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Changing Views of the Evolution of Immunity

Changing Views of the Evolution of Immunity PDF Author: Gary W. Litman
Publisher: Frontiers E-books
ISBN: 2889191710
Category :
Languages : en
Pages : 131

Book Description
The multitude of cells, signaling pathways, receptors, novel genetic recombination mechanisms and interactive pathways of receptor function and cell differentiation that constitute the vertebrate adaptive immune system are integrally linked with the multicomponent innate immune system. At first glance, the levels of complexity seen in both systems at the phylogenetic level of mammals present what seem to be insurmountable hurdles in terms of achieving a systematic understanding of the evolution of immunity. New research directions and approaches suggest that resolution of many long-standing questions in this area is now possible. Historically, immunologists considered lower vertebrates and invertebrates as “simpler” forms, i.e., they were expected to possess more basic (less layered) levels of immunological complexity and thus potentially would serve as important resources. By considering the systematic placement of representative species in the context of phylogeny, characterizing their immune receptors, co-receptors as well as accessory molecules and evaluating responses to immunologic stimuli, it was thought that a clearer picture of immune evolution would emerge. There is no doubt that this approach has achieved some notable successes but for the most part it has fallen short in terms of achieving a broad understanding of the immunologic needs of many relevant models and how adaptive change in immune function is effected. Even if a structurally relevant ortholog of an immune effector is identified in a model organism, there is no reason to assume that it functions in a corresponding manner in disparate phylogenetic taxa. For example, survival of a sessile marine invertebrate, whose anatomical form puts it in open and contiguous contact with a literal sea of microorganisms and viruses, would be thought to depend, at least in part, on a “capable” immune response; however, at present, we have no real understanding of how this is achieved in an integrated manner. Furthermore, questions arise as to whether or not phenomena that are considered integral components of vertebrate-type immunity such as memory, tolerance, somatic change and clonal selection exist in invertebrates and if their functions parallel those recognized in mammals. More often than not, our interpretations are guided by preconceived notions that are based on observations made in distant species that often do not apply to far- removed taxa. We anticipate that major advances in our understanding of this broad subject are now forthcoming as resources exist or are being developed for examining important model organisms in their natural environments instead of within the confines of in vitro systems of potentially remote physiological significance. Taking a wide range of hypotheses, observations and interpretations into account, in this special topic, contributors have developed a comprehensive overview emphasizing new directions and interpretations for understanding basic aspects of immunity that consider unique features inherent to various model systems, their life histories and habitats. Approaches applied with key model organisms maintained and confronted with relevant challenges under natural conditions are emphasized. Current concepts of self and nonself are addressed not only in terms of immunity but also reproductive fitness. How genetic variation in immune effector molecules is achieved and maintained in natural populations is examined; particular attention is directed to response interfaces that factor in symbiotic interactions. Gene expansion and mechanisms of genetic diversification are explored. How diverse molecules and a variety of effector cells contribute to our broad understanding of the evolution of a remarkably complex, integrated system and how this work is facilitating our understanding of mammalian immunity is addressed.

Changing Views of the Evolution of Immunity

Changing Views of the Evolution of Immunity PDF Author: Gary W. Litman
Publisher: Frontiers E-books
ISBN: 2889191710
Category :
Languages : en
Pages : 131

Book Description
The multitude of cells, signaling pathways, receptors, novel genetic recombination mechanisms and interactive pathways of receptor function and cell differentiation that constitute the vertebrate adaptive immune system are integrally linked with the multicomponent innate immune system. At first glance, the levels of complexity seen in both systems at the phylogenetic level of mammals present what seem to be insurmountable hurdles in terms of achieving a systematic understanding of the evolution of immunity. New research directions and approaches suggest that resolution of many long-standing questions in this area is now possible. Historically, immunologists considered lower vertebrates and invertebrates as “simpler” forms, i.e., they were expected to possess more basic (less layered) levels of immunological complexity and thus potentially would serve as important resources. By considering the systematic placement of representative species in the context of phylogeny, characterizing their immune receptors, co-receptors as well as accessory molecules and evaluating responses to immunologic stimuli, it was thought that a clearer picture of immune evolution would emerge. There is no doubt that this approach has achieved some notable successes but for the most part it has fallen short in terms of achieving a broad understanding of the immunologic needs of many relevant models and how adaptive change in immune function is effected. Even if a structurally relevant ortholog of an immune effector is identified in a model organism, there is no reason to assume that it functions in a corresponding manner in disparate phylogenetic taxa. For example, survival of a sessile marine invertebrate, whose anatomical form puts it in open and contiguous contact with a literal sea of microorganisms and viruses, would be thought to depend, at least in part, on a “capable” immune response; however, at present, we have no real understanding of how this is achieved in an integrated manner. Furthermore, questions arise as to whether or not phenomena that are considered integral components of vertebrate-type immunity such as memory, tolerance, somatic change and clonal selection exist in invertebrates and if their functions parallel those recognized in mammals. More often than not, our interpretations are guided by preconceived notions that are based on observations made in distant species that often do not apply to far- removed taxa. We anticipate that major advances in our understanding of this broad subject are now forthcoming as resources exist or are being developed for examining important model organisms in their natural environments instead of within the confines of in vitro systems of potentially remote physiological significance. Taking a wide range of hypotheses, observations and interpretations into account, in this special topic, contributors have developed a comprehensive overview emphasizing new directions and interpretations for understanding basic aspects of immunity that consider unique features inherent to various model systems, their life histories and habitats. Approaches applied with key model organisms maintained and confronted with relevant challenges under natural conditions are emphasized. Current concepts of self and nonself are addressed not only in terms of immunity but also reproductive fitness. How genetic variation in immune effector molecules is achieved and maintained in natural populations is examined; particular attention is directed to response interfaces that factor in symbiotic interactions. Gene expansion and mechanisms of genetic diversification are explored. How diverse molecules and a variety of effector cells contribute to our broad understanding of the evolution of a remarkably complex, integrated system and how this work is facilitating our understanding of mammalian immunity is addressed.

