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Author: H.O. Klein Publisher: Springer Science & Business Media ISBN: 3642816819 Category : Medical Languages : en Pages : 138
Book Description
Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10]. Of the few drugs which are active in the advanced disease, only 5-fluorouracil (5-FU) and razoxane «±1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for long-term adjuvant treatment [2, 9]. 5-FU has been widely and intensively studied as adjuvant chemotherapy in CRC [7], but there is no unanimity that it has even the marginal influence on survival that has been claimed [3, 10]. Razoxane has not previously been tested for adjuvant or maintenance treatment in CRC. It has however a number of biological activities which might be thought useful in the treatment of residual or minimal tumours [1] and which might therefore make it useful as an adjuvant. Thus it specifically prevents tumour dissemination and metastases in some tumours and normalizes the neovasculature which the tumours induce [6, 8, 11]. The drug is not cytotoxic in the usual sense, does not affect non-dividing cells, and only blocks cell division during a brief period of the cell cycle in late G and/or early mitosis [12]. It does so non-selectively and most cells capable of 2 division examined so far have been affected by the drug. Even affected cells however are not destroyed immediately, but may increase in size and become multinucleate [5].
Author: H.O. Klein Publisher: Springer Science & Business Media ISBN: 3642816819 Category : Medical Languages : en Pages : 138
Book Description
Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10]. Of the few drugs which are active in the advanced disease, only 5-fluorouracil (5-FU) and razoxane «±1,2-bis(3,4-dioxopiperazin-1-yl)propane) are suitable for long-term adjuvant treatment [2, 9]. 5-FU has been widely and intensively studied as adjuvant chemotherapy in CRC [7], but there is no unanimity that it has even the marginal influence on survival that has been claimed [3, 10]. Razoxane has not previously been tested for adjuvant or maintenance treatment in CRC. It has however a number of biological activities which might be thought useful in the treatment of residual or minimal tumours [1] and which might therefore make it useful as an adjuvant. Thus it specifically prevents tumour dissemination and metastases in some tumours and normalizes the neovasculature which the tumours induce [6, 8, 11]. The drug is not cytotoxic in the usual sense, does not affect non-dividing cells, and only blocks cell division during a brief period of the cell cycle in late G and/or early mitosis [12]. It does so non-selectively and most cells capable of 2 division examined so far have been affected by the drug. Even affected cells however are not destroyed immediately, but may increase in size and become multinucleate [5].
Author: Theodore Hong Publisher: Springer ISBN: 3319431153 Category : Medical Languages : en Pages : 244
Book Description
This up-to-date, hands-on manual offers clear guidance on contouring and treatment planning for both standard and advanced radiation therapy in patients with gastrointestinal cancers and simultaneously draws together the available relevant clinical data for each type of cancer with a view to driving treatment recommendations. The full range of malignancies is covered, including esophageal, gastric, pancreatic, hepatic, biliary, colon, rectal, and anal cancers and pelvic recurrences. Additional chapters are devoted to stereotactic body radiation therapy (SBRT) to the liver for metastatic disease. The management of gastrointestinal cancers with radiation therapy has become increasingly complex. Specifically, the emergence of new techniques such as SBRT and intensity-modulated radiation therapy (IMRT) has further increased the need to understand how to contour targets and organs at risk, how to perform safe treatment planning, and when to apply these technologies. In this context, Radiation Therapy for Gastrointestinal Cancers represents an ideal reference for both established clinical radiation oncologists and radiation oncology residents.
