Journal of the National Cancer Institute PDF Download

Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 810

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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 852

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Author: Beverly Mock
Publisher: Springer Science & Business Media
ISBN: 3642500595
Category : Medical
Languages : en
Pages : 342

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The development of innovative molecular techniques such as pulse-field gel electro phoresis, cDNA subtraction libraries and chromosome hopping libraries coupled with the increasing popularity in the prospect of sequencing mammalian genomes, has triggered a resurgence of interest in finding and characterizing genes that playa role in modifying immune processes and diseases. Genetically defined strains of mice (e. g. , inbred strains and recently derived stocks of wild mice) provide ideal models for examining the genetic control of diseases as a result of their syntenic relationship with man in genetic composition as well as linkage conserva tion. Due to the relative ease of producing a specific genotype via appropriate breeding schedules, murine models may provide the only hope for unravelling those complex disease processes under mUltigenic control. This issue of CTMI is a collection of papers on the characterization and mapping of genes involved in mutations and dysregulated immune responses which produce disease phenotypes. These papers were presented at a workshop which was devoted to examining reverse genetic approaches at localizing, cloning and characterizing genes involved in a variety of developmental, autoimmune, neoplastic and infectious disease processes. In the first of three sections, a series of papers outline the most currently used methods of mapping and isolating genes whose products are unknown. The papers, following, are devoted to specific gene systems whose dysregulation is likely to produce mutant or disease phenotypes.

Author: National Cancer Institute (U.S.)
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 1092

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Author: National Cancer Institute (U.S.)
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 840

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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1860

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Author: Glenn R. Gibson
Publisher: CRC Press
ISBN: 0849381827
Category : Technology & Engineering
Languages : en
Pages : 506

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In order to achieve optimal digestion, absorption, and nutritional health, we must have appropriate populations of positive microflora. Prebiotics are functional foods that improve health by fortifying indigenous probiotics within the gut. This fast-growing area of nutrition and microbiology is rapidly amassing data and answering many questions abo

Author:
Publisher: Academic Press
ISBN: 9780128134818
Category : Science
Languages : en
Pages : 150

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Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Author: Malcolm Alison
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 736

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The Cancer Handbook provides a comprehensive overview of scientific and clinical information in cancer research and medicine (oncology). This area is one of the most intensively studied in biology and medicine, resulting in a huge amount of new information being published every year. This book summarizes and explains key facts and recent developments. It is aimed at a wide variety of readers who need easy access to knowledge concerning all major aspects of cancer biology, without too much clinical detail or specialist research material. The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment. As more and more laboratory research is applied to clinical management, e.g. the use of monoclonal antibodies as drugs, it is important that clinicians understand the aetiology of the disease and the molecular basis of the new therapeutic approaches. It is also important for laboratory scientists to appreciate the potential applications of their research and the practical issues involved in translating it to clinical practice. For this second edition, all the sections have been fully revised and updated, with new chapters addressing important topics that have gained prominence in recent years. New editors and authors have brought additional expertise to the project. For example, in the section on the Molecular and Cellular Basis of Cancer, there are new chapters on stem cells, epigenetics, and microRNAs, as well as chapters on the links between cancer and development and inflammation. In the Treatment section, the emphasis is now on multidisciplinary team management of different cancers, plus there are new chapters on clinical trial design, RNA interference and rational drug design. The page design and the quality of the diagrams has been improved, with all illustrations now in full colour. The glossary has been made more informative and easy to use.

Author: Trevor M. Penning
Publisher: Springer Science & Business Media
ISBN: 1617379956
Category : Medical
Languages : en
Pages : 447

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This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.