Host and Microbe Adaptations in the Evolution of Immunity

Host and Microbe Adaptations in the Evolution of Immunity PDF Author: Larry J. Dishaw
Publisher: Frontiers Media SA
ISBN: 2889630226
Category :
Languages : en
Pages : 254

Book Description
The evolution of metazoans has been accompanied by new interfaces with the microbial environment that include biological barriers and surveillance by specialized cell types. Increasingly complex organisms require increased capacities to confront pathogens, achieved by co-evolution of recognition mechanisms and regulatory pathways. Two distinct but interactive forms of immunity have evolved. Innate immunity, shared by all metazoans, is traditionally viewed as simple and non-specific. Adaptive immunity possesses the capacity to anticipate new infectious challenges and recall previous exposures; the most well-understood example of such a system, exhibited by lymphocytes of vertebrates, is based on somatic gene alterations that generate extraordinary specificity in discrimination of molecular structures. Our understanding of immune phylogeny over the past decades has tried to reconcile immunity from a vertebrate standpoint. While informative, such approaches cannot completely address the complex nature of selective pressures brought to bear by the complex microbiota (including pathogens) that co-exist with all metazoans. In recent years, comparative studies (and new technologies) have broadened our concepts of immunity from a systems-wide perspective. Unexpected findings, e.g., genetic expansions of innate receptors, high levels of polymorphism, RNA-based forms of generating diversity, adaptive evolution and functional divergence of gene families and the recognition of novel mediators of adaptive immunity, prompt us to reconsider the very nature of immunity. Even fundamental paradigms as to how the jawed vertebrate adaptive immune system should be structured for “optimal” recognition potential have been disrupted more than once (e.g., the discovery of the multicluster organization and germline joining of immunoglobulin genes in sharks, gene conversion as a mechanism of somatic diversification, absence of IgM or MHC II in certain teleost fishes). Mechanistically, concepts of innate immune memory, often referred to as “trained memory,” have been realized further, with the development of new discoveries in studies of epigenetic regulation of somatic lineages. Immune systems innovate and adapt in a taxon-specific manner, driven by the complexity of interactions with microbial symbionts (commensals, mutualists and pathogens). Immune systems are shaped by selective forces that reflect consequences of dynamic interactions with microbial environments as well as a capacity for rapid change that can be facilitated by genomic instabilities. We have learned that characterizing receptors and receptor interactions is not necessarily the most significant component in understanding the evolution of immunity. Rather, such a subject needs to be understood from a more global perspective and will necessitate re-consideration of the physical barriers that afford protection and the developmental processes that create them. By far, the most significant paradigm shifts in our understanding of immunity and the infection process has been that microbes no longer are considered to be an automatic cause or consequence of illness, but rather integral components of normal physiology and homeostasis. Immune phylogeny has been shaped not only by an arms race with pathogens but also perhaps by mutualistic interactions with resident microbes. This Research Topic updates and extends the previous eBook on Changing Views of the Evolution of Immunity and contains peer-reviewed submissions of original research, reviews and opinions.

Immunity to Change

Immunity to Change PDF Author: Robert Kegan
Publisher: Harvard Business Press
ISBN: 1422129470
Category : Business & Economics
Languages : en
Pages : 340

Book Description
Unlock your potential and finally move forward. A recent study showed that when doctors tell heart patients they will die if they don't change their habits, only one in seven will be able to follow through successfully. Desire and motivation aren't enough: even when it's literally a matter of life or death, the ability to change remains maddeningly elusive. Given that the status quo is so potent, how can we change ourselves and our organizations? In Immunity to Change, authors Robert Kegan and Lisa Lahey show how our individual beliefs--along with the collective mind-sets in our organizations--combine to create a natural but powerful immunity to change. By revealing how this mechanism holds us back, Kegan and Lahey give us the keys to unlock our potential and finally move forward. And by pinpointing and uprooting our own immunities to change, we can bring our organizations forward with us. This persuasive and practical book, filled with hands-on diagnostics and compelling case studies, delivers the tools you need to overcome the forces of inertia and transform your life and your work.

