Author: Paul Tomlins
Publisher: Elsevier
ISBN: 1782420959
Category : Technology & Engineering
Languages : en
Pages : 296
Book Description
Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
Characterisation and Design of Tissue Scaffolds
Author: Paul Tomlins
Publisher: Elsevier
ISBN: 1782420959
Category : Technology & Engineering
Languages : en
Pages : 296
Book Description
Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
Publisher: Elsevier
ISBN: 1782420959
Category : Technology & Engineering
Languages : en
Pages : 296
Book Description
Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
Characterization of Biomaterials
Author: Julia Will
Publisher: Elsevier Inc. Chapters
ISBN: 0128071028
Category : Science
Languages : en
Pages : 20
Book Description
In order to enhance the application potential of scaffolds in tissue engineering, comprehensive characterization of scaffold micro- and macro-structure, porosity, permeability and mechanical properties are required. In addition, before in vivo studies can be carried out, a complete assessment of the in vitro behavior of scaffolds, e.g. in selected cell culture studies, is required. The present chapter revises the wide range of methods applied to characterize scaffolds and emphasizes the need for a combination of different characterization techniques for understanding scaffold performance required for successful bone regeneration.
Publisher: Elsevier Inc. Chapters
ISBN: 0128071028
Category : Science
Languages : en
Pages : 20
Book Description
In order to enhance the application potential of scaffolds in tissue engineering, comprehensive characterization of scaffold micro- and macro-structure, porosity, permeability and mechanical properties are required. In addition, before in vivo studies can be carried out, a complete assessment of the in vitro behavior of scaffolds, e.g. in selected cell culture studies, is required. The present chapter revises the wide range of methods applied to characterize scaffolds and emphasizes the need for a combination of different characterization techniques for understanding scaffold performance required for successful bone regeneration.
Development and Characterisation of Completely Degradable Composite Tissue Engineering Scaffolds
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
ABSTRACT The field of Tissue Engineering has developed in response to the shortcomings associated to the replacement of tissues lost to disease or trauma: donor tissue rejection, chronic inflammation, and donor tissue shortages. The driving force behind Tissue Engineering is to avoid these problems by creating biological substitutes capable of replacing the damaged tissue. This is done by combining scaffolds, cells and signals in order to create living, physiological, three-dimensional tissues. Scaffolds are porous biodegradable structures that are meant to be colonised by cells and degrade in time with tissue generation. Scaffold design and development is mainly an engineering challenge, and is the goal of this PhD thesis. The main aim of this thesis is to develop and characterise scaffolds for Tissue Engineering applications. Specifically, its objectives are: 1. To study, optimise and characterise two scaffold processing methods: Solvent Casting and Phase Separation. This is done by experiment design analysis. 2. To characterise the degradation, surface properties, and cellular behaviour of the scaffolds produced. The scaffolds are made of a composite of polylactic acid polymer and a calcium phosphate soluble glass. The comparison of the two processing methods reveals that in general, the solvent cast scaffolds have higher porosities and lower mechanical properties than the phase-separated ones. Two compositions containing 20 weight % and 50 weight % of glass particles were chosen for further characterisations including degradation, surface properties and cellular behaviour. The degradation of the scaffolds was studied for a period of 10 weeks. The evolution of various parameters such as: morphology, weight loss, mechanical properties, thermal transitions and porosity, was monitored. Scaffolds produced via solvent casting were found to be more severely affected by degradation than phase-separated ones. The surface properties of the scaffolds were measured by model.
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
ABSTRACT The field of Tissue Engineering has developed in response to the shortcomings associated to the replacement of tissues lost to disease or trauma: donor tissue rejection, chronic inflammation, and donor tissue shortages. The driving force behind Tissue Engineering is to avoid these problems by creating biological substitutes capable of replacing the damaged tissue. This is done by combining scaffolds, cells and signals in order to create living, physiological, three-dimensional tissues. Scaffolds are porous biodegradable structures that are meant to be colonised by cells and degrade in time with tissue generation. Scaffold design and development is mainly an engineering challenge, and is the goal of this PhD thesis. The main aim of this thesis is to develop and characterise scaffolds for Tissue Engineering applications. Specifically, its objectives are: 1. To study, optimise and characterise two scaffold processing methods: Solvent Casting and Phase Separation. This is done by experiment design analysis. 2. To characterise the degradation, surface properties, and cellular behaviour of the scaffolds produced. The scaffolds are made of a composite of polylactic acid polymer and a calcium phosphate soluble glass. The comparison of the two processing methods reveals that in general, the solvent cast scaffolds have higher porosities and lower mechanical properties than the phase-separated ones. Two compositions containing 20 weight % and 50 weight % of glass particles were chosen for further characterisations including degradation, surface properties and cellular behaviour. The degradation of the scaffolds was studied for a period of 10 weeks. The evolution of various parameters such as: morphology, weight loss, mechanical properties, thermal transitions and porosity, was monitored. Scaffolds produced via solvent casting were found to be more severely affected by degradation than phase-separated ones. The surface properties of the scaffolds were measured by model.
