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Author: Symposium on Ocular and Visual Development Publisher: Springer-Verlag ISBN: 3662265575 Category : Science Languages : de Pages : 205
Book Description
The eye has fascinated scientists from the earliest days of biological investigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes. but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development. a series of symposia on ocular and visual development was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical community. It is our feeling that much can be learned on both sides from this interaction. The idea for an informal meeting allowing maximum exchange of ideas originated with Dr. Leon Canbeub. who supplied the necessary driving force that made the series a reality. Each symposium has concentrated on a different aspect of ocular development. Speakers have been selected to approach related topics from different perspectives.
Author: Symposium on Ocular and Visual Development Publisher: Springer-Verlag ISBN: 3662265575 Category : Science Languages : de Pages : 205
Book Description
The eye has fascinated scientists from the earliest days of biological investigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes. but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development. a series of symposia on ocular and visual development was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical community. It is our feeling that much can be learned on both sides from this interaction. The idea for an informal meeting allowing maximum exchange of ideas originated with Dr. Leon Canbeub. who supplied the necessary driving force that made the series a reality. Each symposium has concentrated on a different aspect of ocular development. Speakers have been selected to approach related topics from different perspectives.
Author: J. B. Sheffield Publisher: Springer Science & Business Media ISBN: 1461257646 Category : Science Languages : en Pages : 205
Book Description
The eye has fascinated scientists from the earliest days of biological investigation. The diversity of its parts and the precision of their interac tion make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes. but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development. a series of symposia on ocular and visual development was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical community. It is our feeling that much can be learned on both sides from this interaction. The idea for an informal meeting allowing maximum exchange of ideas originated with Dr. Leon Canbeub. who supplied the necessary driving force that made the series a reality. Each symposium has concentrated on a different aspect of ocular development. Speakers have been selected to approach related topics from different perspec tives.
Author: Michael Bate Publisher: ISBN: 9780879698997 Category : Science Languages : en Pages : 0
Book Description
The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Author: Hubert Vaudry Publisher: Springer Science & Business Media ISBN: 9781402073069 Category : Medical Languages : en Pages : 432
Book Description
Pituitary Adenylate Cyclase-Activating Polypeptide is the first volume to be written on the neuropeptide PACAP. It covers all domains of PACAP from molecular and cellular aspects to physiological activities and promises for new therapeutic strategies. Pituitary Adenylate Cyclase-Activating Polypeptide is the twentieth volume published in the Endocrine Updates book series under the Series Editorship of Shlomo Melmed, MD.
Author: Kevin Moses Publisher: Springer Science & Business Media ISBN: 9783540425908 Category : Medical Languages : en Pages : 296
Book Description
1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Author: Evelyne Sernagor Publisher: Cambridge University Press ISBN: 1139459732 Category : Medical Languages : en Pages : 369
Book Description
This advanced text, first published in 2006, takes a developmental approach to the presentation of our understanding of how vertebrates construct a retina. Written by experts in the field, each of the seventeen chapters covers a specific step in the process, focusing on the underlying molecular, cellular, and physiological mechanisms. There is also a special section on emerging technologies, including genomics, zebrafish genetics, and stem cell biology that are starting to yield important insights into retinal development. Primarily aimed at professionals, both biologists and clinicians working with the retina, this book provides a concise view of vertebrate retinal development. Since the retina is 'an approachable part of the brain', this book will also be attractive to all neuroscientists interested in development, as processes required to build this exquisitely organized system are ultimately relevant to all other parts of the central nervous system.
Author: S. Robert Hilfer Publisher: Springer Science & Business Media ISBN: 1461239206 Category : Science Languages : en Pages : 185
Book Description
The eye has fascinated scientists from the earliest days of biological in vestigation. The diversity of its parts and the precision of their interaction make it a favorite model system for a variety of developmental studies. The eye is a particularly valuable experimental system not only because its tissues provide examples of fundamental processes, but also because it is a prominent and easily accessible structure at very early embryonic ages. In order to provide an open forum for investigators working on all aspects of ocular development, a series of symposia on ocular and visual devel opment was initiated in 1973. A major objective of the symposia has been to foster communication between the basic research worker and the clinical community. It is our feeling that much can be learned on both sides from this interaction. The idea for an informal meeting allowing maximum ex change of ideas originated with Dr. Leon Candeub, who supplied the nec essary driving force that made the series a reality. Each symposium has concentrated on a different aspect of ocular development. Speakers have been selected to approach related topics from different perspectives.