Janeway's Immunobiology

Janeway's Immunobiology PDF Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :

Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Molecular Biology of The Cell

Molecular Biology of The Cell PDF Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0

Book Description


Evolutionary Concepts in Immunology

Evolutionary Concepts in Immunology PDF Author: Robert Jack
Publisher: Springer
ISBN: 3030186679
Category : Medical
Languages : en
Pages : 145

Book Description
Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge.

The Past and the Future of Human Immunity Under Viral Evolutionary Pressure

The Past and the Future of Human Immunity Under Viral Evolutionary Pressure PDF Author: Gkikas Magiorkinis
Publisher: Frontiers Media SA
ISBN: 2889632296
Category :
Languages : en
Pages : 186

Book Description
There is a long-standing evolutionary battle between viruses and their hosts that continues to be waged. The evidence of this conflict can be found on both sides, with the human immune system being responsive to new viral challenges and viruses having developed often sophisticated countermeasures. The “arms race” between viruses and hosts can be thought as an example of the “Red Queen” race, an evolutionary hypothesis inspired from the dialogue of Alice with the Red Queen in Lewis Carroll’s “Through the Looking-Glass”. At the same time, viruses have a minimal genomic content as they have evolved to hitchhike biological machinery of their hosts (or other co-infecting viruses). The minimalistic viral genome could be thought as the result of a “Black Queen” evolution, a theory inspired from the card game Heart, where the winner is the one with the fewest points at the end. The effects of this arms race are evident in the evolution of the human immune system. This system is capable of responding to diverse viral challenges, utilizing both the ancient innate immune system and the more recently evolved adaptive immune system of jawed vertebrates. It is now well-known that the two systems are linked, with innate immunity hypothesized to have provided raw material for the emergence of the adaptive immune response. The adaptive immune response comprises several protein families (including B and T cell receptors, MHC and KIR proteins, for example) that are encoded by complex and variable genomic regions. This complexity enables for responsive genetic changes to occur in immune cells, such as the ability of genomic hypervariable regions in B cells to recombine in order to produce more specific antibodies. Indeed, the human immune system is thought to be continually evolving via various mechanisms such as changes in the genes encoding immune receptors and the regulatory sequences that control their expression. For example, there is some evidence that exogenous viral infections can alter the expression of endogenous retroviruses, some of which contribute to the immune response. Viral countermeasures can include encoding decoy receptors for the signalling molecules of the immune response, altering the gene expression of adaptive immune cells during chronic infection or using host enzymes to facilitate viral immune escape. As the articles herein show, the immune system continues to be challenged by viral infections and these challenges continue to shape how the immune system combats pathogens, thus viruses and human immunity are continuously part of “Red and Black Queen” evolutionary dynamics. We had the pleasure of working with Jonas Blomberg as a reviewer during the course of the Research Topic and his untimely passing was a great loss. Prof. Blomberg made significant contributions, including to the nomenclature of endogenous retroviruses (ERVs), the evolution and characterization of specific human ERV (HERV) and the contribution of ERVs to diseases such as cancer. It is with great respect for his contributions to the ERV field that we dedicate this eBook to his memory.

Immunology and Evolution of Infectious Disease

Immunology and Evolution of Infectious Disease PDF Author: Steven A. Frank
Publisher: Princeton University Press
ISBN: 9780691095950
Category : Medical
Languages : en
Pages : 364

Book Description
Publisher Description

The Evolution of the Immune System

The Evolution of the Immune System PDF Author: Davide Malagoli
Publisher: Academic Press
ISBN: 012802013X
Category : Medical
Languages : en
Pages : 384

Book Description
The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization Brings concepts and ideas on the evolution of the immune system to a wide readership

The Causes of Evolution

The Causes of Evolution PDF Author: John Burdon Haldane
Publisher: Princeton University Press
ISBN: 9780691024424
Category : Science
Languages : en
Pages : 256

Book Description
J.B.S. Haldane (1892-1964), one of the founders of the science of population genetics, was also one of the greatest practitioners of the art of explaining science to the layperson. Haldane was a superb story-teller, as his essays and his children's books attest. In The Causes of Evolution he not only helped to marry the new science of genetics to the older one of evolutionary theory but also provided an accessible introduction to the genetical basis of evolution by natural selection. Egbert Leigh's new introduction to this classic work places it in the context of the ongoing study of evolution. Describing Haldane's refusal to be confined by a "System" as a "light-hearted" one, Leigh points out that we are now finding that "Haldane's questions are the appropriate next stage in learning how adaptation can evolve. We are now ready to reap the benefit of the fact that Haldane was a free man in the sense that really matters."