![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/RJtpuAAACAAJ?fife=w150-h200)
Author: Andreas RolfsPublisher:
ISBN:
Category :
Languages : en
Pages : 28
Book Description
Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression
![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvement in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/RJtpuAAACAAJ?fife=w80-h100)
Author: Andreas RolfsCharacterization of Hypoxia-inducible Factor-1Alpha (HIF-1Alpha) and Its Involvement in Oxygen-dependent Transferrin Expression
Author: Characterization of Hypoxia-inducible Factor-1α (HIF-1α)and Its Involvement in Oxygen-dependent Transferrin Expression
Author: Andreas RolfsCharacterization of Hypoxia-inducible Factor-1a (HIF-1a) and Its Involvement in Oxygen-dependent Transferrin Expression
Author: Andreas RolfsCharacterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvemnet in Oxygen-dependent Transferrin Expression
![Characterization of Hypoxia-inducible Factor-1[alpha] (HIF-1[alpha]) and Its Involvemnet in Oxygen-dependent Transferrin Expression PDF](https://books.google.com/books/content/images/frontcover/W9xwNwAACAAJ?fife=w80-h100)
Author: Andreas RolfsHypoxia-inducible Factor-1 Alpha (HIF-1alpha) and Its Role in the Hypoxic Preconditioning and Gene Expression Patterns in Zebrafish ( Danio Rerio) Embryos
Author: Amira F. MohamedPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Preconditioning to lowered oxygen levels (hypoxia) may occur when an animal is subjected to non-lethal levels of hypoxia and then returned to normoxic conditions. During a subsequent exposure to hypoxia, the pre-exposed animals may exhibit increased tolerance compared to naive animals. I have demonstrated, by analysis of critical PO2's (Pcrit), that zebrafish embryos can be preconditioned to hypoxia. Preconditioned embryos display a lower Pcrit than controls, indicating a heightened ability to endure hypoxic conditions. The role of the hypoxia inducible factor-1 (HIF-1) in promoting hypoxic preconditioning was examined. To determine the role of HIF-1 in preconditioning, embryos deficient in HIF-1alpha (using antisense oligonucleotide morpholinos) were assessed under hypoxic conditions. No significant difference between preconditioning capacities of control- and HIF-1alpha deficient embryos was observed. In addition to assessing Pcrit, a suite of hypoxia responsive genes were analysed by real time PCR. IGFBP-2 showed a significant decrease in expression in the HIF-1alpha deficient embryos, and EPO showed a significant increase in HIF-1alpha deficient embryos. All other genes examined showed no significant change between treated and control embryos.
Stress-Inducible Cellular Responses
Author: U. FeigePublisher: Birkhäuser
ISBN: 3034890885
Category : Science
Languages : en
Pages : 487
Book Description
This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.
Oxygen Sensing
Author: Publisher: Elsevier
ISBN: 0080497195
Category : Science
Languages : en
Pages : 867
Book Description
The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.
Hypoxia
Author: Robert C. RoachPublisher: Springer Science & Business Media
ISBN: 9780306466960
Category : Medical
Languages : en
Pages : 466
Book Description
Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Smart Materials Fabrication and Materials for Micro-Electro-Mechanical Systems: Volume 276
Author: A. Peter JardinePublisher:
ISBN:
Category : Technology & Engineering
Languages : en
Pages : 344
Book Description
The MRS Symposium Proceeding series is an internationally recognised reference suitable for researchers and practitioners.