Author: S.R. Hilfer Publisher: Springer Science & Business Media ISBN: 1461252369 Category : Science Languages : en Pages : 191
Book Description
The Seventh Symposium on Ocular and Visual Development was held in October, 1982. The aim of the meeting was to develop a broad perspective on visual acuity. The subject was discussed initially in terms of molecular events of photoreception, and the metabolism of the photoreceptor ele ments. Subsequent papers presented the development and complexity of the neurocircuitry and transmitter systems in the retina that process the visual information prior to transfer to the brain. The meeting concluded with a series of papers on behavioral and physiological methods of mea surement of visual acuity in humans, particularly young children. This volume arose from the papers presented at the meeting. We feel that the juxtaposition of research of broadly differing methodologies will be stim ulating, rather than daunting, and will generate an enhanced understand ing of this complex subject. We are indebted to our colleagues: Dr. M. Mote from Temple University, and Drs. J. Siegfried, P. Dayhaw-Barker, and L. Press from the Pennsylvania College of Optometry for their expertise and assistance in the organization of the meeting; to the speakers for their presentations and contributions to this volume; and to the reviewers of the manuscripts for their helpful comments. This symposium could not have been held without the generous support of the Temple University College of Arts and Sciences and the Pennsyl vania College of Optometry. We also thank Merck, Sharp and Dohme, Inc. for their donation.
Author: Simón Carlos Publisher: ISBN: 9783036511528 Category : Languages : en Pages : 176
Book Description
Dear Colleagues, The science of human genetics has advanced at an exponential pace since the double-helix structure of DNA was identified in 1953. Within only 25 years of that discovery, the first gene was sequenced. Subsequent efforts in the span of a few decades have brought advanced next-generation sequencing and new tools for genome editing, allowing scientists to write and rewrite the code of life. We are now realizing that genetics represents yet another system of information technology that follows Moore's law, stating that computer processing power roughly doubles every two years. Importantly, with such rapid and sophisticated advancements, any tools or studies applicable to adult genetics can now also be applied to embryos. Genetic disorders affect 1% of live births and are responsible for 20% of pediatric hospitalizations and 20% of infant mortality. Many disorders are caused by recessive or X-linked genetic mutations carried by 85% of humans. Because assisted reproduction has armed us with technologies like in vitro fertilization that provide access to human embryos, we began to screen some genetic diseases simply by selecting sex. The first live births following preimplantation genetic testing (PGT) to identify sex in X-linked disease were reported by Alan Handyside in 1990. This groundbreaking work used the identification of male embryos and selective transfer of unaffected normal or carrier females as proof-of-concept to avoid genetic diseases, paving the way to extend the concept to PGT for monogenic diseases (PGT-M), including Mendelian single-gene defects (autosomal dominant/recessive, X-linked dominant/recessive), severe childhood lethality or early-onset disease, cancer predisposition, and HLA typing for histocompatible cord-blood stem cells' transplantation. Later, we moved onto the identification and selection of euploid embryos by analysing all 23 pairs of chromosomes in 4-8 cells from the trophectoderm, called PGT for aneuploidy (PGT-A). PGT-A currently leverages next-generation sequencing technologies to uncover meiotic- and mitotic-origin aneuploidies affecting whole chromosomes, as well as duplications/deletions of small chromosome regions. A step forward was the use of structural chromosome rearrangements (PGT-SR) to identify Robertsonian and reciprocal translocations, inversions, and balanced vs. unbalanced rearrangements. Another advancement came with PGT for polygenic risk scoring (PGT-P). This technique takes us from learning how to read simple words to starting to understand poetry (i.e., evolving from PGT-M/A/SR to PGT-P for multifactorial, polygenic risk prediction). Common multifactorial diseases like diabetes, coronary heart disease, and cancer are caused by a combination of environmental, lifestyle, and genetic factors; risk scores are now being generated to predict the likelihood of such complex, later-life diseases in embryos. Moreover, we are moving from embryo selection to intervention because the genetic code is not only readable, but also re-writeable. Indeed, gene editing is now possible using tools like CRISPR/Cas9, which are applicable to all species, including human embryos. In this Special Issue, we invite reviews, primers, and original research papers that contribute to our understanding of human embryo genetics. Specifically, we would like to compile the current knowledge in PGT for monogenic diseases (PGT-M), PGT for aneuploidy (PGT-A) including mosaicism, PGT for polygenic risk scoring (PGT-P), and gene editing in human embryos. Manuscripts can target both basic science as well as the clinical impact of embryogenetics in reproductive medicine, maternal-fetal medicine, and pediatrics. We look forward to your submissions
Author: Symposium on Ocular and Visual Development
Author: Symposium on Ocular and Visual Development
Author: J. B. Sheffield
Author: Helga Kolb
Author: Michael Bate
Author: Hubert Vaudry
Author: Kevin Moses
Author: Evelyne Sernagor
Author: S. Robert Hilfer
Author: S.R. Hilfer
Author: Simón Carlos