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Author: Kownatzki Publisher: Springer ISBN: 3034888430 Category : Medical Languages : en Pages : 146
Book Description
The present volume summarizes the state of information on chemokines focussing on skin diseases. The first three chapters deal with the structure and molecular biology of chemokines and their receptors. The following three review information on the interaction of chemokines with lymphocytes, mast cells and eosinophilic granulocytes. One chapter deals with the expression of chemokines in several inflammatory skin diseases. The final chapter reports on in vitro evidence for a growth-promoting activity of chemokines in skin-derived tumor cells. The volume is of use for the basic scientist interested in practical aspects and for the physician in search for basic mechanisms of skin diseases.
Author: Kownatzki Publisher: Springer ISBN: 3034888430 Category : Medical Languages : en Pages : 146
Book Description
The present volume summarizes the state of information on chemokines focussing on skin diseases. The first three chapters deal with the structure and molecular biology of chemokines and their receptors. The following three review information on the interaction of chemokines with lymphocytes, mast cells and eosinophilic granulocytes. One chapter deals with the expression of chemokines in several inflammatory skin diseases. The final chapter reports on in vitro evidence for a growth-promoting activity of chemokines in skin-derived tumor cells. The volume is of use for the basic scientist interested in practical aspects and for the physician in search for basic mechanisms of skin diseases.
Author: R. Numerof Publisher: Springer Science & Business Media ISBN: 3540376739 Category : Medical Languages : en Pages : 225
Book Description
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Author: Kenji Kabashima Publisher: Springer ISBN: 4431558551 Category : Medical Languages : en Pages : 505
Book Description
This book reviews the role of each cell subset in the skin, providing the basics for understanding skin immunology and the mechanisms of skin diseases. The skin is one of the immune organs and is continually exposed to foreign antigens and external stimuli that must be monitored and characterized for possible elimination. Upon exposure to foreign antigens, the skin can elicit a variety of immune responses in harmony with skin components that include keratinocytes, dendritic cell subsets, mast cells, basophils, fibroblasts, macrophages, gamma-delta T cells, neutrophils, myeloid-derived suppressor cells, vascular and lymphatic cells, hair follicles, platelets, and adipose tissues, among others. In the past 10 years, knowledge of immunology has expanded drastically in areas such as innate immunity (Toll-like receptors, C-type lectins), and host defenses to bacteria and viruses, and this increased knowledge has led to the development of more effective treatment of psoriasis and other skin diseases. This book provides updates on the mechanisms of skin diseases including contact dermatitis, atopic dermatitis, psoriasis, urticaria, drug eruption, bullous diseases, anaphylaxis, graft-versus-host disease, rosacea, lymphoma, photodermatology, and collagen vascular diseases. Understanding the basics of skin immunology will help clinicians and dermatologists use new therapeutics such as biologics efficiently. Serving as an intermediary between basic science and clinical medicine, this book gives readers the opportunity to understand and marvel at the mystery and fascination of skin immunology.
Author: Kuldeep Neote Publisher: Springer Science & Business Media ISBN: 3764374373 Category : Medical Languages : en Pages : 171
Book Description
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Author: Bernhard Moser Publisher: Springer Science & Business Media ISBN: 3764374233 Category : Medical Languages : en Pages : 214
Book Description
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Author: Robert Fitridge Publisher: University of Adelaide Press ISBN: 1922064009 Category : Medical Languages : en Pages : 589
Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Jan D. Bos Publisher: Informa Healthcare ISBN: 9780849319594 Category : Medical Languages : en Pages : 824
Book Description
Top scientific authors contribute their expertise and put a wealth of complex information into perspective in Skin Immune System: Cutaneous Immunology & Clinical Immunodermatology, Third Edition. This edition provides an overview of the skin immune system (SIS), a totally updated section on immunodermatological diseases, and six new chapters. Part I presents historical and comparative information on immunodermatology and includes a new chapter on the immunogenetics of inflammatory skin disease, while Part II covers the cellular elements of SIS and highlights newly defined functional subclasses of cells. Part III describes the humoral elements of SIS and provides two new chapters which focus on defensins and cathelicidins, and on the chemokines of human skin. Part IV discusses how the cellular and humoral elements of SIS interact under different circumstances and includes a new chapter on signal transduction pathways in cutaneous immunology. Part V focuses on dermatological diseases with a significant immunological background with a new chapter on the immunology of cutaneous drug eruptions, followed by Part VI on immunotherapy in dermatology, which features a new chapter reflecting the recent wave of products from biotechnology. Since the publication of the previous editions, a great deal of significant information has become available in almost all areas of cutaneous immunology and clinical immunodermatology. This progress has now been reflected in a completely updated and expanded resource.
Author: E. Carstens Publisher: CRC Press ISBN: 1466505435 Category : Science Languages : en Pages : 482
Book Description
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Author: Kownatzki
Author: Kownatzki
Author: R. Numerof
Author: Kenji Kabashima
Author: Kuldeep Neote
Author: Bernhard Moser
Author: Robert Fitridge
Author: Jan D. Bos
Author: E. Carstens
Author: Jacoba Flier
Author: Bey Hing Goh