Principles and Practice of Modern Chromatographic Methods PDF Download

Author: Kevin Robards
Publisher: Academic Press
ISBN: 012822097X
Category : Science
Languages : en
Pages : 532

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Book Description
Principles and Practice of Modern Chromatographic Methods, Second Edition takes a comprehensive, unified approach in its presentation of chromatographic techniques. Like the first edition, the book provides a scientifically rigid, but easy-to-follow presentation of chromatography concepts that begins with the purpose and intent of chromatographic theory - the “what and why that are left out of other books attempting to cover these principles. This fully revised second edition brings the content up-to-date, covering recent developments in several new sections and an additional chapter on composite methods. New topics include sample profiling, sample preparation, sustainable green chemistry, 2D chromatography, miniaturization/nano-LC, HILIC, and more. Contains thorough chapters that begin with an updated schematic overview and a visual representation of the content Avoids the obfuscation of different terminologies and classification systems that are prevalent in the area, such as the relationship between liquid chromatography and column chromatography Provides integrated and comprehensive topic coverage based on chromatographic bibliometrics and survey reports on the relative usage of chromatographic techniques

Author: Roger-Marc Nicoud
Publisher: Cambridge University Press
ISBN: 1107082366
Category : Business & Economics
Languages : en
Pages : 675

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Book Description
A result-oriented, practical guide to key approaches, methodologies and tools for designing, modelling and simulating chromatographic processes.

Author: A. Braithwaite
Publisher: Springer Science & Business Media
ISBN: 9400940939
Category : Science
Languages : en
Pages : 422

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Book Description
In recent years the techniques of chromatography have progressed rapidly. However, the aims and objectives of the First Edition, as quoted below, are just as relevant today as they undoubtedly were in 1963. 'The various methods of separating mixtures which are grouped under the general name chromatography are now well known and widely used. Since the inception of chromatography as a column technique in 1903, the principal landmarks in its progress have been its virtual rediscovery in the 1930s, the invention of synthetic resins in 1935, the introduction of paper chromatography in the early 1940s and finally, the development of gas solid and gas liquid chromatography in the late 1940s and early 1950s. Subsequent expansion in the use of chromatographic methods has been rapid and continuous, with the result that in the last 15 years a substantial volume of literature on the subject has appeared, dealing not only with particular separations but also in much specific detail with improvements in technique.

Author: Gregory K. Webster
Publisher: CRC Press
ISBN: 042951039X
Category : Medical
Languages : en
Pages : 567

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Book Description
This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics, and vendors in the field. This book is an inclusive guide to developing all chromatographic methods (such as liquid chromatography and gas chromatography). It covers modern techniques for developing methods using chromatographic development software, requirements for validations, discussion on orthogonality, and how to transfer methods from HPLC to UHPLC. The text introduces some newer techniques that are heavily employed by chemists analyzing proteins and RNAi, as well as novel techniques such as counter current chromatography. This book is valuable for both the novice starting out in undergraduate labs and those who are new to the pharmaceutical industry and is a useful reference for seasoned analysts.

Author: R. Stock
Publisher: Springer
ISBN: 1489933603
Category : Science
Languages : en
Pages : 392

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Book Description
Classification of chromatographic methods Chromatography is the name given to a particular family of separation techniques of great effectiveness. The original method was described in 1903 by Tswett, who used it for the separation of coloured substances, and the name chromatog raphy stems from this. However, the limitation to coloured compounds never really obtained, and most chromatographic separations are nowadays performed on mixtures of colourless substances, including gases. Like fractional distillation, chromatography relies on the relative movement of two phases, but in chromatography one is fixed and is known as the stationary phase; the other is known as the mobile phase. Chromatographic methods may be classified first according to the nature of the mobile phase and, second, according to the nature of the stationary phase. The mobile phase may be a liquid or a gas, and the stationary phase may be a solid or a liquid. There are thus four main sub-divisions of the chromatographic process, as set out in Table 1.1. The system is called adsorption chromatography if the stationary phase is a solid, and partition chromatography if it is a liquid.

Author: David M. Bliesner
Publisher: John Wiley & Sons
ISBN: 0470042192
Category : Science
Languages : en
Pages : 301

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Book Description
All the information and tools needed to set up a successful method validation system Validating Chromatographic Methods brings order and Current Good Manufacturing Practices to the often chaotic process of chromatographic method validation. It provides readers with both the practical information and the tools necessary to successfully set up a new validation system or upgrade a current system to fully comply with government safety and quality regulations. The net results are validated and transferable analytical methods that will serve for extended periods of time with minimal or no complications. This guide focuses on high-performance liquid chromatographic methods validation; however, the concepts are generally applicable to the validation of other analytical techniques as well. Following an overview of analytical method validation and a discussion of its various components, the author dedicates a complete chapter to each step of validation: Method evaluation and further method development Final method development and trial method validation Formal method validation and report generation Formal data review and report issuance Templates and examples for Methods Validation Standard Operating Procedures, Standard Test Methods, Methods Validation Protocols, and Methods Validation Reports are all provided. Moreover, the guide features detailed flowcharts and checklists that lead readers through every stage of method validation to ensure success. All of the templates are also included on a supplementary support site, enabling readers to easily work with and customize them. For scientists and technicians new to method validation, this guide provides all the information and tools needed to develop a top-quality system. For those experienced with method validation, the guide helps to upgrade and improve existing systems.

Author: Raymond P.W. Scott
Publisher: CRC Press
ISBN: 1000723615
Category : Science
Languages : en
Pages : 426

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Book Description
This work introduces scientists of all disciplines to the chromatographic process and how it functions. The basic principles of chromatographic separation and specific chromatographic procedures, including gas, liquid and thin-layer chromatography, are covered. For each separation method the book details its characteristics, the instrumentation required, the procedures necessary for effective use, areas of application and examples of its use.;This work is intended for analytical chemists, laboratory technicians, and upper-level undergraduate and graduate students in analytical chemistry or separation science courses.

Author: Roger-Marc Nicoud
Publisher: Cambridge University Press
ISBN: 1316299902
Category : Technology & Engineering
Languages : en
Pages : 675

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Book Description
Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions and concepts, it builds up from the most simple to the most complex situations, including multicomponent systems, non-uniform velocity profiles, bed instability, particle size distributions, and the influence of complex environments on chromatographic process design. In addition to covering classical approaches, it introduces efficient tools for investigating chromatographic processes, such as the 'Russian-Lego' approach for linear systems, phenomenological models, and specific shortcuts for deriving the key properties of industrial processes. With an emphasis on real-world problems and applications, step-by step modeling design guidelines, and detailed exercises for self-assessment, this is a must-have guide for practitioners and researchers working in chemical, biochemical, food and pharmaceutical engineering.

Author: Roger Bertholf
Publisher: John Wiley & Sons
ISBN: 0470023104
Category : Science
Languages : en
Pages : 308

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Book Description
This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.

Author: Salvatore Fanali
Publisher: Newnes
ISBN: 0124158668
Category : Science
Languages : en
Pages : 683

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Book Description
A single source of authoritative information on all aspects of the practice of modern liquid chromatography suitable for advanced students and professionals working in a laboratory or managerial capacity Chapters written by authoritative and visionary experts in the field provide an overview and focused treatment of a single topic Each chapter emphasizes the integration of chromatographic methods and sample preparation, automation, and explains how liquid chromatography is used in different industrial sectors Focuses on expanding and illustrating the main features of the fundamental section, while demonstrating where and how the best practices of liquid chromatography are utilized Comprehensive coverage of modern liquid chromatography from theory, to methods, to selected applications Thorough selected references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision making