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Author: Tong H. Joh Publisher: ISBN: Category : Medical Languages : en Pages : 188
Book Description
The study of the genomic regulation of catecholamine-related enzymes is a new field, emerging from the rapid advances in molecular neurobiology. This text offers detailed summaries of recent progress from the work of leading researchers in molecular genetics and enzymes. It concentrates primarily on the rate- limiting enzyme tyrosine hydroxylase, with several chapters devoted to its complex chemistry, plus an evolutionary view of its structural similarity to certain aromatic amino acid hydroxylases. The book covers the remaining three pathway enzymes and all other enzymes related to catecholamine genes.
Author: Tong H. Joh Publisher: ISBN: Category : Medical Languages : en Pages : 188
Book Description
The study of the genomic regulation of catecholamine-related enzymes is a new field, emerging from the rapid advances in molecular neurobiology. This text offers detailed summaries of recent progress from the work of leading researchers in molecular genetics and enzymes. It concentrates primarily on the rate- limiting enzyme tyrosine hydroxylase, with several chapters devoted to its complex chemistry, plus an evolutionary view of its structural similarity to certain aromatic amino acid hydroxylases. The book covers the remaining three pathway enzymes and all other enzymes related to catecholamine genes.
Author: Heinz Rupp Publisher: Springer Science & Business Media ISBN: 1461543517 Category : Science Languages : en Pages : 227
Book Description
The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System' in health and disease. In recent years, great progress has been made in the understanding of catecholamine and angiotensin II modulated gene expression. There is also increasing evidence that catecholamine and angiotensin II induced cellular injury not solely arises from classical pathways but also from a perturbed gene expression. Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure. An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focussed issue triggers novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.
Author: Toshiharu Nagatsu Publisher: Springer Science & Business Media ISBN: 1475735383 Category : Medical Languages : en Pages : 577
Book Description
This book is based on invited presentations at the Ninth International Catecholamine Symposiwn. Over several decades, each International Catecholamine Symposiwn (ICS) has provided a uniquely important forwn for updating basic as well as clinical research on the catecholamines, dopamine, norepinephrine, and epinephrine. The first ICS took nd n1 place in Bethesda, Maryland, in the USA in 1958; the 2 in Milan, Italy in 1965; the 3 th in Strasbourg, France in 1973; the 4th in Asilomar, California, USA in 1978; the 5 in th th Goteborg, Sweden in 1983; the 6 in Jerusalem, Israel,in 1987; the 7 in Amsterdam, th Netherlands in 1992; and the 8 in Asilomar, California, USA in 1996. th The 9 International Catecholamine Symposiwn (9ICS) was held in Kyoto, Japan, th March 31-April 5, 2001. This ICS was held concurrently with the 5 International th Conference on Progress in Alzheimer's and Parkinson's Disease (5 ADPD). These international meetings were coordinated to be a joint international congress. Catecholamines and related neurotransmitters and neuromediators play important roles in the pathogenesis of symptoms and neurodegenerative processes of Alzheimer's disease and Parkinson's disease. Therefore, the Joint Congress provided an opportunity for investigators and clinicians working in these fields to exchange their· most recent investigational results and clinical experiences. This Joint International Congress turned out to be an enormous success, attended by 1258 participants from 38 countries, in an enthusiastic and pleasant atmosphere.
Author: Toshiharu Nagatsu Publisher: Springer Science & Business Media ISBN: 3709191467 Category : Medical Languages : en Pages : 297
Book Description
This b00k reviews the recent advances in the research on Parkinson's disease. It contains review articles from basic to clinical researches including the historical introduction and the molecular biological approach to Parkinson's disease. Parkinson's disease is the most representative, age-related neurodegenerative disease. It is clinically characterized by movement disorders such as muscle rigidity, akinesia and tremor. The elucidation of its biochemical and molecular mechanisms has rapidly been progressing and is expected to contribute to the understanding of normal brain aging in general. This project is supported by a Grant-in-Aid for Scientific Research on Priority Areas, "Molecular Biology of the Motor System", Ministry of Education, Science and Culture, Japan, for 3 years from 1987 to 1989. We are grateful for the support. These reviews are a part of the works which have been supported by this Grant-in-Aid. The characteristics of this research project on Parkinson's disease are interdisciplinary approach from basic, molecular biology to clinical medicine, and the molecular biological approach is expected to be the most promising for the elucidation of the pathogenesis. The collaboration and discussion between basic and clinical researchers in this Priority Area Project has been efficient and productive. We hope that this book can mark another new milestone in the studies on Park,oson's disease and in neuroscience. We are very grateful to Nippon Schering for their generous support for the publication of this book. Last but not least, we thank Springer-Verlag Wien New York for the excellent production of this book and the excellent cooperation.
Author: Lee E. Eiden Publisher: Academic Press ISBN: 012411539X Category : Medical Languages : en Pages : 500
Book Description
This new volume of Advances in Pharmacology presents catecholamine symposium proceedings. Chapters cover such topics as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Presents catecholamine symposium proceedings - Chapters cover a variety of topics such as cellular dynamics of catecholamine release and re-uptake, catecholamines in mood regulation and imaging catecholamine transporters - With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike
Author: Heinz Rupp Publisher: Springer Science & Business Media ISBN: 9780792379812 Category : Medical Languages : en Pages : 252
Book Description
The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System' in health and disease. In recent years, great progress has been made in the understanding of catecholamine and angiotensin II modulated gene expression. There is also increasing evidence that catecholamine and angiotensin II induced cellular injury not solely arises from classical pathways but also from a perturbed gene expression. Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure. An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focussed issue triggers novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.
Author: Tong H. Joh
Author: Tong H. Joh
Author: Heinz Rupp
Author: Toshiharu Nagatsu
Author: Toshiharu Nagatsu
Author: Lee E. Eiden
Author: Richard Palmiter
Author: Chung-Hyung Kim
Author: Daniel O’Connor
Author: B.L. Roth
Author: Heinz Rupp