Cerebrovascular Pathology in Alzheimer's Disease PDF Download

Author: Jack C. De La Torre
Publisher:
ISBN: 9781573310871
Category : Alzheimer's disease
Languages : en
Pages : 523

View

Book Description
Do changes in the cerebrovascular system precede or follow clinical onset of Alzheimer's Disease? In this book a distinguished group of contributors addressES this question and explores the extent to which the pathological changes found in the brains of p

Author: Jack C. De La Torre
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 552

View

Book Description
The pathogenesis and progression of Alzheimer's disease is examined from the less-usual vantage point of the dysfunctional cerebrovasculature on amyloid formation, loss of neuronal homeostasis, synaptic changes, metabolic compromise, and cognitive decline. The book explores whether the cerebrovascular changes precede or follow clinical onset of the disease and the extent to which the pathological changes found in the brains of patients with Alzheimer's disease are related to cerebral blood flow, perfusion, and blood-brain barrier dysfunction.

Author: M.M. Verbeek
Publisher: Springer Science & Business Media
ISBN: 9780792363668
Category : Medical
Languages : en
Pages : 400

View

Book Description
Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

Author: Stefano Govoni
Publisher: Springer
ISBN: 9783030280079
Category : Medical
Languages : en
Pages : 0

View

Book Description
This ambitious and comprehensive handbook represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, the book presents a variety of perspectives on the core topic: from social and philosophical to gender-related aspects. It is designed for a broad readership and includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.

Author: David Libon
Publisher: Oxford University Press, USA
ISBN: 0190634235
Category : Medical
Languages : en
Pages : 505

View

Book Description
"Cerebrovascular and Alzheimer disease often occur together, but are usually studied apart. This book offers a timely integrated approach to both diseases. Beginning with a section on epidemiology and neuropsychology, this volume goes on to discuss and explore the neuropathological and neurophysiological mechanisms of these disorders. This book then develops a novel concept of an Alzheimer disease/vascular dementia spectrum. Sections on neuroimaging, as well as treatments and interventions follow. The editors have succeeded in gathering an impressive group of clinicians and scientists, who are well qualified by their achievements and leadership to make important contributions to this new integrated approach to dementing disorders. This important book should have broad appeal to anyone studying or caring for patients with dementing disorders, as it is comprehensive, yet focused on a unitary, complementary and pragmatic approach"--

Author: Alexander Hartmann
Publisher: Springer Science & Business Media
ISBN: 3642762085
Category : Medical
Languages : en
Pages : 460

View

Book Description
In contrast to dementia of the Alzheimer type, the subject of dementia subsequent to cerebral ischemia has been discussed rather rarely. Now this book provides a summary of the brain morphology, neurochemistry and clinical aspects of dementia subsequent to cerebral ischemia. The contributions discuss the similarities and differences between the two predominant dementia types. The broad range of aspects cover 1) the morphology and morphobiology of brain tissue during aging and under the two pathological condi- tions, 2) the neuropathochemistry of post mortem brain tissue of patients as well as brain tissue from experimental animals, 3) CSF changes during aging and in dementia states and 4) clinical research, mainly using brain imaging tech- niques to differentiate between dementia types and to find a basis for rational therapeutic approaches.

Author: Elizabeth Head
Publisher: Academic Press
ISBN: 0128188464
Category : Medical
Languages : en
Pages : 354

View

Book Description
The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. - Discusses the complexities involved with aging and Alzheimer's disease in Down syndrome - Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age - Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Author: Robert H. Paul
Publisher: Springer Science & Business Media
ISBN: 1592598242
Category : Medical
Languages : en
Pages : 344

View

Book Description
A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

Author: Jack C. De La Torre
Publisher:
ISBN:
Category : Alzheimer's disease
Languages : en
Pages : 0

View

Book Description

Author: Veronica Lifshitz
Publisher:
ISBN:
Category :
Languages : en
Pages : 118

View

Book Description