Characterization of Nanoparticle Suspensions Using Single Particle Inductively Coupled Plasma Mass Spectrometry PDF Download

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 29

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Author: Yongbo Dan
Publisher:
ISBN:
Category :
Languages : en
Pages : 117

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"As the rapid growing of nanotechnology, the release of engineered nanoparticles (ENPs) into the environment is inevitable. After entering the real environment, ENPs tend to react with different components of the ecosystem (e.g. water, soil, air, plants) and make their characterization difficult. Analyzing ENPs in these complex matrices still remains as a grand challenge. ENPs characterization is normally the first step of risk assessment. Current analytical techniques have shown some limitations in revealing the unique characteristics of ENPs in complex matrices and reliable analytical techniques are in urgent need. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is an emerging technique capable of determining the ENPs particle size, particle concentration and dissolved analyte concentration and has the potential to fill the analytical gap. In the presented dissertation, several SP-ICP-MS methods were developed and validated to determine the ENPs particle size, size distribution, particle concentration, and dissolved analyte concentration in complex matrices, such as sunscreens and plant tissues. An enzymatic digestion method was also developed to extract ENPs within plant tissues without causing particle dissolution for subsequent SP-ICP-MS quantification. Utilizing enzymatic digestion-SP-ICP-MS, the presence of dissolved cerium in plant shoots exposed to CeO2 NPs hydroponically was confirmed for the first time. Our results also suggest that CeO2 NPs might be taken up by plant roots as ionic cerium. Collectively, SP-ICP-MS has shown great advantages over other techniques, such as high sensitivity, tolerance of complex matrices, high throughput, and informative results (particle size, size distribution, particle concentration, and dissolved analyte concentration)"--Abstract, page iv.

Author: Anthony J. Bednar
Publisher:
ISBN:
Category : Field-flow fractionation
Languages : en
Pages : 37

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Author: Robert Thomas
Publisher: CRC Press
ISBN: 0824758838
Category : Science
Languages : en
Pages : 323

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Written by a field insider with more than 20 years of experience in the development and application of atomic spectroscopy instrumentation, the Practical Guide to ICP-MS offers key concepts and guidelines in a reader-friendly format that is superb for those with limited knowledge of the technique. This reference discusses the fundamental principles, analytical advantages, practical capabilities, and overall benefits of ICP-MS. It presents the most important selection criteria when evaluating commercial ICP-MS equipment and the most common application areas of ICP-MS such as the environmental, semiconductor, geochemical, clinical, nuclear, food, metallurgical, and petrochemical industries.

Author:
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ISBN:
Category : Nanoparticles
Languages : en
Pages : 19

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"This document specifies a method for the detection of nanoparticles in aqueous suspensions and characterization of the particle number and particle mass concentration and the number-based size distribution using ICP-MS in a time-resolved mode to determine the mass of individual nanoparticles and ionic concentrations. The method is applicable for the determination of the size of inorganic nanoparticles (e.g. metal and metal oxides like Au, Ag, TiO2, BVO4, etc.), with size ranges of 10 nm to 100 nm (and larger particles up to 1 000 nm to 2 000 nm) in aqueous suspensions. Metal compounds other than oxides (e.g. sulfides, etc.), metal composites or coated particles with a metal core can be determined if the chemical composition and density are known. Particle number concentrations that can be determined in aqueous suspensions range from 106 particles/L to 109 particles/L which corresponds to mass concentrations in the range of approximately 1 ng/L to 1 000 ng/L (for 60 nm Au particles). Actual numbers depend on the type of mass spectrometer used and the type of nanoparticle analysed. In addition to the particle concentrations, ionic concentrations in the suspension can also be determined. Limits of detection are comparable with standard ICP-MS measurements. Note that nanoparticles with sizes smaller than the particle size detection limit of the spICP-MS method may be quantified as ionic. The method proposed in this document is not applicable for the detection and characterization of organic or carbon-based nanoparticles like encapsulates, fullerenes and carbon nanotubes (CNT). In addition, it is not applicable for elements other than carbon and that are difficult to determine with ICP-MS. Reference [5] gives an overview of elements that can be detected and the minimum particle sizes that can be determined with spICP-MS." -- Page 1.

Author: Radmila Milacic
Publisher: Elsevier
ISBN: 0323853056
Category : Science
Languages : en
Pages : 452

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Analysis and Characterisation of Metal-Based Nanomaterials, Volume 93 in the Comprehensive Analytical Chemistry series, introduces recent developments in analytical methodologies for detection, characterization and quantification of metal-based nanomaterials and their applications to a variety of complex environmental, biological and food samples as well as different consumer products. Single-particle inductively coupled plasma mass spectrometry is highlighted as a powerful analytical tool for number-based concentration and size distribution, also from the metrological viewpoint. An emerging approach for the measurement of multi-metal nanoparticles by single-particle inductively coupled plasma time-of-flight mass spectrometry is discussed. Imaging of metal-based nanoparticles by hyphenated inductively coupled plasma-based techniques is also introduced. The potential of different liquid chromatography and field flow fractionation separation techniques hyphenated to inductively coupled plasma mass spectrometry is emphasized as a powerful tool in particular for complex matrices and small particles sizes. The use of different microscopic techniques for the characterization of metal-based nanoparticles and characterization of metal-based nanoparticles as contrast agents for magnetic resonance imaging are presented. Moreover, occurrence, behaviour and fate of inorganic nanoparticles in the environment is overviewed. Finally, the need for quality control standards and reference nano-materials is emphasized throughout. Presents recent developments in analytical methodologies based on mass spectrometry, light scattering and microscopic techniques for detection, characterization and quantification of metal-based nanomaterials Describes applications of the nanoparticle analysis in a variety of complex environmental, biological and food samples as well as different consumer products Provides the metrological aspects for the analysis of metal-based nanoparticles when using emerging techniques such as single-particle inductively coupled plasma mass spectrometry