Author: Tanios Bekaii-Saab, MD Publisher: Springer Publishing Company ISBN: 0826138136 Category : Medical Languages : en Pages : 516
Book Description
Handbook of Gastrointestinal Cancers is a practical guide to the management of colorectal, pancreatic, hepatocellular, gastric, and esophageal cancers as well as other cancers of the upper and lower gastrointestinal tract. Edited by a multidisciplinary group of oncologists from leading institutions, this book is an essential day-to-day reference for evidence-based treatment and patient care. The handbook focuses on treatment strategies and approaches to cancerous gastrointestinal tumors that are transforming the recent oncological landscape, including expert-given guidance on methods such as neoadjuvant and adjuvant chemotherapy, surgical transplant, radiation therapy, molecular diagnostic testing leading to molecularly targeted therapy, and immunotherapy. With so many advances in the current field, it is increasingly difficult for early-career practitioners to grasp the entirety of practices and for seasoned oncologists to keep up with newly approved therapies, side effects to treatments, and special clinical management considerations, but this handbook addresses it all. Organized by major gastrointestinal disease sites and featuring “How I Treat” case vignettes from world experts for common and uncommon management considerations, the handbook brings an experience-based perspective to these tough-to-treat areas. The treatment strategies and applications set forth in the chapters are pertinent to situations and decision-making encountered in practice. Handbook of Gastrointestinal Cancers is a valuable resource for medical oncologists, radiation oncologists, and surgeons treating and managing gastrointestinal cancers as well as trainees in medical, radiation, and surgical oncology programs needing an accessible point of care resource. KEY FEATURES: Provides treatment plans and recommendations for each stage of a range of gastrointestinal cancers, including colorectal, pancreatic, and hepatocellular cancers plus more Includes “How I Treat” patient vignettes told from the physician’s point of view within each clinical chapter Outlines special considerations for the elderly and for survivors of gastrointestinal cancers Highlights important clinical guidance on nutritional and palliative concerns commonly seen in patients with gastrointestinal cancers
Author: Suzanne Russo Publisher: Springer ISBN: 3319649000 Category : Medical Languages : en Pages : 365
Book Description
This book is a practical guide on how best to incorporate advanced radiation therapy techniques into the multimodality treatment of a wide range of gastrointestinal tumors, including esophageal cancer, gastric cancer, hepatobiliary malignancies (primary and metastatic liver tumors, intrahepatic, perihilar, and extrahepatic cholangiocarcinomas, and gallbladder cancer), pancreatic cancer, colorectal cancer, and carcinoma of the anal canal. Practical considerations when treating patients with external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, and stereotactic body radiation therapy are clearly explained. Detailed attention is devoted to the safety and efficacy of radiotherapy in combination with current and emerging systemic therapies (chemotherapy, immunotherapy, and biologic agents), surgery, and ablative therapy, and the advantages and disadvantages of alternative treatment approaches for different tumor types are carefully evaluated. The book will benefit radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, and other oncology professionals.
Author: T. Wiegel Publisher: Karger Medical and Scientific Publishers ISBN: 3805576900 Category : Science Languages : en Pages : 132
Book Description
This volume discusses diagnostic and therapeutic strategies including current controversial issues in the management of gastrointestinal tumors. Special emphasis is given to rectal and pancreatic cancer. The first part presents the latest diagnostic developments for rectal cancer with a focus on the role of preoperative radiotherapy and radio-chemotherapy. Also considered is the surgical technique of total mesorectal excision. Recurrent rectal cancer is another important issue under discussion. A large section of the book is devoted to the diagnosis and interdisciplinary treatment of pancreatic cancer. Controversies regarding the role of adjuvant radiochemotherapy are presented in detail. The final part is dedicated to the treatment of liver metastases and describes the results of surgical resection and new therapeutic approaches such as in situ ablation and radiosurgery. Offering an interdisciplinary perspective on gastrointestinal tumor therapy, this book will be of great value to surgeons and radiation oncologists. It will also be appreciated by other clinicians involved in the care of patients with gastrointestinal tumors.
Author: Ralph R., Jr. Dobelbower Publisher: Springer Science & Business Media ISBN: 3642836577 Category : Medical Languages : en Pages : 485
Book Description
Primary malignant tumors of the gastrointestinal tract account for 23% of all invasive cancers and 24% of all the deaths in 1988. In the United States, the American Cancer Society estimates that there will be 227500 new cases of gastrointestinal malignancy di agnosed, with 122350 deaths. This includes 9800 new cases of carcinomas of the esopha gus, 24800 carcinomas of the stomach, 2500 new cases of malignant tumors of the small intestine, 105000 new cases of tumors of the large intestine, and 42000 new cases of car cinoma of the rectum, 14000 new cases involving the liver and biliary passages, 27000 new cases of carcinoma of the pancreas, and 2400 other unspecified digestive tract ma lignancies. This combined incidence is second only to the number of new cases of lung cancer. Bleeding from the gastrointestinal tract represents one of the earliest findings with re gard to malignancy of the gastrointestinal tract. In general, personal or family history of colon and rectal cancer, personal or family history of polyps in the colon or rectum, or inflammatory bowel disease are high risk factors with regard to tumors in these loca tions. Dietary behavior is also important in that a diet high in fat and/or low in fiber content may be a significant causative factor.
