Author: John A T YoungPublisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
Book Description
Cellular Factors Involved in Early Steps of Retroviral Replication
Author: John A T YoungPublisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
Book Description
Cellular Factors Involved in Early Steps of Retroviral Replication
Author: John A.T. YoungPublisher: Springer Science & Business Media
ISBN: 364219012X
Category : Medical
Languages : en
Pages : 250
Book Description
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Host Cell Factors Involved in Retrovirus Replication and Disease Pathogenesis
Author: Shannon Beth SeidelPublisher:
ISBN: 9781267470218
Category :
Languages : en
Pages : 143
Book Description
Retroviruses are relevant human pathogens affecting the lives of tens of millions of people globally each year and resulting in nearly 2 million deaths annually. Understanding the process of retrovirus infection has wide benefits including the identification of therapeutic targets to treat HIV/AIDS and better understanding of cellular pathways disrupted in diseases, such as cancer and AIDS. Here, I first present my role in a collaborative project that led to the identification of over 200 cellular factors with potentially important roles in the early stages of retrovirus infection. We identified these factors through a genome-wide siRNA screen and through characterization of interactions between host and virus proteins. Additionally, I present my work on ZASC1, a host cell transcription factor that binds to the promoter regions of both HIV-1 and MLV and regulates virus gene expression in cultured established cell lines. I generated a ZASC1 knockout mouse model, showing that this gene is non-essential to development and reproduction. This mouse model was used to characterize the role of ZASC1 in retrovirus replication and disease pathogenesis. I showed that ZASC1 influences myeloid cell differentiation in this compartment and that this transcription factor is required for efficient early Mo-MuLV infection in the bone marrow compartment. Through studies of Mo-MuLV pathogenesis in the ZASC1 knockout mouse model, I show that despite this early defect, tumorigenesis is not regulated by ZASC1.
Human Retroviruses
Author: Bryan CullenPublisher: Oxford University Press
ISBN: 9780199633821
Category : Gene Expression Regulation.
Languages : en
Pages : 220
Book Description
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Encyclopedia of AIDS
Author: Thomas J. HopePublisher:
ISBN: 9781461496106
Category : AIDS (Disease)
Languages : en
Pages :
Book Description
HIV-1 Integrase
Author: Nouri NeamatiPublisher: John Wiley & Sons
ISBN: 1118015363
Category : Science
Languages : en
Pages : 710
Book Description
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Foamy Viruses
Author: Axel RethwilmPublisher: Springer Science & Business Media
ISBN: 9783540443889
Category : Medical
Languages : en
Pages : 232
Book Description
The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.
The Role of Cellular Factors in Retrovirus Replication
Author: Clarissa A. DirksContribution of Host Cell Factors to Early Events in Retroviral Replication
Author: James Gregory Greger (Jr)Publisher:
ISBN:
Category :
Languages : en
Pages : 194
Book Description
The Yeast Two-hybrid System
Author: Paul L. BartelPublisher: Oxford University Press, USA
ISBN: 9780195109382
Category : Carrier proteins
Languages : en
Pages : 362
Book Description
This volume, part of the Advances in Molecular Biology series, presents work by pioneers in the field and is the first publication devoted solely to the yeast two-hybrid system. It includes detailed protocols, practical advice on troubleshooting, and suggestions for future development. In addition, it illustrates how to construct an activation domain hybrid library, how to identify mutations that disrupt an interaction, and how to use the system in mammalian cells. Many of the contributors have developed new applications and variations of the technique.