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Author: F DeFeudis Publisher: Elsevier ISBN: 0323159559 Category : Medical Languages : en Pages : 236
Book Description
Central Cholinergic Systems and behavior reviews experimental evidence on the possible involvement of central cholinergic systems in the regulation of animal behavior. More specifically, the book investigates the role of acetylcholine as a transmitter in the mammalian spinal cord and in central nervous function. This text also describes cholinergic involvement in some of the more fundamental processes of central nervous functions and how it may fit into overall cholinergic and non-cholinergic behavioral patterns. This book is organized into seven chapters and begins with an overview of the link between central cholinergic mechanisms and behavior, and then discusses the cholinergic roles in consciousness, emphasizing on the roles of reticular systems in the arousal mechanism. An effort is made to define the cholinergic nature of some spinal mechanisms that are apparently involved in reflexes and posture. An account of the role of cholinergic mechanisms in central respiratory control is also given, along with the function of acetylcholine as an important transmitter at many sites of the central nervous system. The book concludes by analyzing the roles of cholinergic systems in motivated behaviors, emotion, learning, and memory. This book is a valuable resource for students and researchers in fields ranging from physiology to biology and psychiatry.
Author: F DeFeudis Publisher: Elsevier ISBN: 0323159559 Category : Medical Languages : en Pages : 236
Book Description
Central Cholinergic Systems and behavior reviews experimental evidence on the possible involvement of central cholinergic systems in the regulation of animal behavior. More specifically, the book investigates the role of acetylcholine as a transmitter in the mammalian spinal cord and in central nervous function. This text also describes cholinergic involvement in some of the more fundamental processes of central nervous functions and how it may fit into overall cholinergic and non-cholinergic behavioral patterns. This book is organized into seven chapters and begins with an overview of the link between central cholinergic mechanisms and behavior, and then discusses the cholinergic roles in consciousness, emphasizing on the roles of reticular systems in the arousal mechanism. An effort is made to define the cholinergic nature of some spinal mechanisms that are apparently involved in reflexes and posture. An account of the role of cholinergic mechanisms in central respiratory control is also given, along with the function of acetylcholine as an important transmitter at many sites of the central nervous system. The book concludes by analyzing the roles of cholinergic systems in motivated behaviors, emotion, learning, and memory. This book is a valuable resource for students and researchers in fields ranging from physiology to biology and psychiatry.
Author: Man Singh Publisher: Springer Science & Business Media ISBN: 1468412183 Category : Medical Languages : en Pages : 544
Book Description
Although serious interest in studying the role of central cho linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in volved in input selection, perception, cortical, autonomic and behav ioral activation, learning, memory, and inhibitory control of behav ioral outputs. To say that dysfunction of one or more of these mech anisms may be at the root of neuropsychiatric illnesses such as schiz ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.
Author: Alexander G. Karczmar Publisher: Springer Science & Business Media ISBN: 038746526X Category : Science Languages : en Pages : 698
Book Description
Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.
Author: Roger W. Russell Publisher: ISBN: Category : Languages : en Pages : 41
Book Description
It can be argued that the ultimate criterion for establishing a relation between the cholinergic system and a particular behavior pattern would be demonstration that arousal of or changes in the behavior occur following release of ACh, a criterion analogous to that for establishing the existence of chemical transmission at an interneuronal or a neuron-neuroeffector site. This criterion would require the collection of ACh and its quantitative assessment during the same period when the behavior was being measured, a technological feat beyond our present capabilities. It is necessary to fall back upon procedures which have provided indirect evidence for cholinergic transmission. These are pharmacological in nature, using drugs as 'tools' to alter the cholinergic system in some specified manner or to mimic the role of ACh. The operational definition of the phrase, 'relation between the cholinergic system and behavior, ' is in terms of concomitant variation between these two classes of variables. The paper begins by considering logical and methodological issues in the search for such relations: specification and measurement of neurochemical and behavioral variables; manipulation of variables; and localization in experimental variation of the neurochemical system. A discussion of examples from the research literature illustrates current trends in the search. (Author).
Author: Edward D. Levin Publisher: CRC Press ISBN: 1420004336 Category : Medical Languages : en Pages : 395
Book Description
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Author: Federico Bermudez-Rattoni Publisher: CRC Press ISBN: 1420008412 Category : Psychology Languages : en Pages : 368
Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author: David L. Clark Publisher: Cambridge University Press ISBN: 9780521840507 Category : Medical Languages : en Pages : 290
Book Description
New edition building on the success of previous one. Retains core aim of providing an accessible introduction to behavioral neuroanatomy.
Author: Jerry J. Buccafusco Publisher: CRC Press ISBN: 1420041819 Category : Medical Languages : en Pages : 341
Book Description
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Author: F DeFeudis
Author: F DeFeudis
Author: Man Singh
Author: Alexander G. Karczmar
Author: Roger W. Russell
Author: David M. Warburton
Author: Hans Christian Dringenberg
Author: Edward D. Levin
Author: Federico Bermudez-Rattoni
Author: David L. Clark
Author: Jerry J. Buccafusco