypes via the formation of protein conformations and the inheritance of chromatin states involve self-perpetuating assemblies of proteins, and there is evidence for some common structural features and conceptual frameworks between them. To foster interactions between researchers in these two fields, the National Academy of Sciences convened an Arthur M.Sackler Colloquium entitled "Self-Perpetuating Structural States in Biology, Disease, and Genetics" in Washington, DC, on March 22-24, 2002. Participants described new phenomenology and provided insights into fundamental mechanisms of protein and chromatin inheritance. Perhaps most surprising to attendees was emerging evidence that these unconventional modes of inheritance may be common.

Author: E Johns
Publisher: Elsevier
ISBN: 0323158749
Category : Science
Languages : en
Pages : 262

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Book Description
The HMG Chromosomal Proteins focuses on various research on HMG proteins, particularly their association with active genes. Composed of literature of authors that are divided into 10 chapters, the book starts with the discussions on the history and problems in the study of chromosomal proteins. The text proceeds with the discussions on the occurrence of HMG proteins in eukaryotes; tissue specificity of HMG proteins; and species specificity and evolution of HMG proteins. The book presents techniques that are used to analyze HMG proteins and provides information on the primary structures of different proteins, such as HMG 14 and HMG 17, and the methods for cleaving these proteins. The processes involved in isolating proteins and postsynthetic modifications of their structures are noted, clarified with the study done on the HMG proteins of rainbow trout. The text ends with discussions on the association of HMG proteins with chromatin and nucleosomes and a tabulation of accumulated data. This selection is valuable for readers interested in studying HMG proteins.

Author: Trygve Tollefsbol
Publisher: Academic Press
ISBN: 0123884160
Category : Medical
Languages : en
Pages : 617

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Book Description
Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Author: Dieter Kabelitz
Publisher: Academic Press
ISBN: 0128179643
Category : Medical
Languages : en
Pages : 384

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Book Description
Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications.

Author: Kensal E. van Holde
Publisher: Springer Science & Business Media
ISBN: 1461234905
Category : Science
Languages : en
Pages : 509

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Book Description
Contemporary views on the structure and function of chromatin are presented and the history of the development of these ideas as well as the nature of the nucleic acid and protein components of chromatin are reviewed. The structure of chromatin is studied at several levels, and its modes of transcription and replication are analyzed. Chromatin provides researchers with a critical evaluation of current knowledge. It combines much information that has never before been assembled, and evaluates and interrelates it in a critical way. This has not been done before so that readers are not only provided with an overview, but with extensive references to the literature (there are about 2000 references in all).

Author: Anders Rehfeld
Publisher: Springer
ISBN: 3319418734
Category : Medical
Languages : en
Pages : 670

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Book Description
This book has been designed to help medical students succeed with their histology classes, while using less time on studying the curriculum. The book can both be used on its own or as a supplement to the classical full-curriculum textbooks normally used by the students for their histology classes. Covering the same curriculum as the classical textbooks, from basic tissue histology to the histology of specific organs, this book is formatted and organized in a much simpler and intuitive way. Almost all text is formatted in bullets or put into structured tables. This makes it quick and easy to digest, helping the student get a good overview of the curriculum. It is easy to locate specific information in the text, such as the size of cellular structures etc. Additionally, each chapter includes simplified illustrations of various histological features. The aim of the book is to be used to quickly brush up on the curriculum, e.g. before a class or an exam. Additionally, the book includes guides to distinguish between the different histological tissues and organs that can be presented to students microscopically, e.g. during a histology spot test. This guide lists the specific characteristics of the different histological specimens and also describes how to distinguish a specimen from other similar specimens. For each histological specimen, a simplified drawing and a photomicrograph of the specimen, is presented to help the student recognize the important characteristics in the microscope. Lastly, the book contains multiple “memo boxes” in which parts of the curriculum are presented as easy-to-remember mnemonics.