Author: Janusz Jankowski Publisher: John Wiley & Sons ISBN: 1444300156 Category : Medical Languages : en Pages : 752
Book Description
Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach is the first evidence-based reference text designed for the multidisciplinary team of medical professionals involved in the investigation, diagnosis, and management of patients with gastrointestinal cancer. Written and edited by leading international experts in the field it sets the standard in clinical practice for dealing with esophageal, gastric, intestinal, colonic, hepatobiliary, pancreatic, and other GI tumors. The book is divided into twenty-five clinical chapters each addressing the specific cancers affecting the gastrointestinal tract. Each chapter is written by a team of authors, with each contributor specially chosen to represent a different role in the MDT. This multidisciplinary team approach reflects the current care of GI cancer patients and enables clinical decision making and patient management. All the chapters have been tried and tested in MDT meetings in leading cancer centers around the world. Gastrointestinal Oncology: A Critical Multidisciplinary Team Approach provides in-depth evidence-based knowledge and is well illustrated throughout with color photographs, line drawings, and diagrams. This authoritative and practical resource is an essential reference for the entire MDT including gastroenterologists, hepatologists, GI surgeons, medical oncologists, radiation therapists, interventional radiologists, pathologists, specialist nurses, and clinical scientists.
Author: Charles D. Blanke Publisher: Springer Science & Business Media ISBN: 3642133061 Category : Medical Languages : en Pages : 461
Book Description
Gastrointestinal Oncology is an evidence-based, practical reference intended to assist in the diagnosis and management of patients with gastrointestinal malignancies. It is designed to be as user friendly as possible and is distinguished by the extremely practical, concrete nature of the information presented and by the multidisciplinary approach adopted. In addition to disease-oriented chapters spanning sites from the esophagus to the anus, non-anatomic subjects such as modern imaging techniques are also addressed. Translational science is supplied where useful in the decision-making process. All of the authors are internationally recognized experts. This book is an ideal resource for oncologists, surgeons, gastroenterologists, and primary-care providers looking for the latest and best information on how to deal with a wide variety of gastrointestinal neoplasms.
Author: David Kelsen Publisher: Lippincott Williams & Wilkins ISBN: 9780781776172 Category : Medical Languages : en Pages : 786
Book Description
Thoroughly updated for its Second Edition, this text provides comprehensive, interdisciplinary coverage of gastrointestinal cancer, including molecular biology, diagnosis, medical, surgical, and radiation therapy, and palliative care. The initial section, Principles of Gastrointestinal Oncology, includes an expanded radiation oncology chapter, an extensively revised cancer genetics chapter, and a completely rewritten medical oncology chapter emphasizing new agents. Subsequent sections focus on esophageal, gastric, pancreatic, hepatocellular, biliary tree, and colorectal cancer. Coverage of each anatomic site includes epidemiology, screening, and prevention; molecular biology and genetics; pathology; anatomy and staging; and clinical management. The final section on uncommon cancers includes new chapters on neuroendocrine tumors and small bowel cancers. A companion Website provides instant access to the complete, fully searchable text.
Author: Ulrich Ronellenfitsch Publisher: MDPI ISBN: 3036509208 Category : Medical Languages : en Pages : 272
Book Description
Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.
Author: H.O. Klein
Author: H.O. Klein
Author: Theodore Hong
Author: Tanios Bekaii-Saab, MD
Author: Suzanne Russo
Author: T. Wiegel
Author: Ralph R., Jr. Dobelbower
Author: Janusz Jankowski
Author: Charles D. Blanke
Author: David Kelsen
Author: Ulrich Ronellenfitsch