The Design, Manufacture and Characterisation of Polycaprolactone Scaffolds and a Novel Modular Perfusion Bioreactor Strategy for Bone Tissue Engineering
Author: Peter John Christopher Felstead
Publisher:
ISBN:
Category : Bone regeneration
Languages : en
Pages : 262
Book Description
Publisher:
ISBN:
Category : Bone regeneration
Languages : en
Pages : 262
Book Description
Design, Fabrication and Characterization of Biodegradable Scaffolds for Tissue Engineering and Regenerative Medicine Applications
Author: Muhammad Anwaar Nazeer
Publisher:
ISBN:
Category : Biodegradation
Languages : en
Pages : 280
Book Description
Publisher:
ISBN:
Category : Biodegradation
Languages : en
Pages : 280
Book Description
Fabrication and Characterisation of Scaffolds for Bone Tissue Engineering
Design, Fabrication, and Characterization of Poly-[epsilon]-caprolactone Tissue Scaffolds
Author: Andrew Ryan Thoreson
Publisher:
ISBN:
Category : Biodegradable plastics
Languages : en
Pages : 198
Book Description
Publisher:
ISBN:
Category : Biodegradable plastics
Languages : en
Pages : 198
Book Description
Computer Aided Design and Characterization of Optimal Biomorphic Scaffolds for Tissue Engineering
Author: Srinivasan Rajagopalan
Publisher:
ISBN:
Category :
Languages : en
Pages : 370
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 370
Book Description
Fabrication and Characterisation of 3 Dimensional Scaffold for Tissue Engineering Application Via Microstereolithography Technique
Author: Marina Talib
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Microstereolithography is a method used for rapid prototyping of polymeric and ceramic components. This technique converts a computer-aided design (CAD) to a three dimensional (3D) model, and enables layer-per-layer fabrication curing a liquid resin with UV-light or laser source. However, the use of stereolithography in tissue engineering has not been significantly explored possibly due to the lack of commercially available implantable or biocompatible materials from the SL industry. This thesis seeks to develop a range of new bio-compatible/degradable materials that are compatible with a commercial 3D direct manufacture system (envisionTEC Desktop). Firstly, development and modification of microstereolithography equipments were undertaken in order to allow some understanding on the techniques and the process involved in microstereolithography technique. Secondly, a selection of multifunctional polymer and calcium phosphate were studied in order to formulate biodegradable photopolymer resin for specific tissue engineering applications. A 3D structure was successfully fabricated from the formulated photocurable resins. They were then sintered at high temperature for polymer removal, to obtain a ceramic of the desired porosity. Mechanical properties, morphology and calcium phosphate content of the sintered polymers were characterised and investigated with SEM and XRD, respectively. The addition of calcium phosphate coupled with high temperature sintering, had a significant effect on the mechanical properties exhibited by the bioceramic. The successful fabrication of novel bioceramic polymer composite with MSL technique offers the possibility of designing complex tissue scaffolds with optimum mechanical properties for specific tissue engineering applications.
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Microstereolithography is a method used for rapid prototyping of polymeric and ceramic components. This technique converts a computer-aided design (CAD) to a three dimensional (3D) model, and enables layer-per-layer fabrication curing a liquid resin with UV-light or laser source. However, the use of stereolithography in tissue engineering has not been significantly explored possibly due to the lack of commercially available implantable or biocompatible materials from the SL industry. This thesis seeks to develop a range of new bio-compatible/degradable materials that are compatible with a commercial 3D direct manufacture system (envisionTEC Desktop). Firstly, development and modification of microstereolithography equipments were undertaken in order to allow some understanding on the techniques and the process involved in microstereolithography technique. Secondly, a selection of multifunctional polymer and calcium phosphate were studied in order to formulate biodegradable photopolymer resin for specific tissue engineering applications. A 3D structure was successfully fabricated from the formulated photocurable resins. They were then sintered at high temperature for polymer removal, to obtain a ceramic of the desired porosity. Mechanical properties, morphology and calcium phosphate content of the sintered polymers were characterised and investigated with SEM and XRD, respectively. The addition of calcium phosphate coupled with high temperature sintering, had a significant effect on the mechanical properties exhibited by the bioceramic. The successful fabrication of novel bioceramic polymer composite with MSL technique offers the possibility of designing complex tissue scaffolds with optimum mechanical properties for specific tissue engineering applications.
New Developments in Tissue Engineering and Regeneration
Author: Paulo Rui Fernandes
Publisher: Springer
ISBN: 303015372X
Category : Technology & Engineering
Languages : en
Pages : 86
Book Description
This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds. The multidisciplinary character of this field has motivated contributions from different areas with a common objective to replace damaged tissues and organs by healthy ones. This work treats tissue healing approaches, mathematic modelling for scaffold design and bio fabrication methods, giving the reader a broad view of the state of the art in Tissue Engineering. The present book contains contributions from recognized researchers in the field, who were keynote speakers in the Fourth International Conference on Tissue Engineering, held in Lisbon in 2015, and covering different aspects of Tissue Engineering. The book is strongly connected with the conference series of ECCOMAS Thematic Conferences on Tissue Engineering, an event that brings together a considerable number of researchers from all over the world, representing several fields of study related to Tissue Engineering.
Publisher: Springer
ISBN: 303015372X
Category : Technology & Engineering
Languages : en
Pages : 86
Book Description
This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds. The multidisciplinary character of this field has motivated contributions from different areas with a common objective to replace damaged tissues and organs by healthy ones. This work treats tissue healing approaches, mathematic modelling for scaffold design and bio fabrication methods, giving the reader a broad view of the state of the art in Tissue Engineering. The present book contains contributions from recognized researchers in the field, who were keynote speakers in the Fourth International Conference on Tissue Engineering, held in Lisbon in 2015, and covering different aspects of Tissue Engineering. The book is strongly connected with the conference series of ECCOMAS Thematic Conferences on Tissue Engineering, an event that brings together a considerable number of researchers from all over the world, representing several fields of study related to Tissue Engineering.