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Author: Elizabeth H. Chen Publisher: Methods in Molecular Biology ISBN: Category : Medical Languages : en Pages : 454
Book Description
In this book a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion. They further provide methods that present classic and state-of-the-art experimental approaches in a variety of systems.
Author: Elizabeth H. Chen Publisher: Methods in Molecular Biology ISBN: Category : Medical Languages : en Pages : 454
Book Description
In this book a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion. They further provide methods that present classic and state-of-the-art experimental approaches in a variety of systems.
Author: Henry Harris Publisher: ISBN: 9780674104648 Category : Cell differentiation Languages : en Pages : 108
Book Description
In this review of his and others' research in the field, Dr. Henry Harris, a pioneer in this work, provides and account of the development of the technique of fusing cells and describes the applications this technique has found in cell biology.
Author: David Evered Publisher: John Wiley & Sons ISBN: 0470718544 Category : Science Languages : en Pages : 192
Book Description
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author: Thomas Dittmar Publisher: Springer Science & Business Media ISBN: 9400707630 Category : Medical Languages : en Pages : 193
Book Description
Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.
Author: A.E. Sowers Publisher: Springer Science & Business Media ISBN: 147579598X Category : Science Languages : en Pages : 545
Book Description
Over the last decade the volume Membrane Fusion. edited by Poste and Nicholson, has probably served as one of the major sources of review in formation on fusion in membrane systems. Since its publication much new information has been collected. New methods of inducing fusion have been invented or discovered, and new applications for fusion have been found. The need for an up-to-date monograph that covers and in tegrates these subjects, reviews established material, and rationalizes and integrates the old and the new is thus obvious. This book is the product of efforts to meet this need. Most of the current work in the field of membrane fusion takes place within the context of intact or modified cells. Hence this book emphasizes the plasma membrane. Each chapter is either a review, a report, or a short historical overview, depending, respectively, on whether the subject is large in scope and has a long history, or the subject is in such an early stage of development that most of what is known is still in the hands of a relatively small number of investigators and is best covered in report form.
Author: Jose Cibelli Publisher: Academic Press ISBN: 0123865425 Category : Science Languages : en Pages : 585
Book Description
Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species—including mice, sheep, cattle, and non-mammals—is considered as well. The Editors have been involved in a number of breakthroughs using cloning technique, including the first demonstration that cloning works in differentiated cells done by the Recipient of the 2012 Nobel Prize for Physiology or Medicine – Dr John Gurdon; the cloning of the first mammal from a somatic cell – Drs Keith Campbell and Ian Wilmut; the demonstration that cloning can reset the biological clock - Drs Michael West and Robert Lanza; the demonstration that a terminally differentiated cell can give rise to a whole new individual – Dr Rudolf Jaenisch and the cloning of the first transgenic bovine from a differentiated cell – Dr Jose Cibelli. The majority of the contributing authors are the principal investigators on each of the animal species cloned to date and are expertly qualified to present the state-of-the-art information in their respective areas. - First and most comprehensive book on animal cloning, 100% revised - Describes an in-depth analysis of current limitations of the technology and research areas to explore - Offers cloning applications on basic biology, agriculture, biotechnology, and medicine
Author: Hitoshi Sawada Publisher: Springer ISBN: 4431545891 Category : Science Languages : en Pages : 463
Book Description
This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews recent progress in almost all fields of plant and animal fertilization. It was recently reported that the self-sterile mechanism of a hermaphroditic marine invertebrate (ascidian) is very similar to the self-incompatibility system in flowering plants. It was also found that a male factor expressed in the sperm cells of flowering plants is involved in gamete fusion not only of plants but also of animals and parasites. These discoveries have led to the consideration that the core mechanisms or factors involved in sexual reproduction may be shared by animals, plants and unicellular organisms. This valuable book is highly useful for reproductive biologists as well as for biological scientists outside this field in understanding the current progress of reproductive biology.
Author: National Research Council Publisher: National Academies Press ISBN: 0309173051 Category : Medical Languages : en Pages : 74
Book Description
The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.
Author: Stefan R. Schmidt Publisher: John Wiley & Sons ISBN: 1118354583 Category : Medical Languages : en Pages : 995
Book Description
The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.
Author: Elizabeth H. Chen
Author: Elizabeth H. Chen
Author: 
Author: Henry Harris
Author: David Evered
Author: Thomas Dittmar
Author: A.E. Sowers
Author: Jose Cibelli
Author: Hitoshi Sawada
Author: National Research Council
Author: Stefan R. Schmidt