Author: Jeffrey D. Clogston
Publisher: Springer Nature
ISBN: 107163786X
Category :
Languages : en
Pages : 315

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Author:
Publisher: Elsevier
ISBN: 0444643486
Category : Science
Languages : en
Pages : 200

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ICP-MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions, Volume 97 discusses trace elements and how they play an important role in biological functions and metabolism in the human body. Chapters cover Biomedical analysis by ICP-MS: A focus on single cell, Advanced statistical tools and machine learning applied to trace element analysis associated with medical conditions, ICP-MS as a tool to understand trace element homeostasis in neurological disorders, High-precision isotopic analysis of essential mineral elements – possibilities for medical diagnosis and prognosis, Exploring ICP-MS as a versatile technique: From imaging to chemical speciation, and more. Discusses the latest diagnosis/pathologies using ICP-MS analysis Covers metals, isotopes and metalorganic species for medical conditions Includes ICP-MS-based techniques

Author: Austin T. Wilson
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Growing use of engineered nanoparticles (NP) in consumer products, electronics, paints, fuels, food, supplements and medicine drives the need for analysis methods that can rapidly and accurately identify the NP composition, size, size distribution and number concentration. Single particle inductively coupled plasma mass spectrometry (sp-ICP-MS) has promise as such a method. Each nanoparticle is converted into a cloud (burst) of ions in the ICP that produces a 0.2 to ~ 1.5 ms wide signal. Calibration is required to relate the signal peak area to the mass of the NP (sensitivity) and the number of signal bursts detected to the number of NP/mL in the sample suspension (transport efficiency). However, questions remain regarding calibration methods and the accuracy and precision of the measured NP mean size, size distribution, and the number concentration. NP peak integration algorithms can end prematurely due to shot noise, resulting in erroneously low measured NP size. The sample matrix can affect the measured NP size and number concentration depending on calibration method used. When the signal produced from a NP is small (due to small NP size, low sensitivity or when measuring the edges of the ion cloud) shot noise can cause incomplete integration of the signal. Both the shape of the measured NP size distribution and the mean NP size can then be biased low. Using a modified peak detection algorithm, measured NP size distributions were similar to those measured from the same NP suspension with higher sensitivity (minimal impact of shot noise), consistent with complete NP signal peak integration. Standard NP suspensions and/or solutions are used to calibrate the transport efficiency and sensitivity (counts/fg into ICP). Some researchers reported that matrix matching the calibrants and NP sample resulted in the same measured NP size and number of particles per volume when NP or solution standards were used while others reported the opposite. The agreement between methods to measure transport efficiency varied among replicate NP suspensions and warrants further examination. When calibrants and NP samples were not matrix matched, the accuracy of the measured NP size and number concentration was degraded. When an internal standard (added to calibrants and NP samples) was used the measured NP size and number of NP/mL were more accurate. The presence of 1000 ppm Pb in a suspension of 55.8 nm Au NPs caused a 9 to 10x decrease in sensitivity and a 56% decrease in the number of NPs detected. Either both the transport efficiency and sensitivity decreased or the NP signals became too close to the detection limit. When 76.2 nm Au NPs were measured in 100 ppm Pb, the detected NP number concentration was similar to a NP suspension containing no added Pb but the measured size (69.8 nm) was biased low, consistent with a 36% decrease in sensitivity. These data suggest that either shot noise had a minimal effect on the signals from 76.2 nm Au NPs or 100 ppm Pb was not a high enough concentration to affect the transport efficiency.

Author: Ram Prasad
Publisher: Springer
ISBN: 3030165345
Category : Science
Languages : en
Pages : 290

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Book Description
Microbial Nanobionics: Volume 2, Basic Research Applications continues the important discussion of microbial nanoparticle synthesis with a focus on the mechanistic approach of biosynthesis towards nanobionics. This volume also explores the toxicity of nanomaterials in microbes and their effect on human health and the environment. Special Emphasis is given to the use of polymeric nanomaterials in smart packing for the food industry and agricultural sector. The future of nanomaterials for detection of soil microbes and their interactions and tools for environmental remedies is also comprehensively covered. The rich biodiversity of microbes make them excellent candidates for potential nanoparticle synthesis biofactories. Through a better understanding of the biochemical and molecular mechanisms of the microbial biosynthesis of metal nanoparticles, the rate of synthesis can be better developed and the monodispersity of the product can be enhanced. The characteristics of nanoparticles can be controlled via optimization of important parameters, such as temperature, pH, concentration and pressure, which regulate microbe growth conditions and cellular and enzymatic activities. Large scale microbial synthesis of nanoparticles is a sustainable method due to the non-hazardous, non-toxic and economical nature of these processes. The applications of microbial synthesis of nanoparticles are wide and varied, spanning the industrial, biomedical and environmental fields. Biomedical applications include improved and more targeted antimicrobials, biosensing, imaging and drug delivery. In the environmental fields, nanoparticles are used for bioremediation of diverse contaminants, water treatment, catalysis and production of clean energy. With the expected growth of microbial nanotechnology, this volume will serve as a comprehensive and timely reference.