Carnitine Today PDF Download

Author: Giuseppe Famularo
Publisher: Springer Science & Business Media
ISBN: 1461560055
Category : Medical
Languages : en
Pages : 275

View

Book Description

Author: Salvatore Alesci
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 224

View

Book Description
Carnitine is a naturally occurring compound with a central role in intermediate metabolism. This nutrient is widely used as a dietary supplement for its actions on fat metabolism, muscle performance, and cognitive function. Several commercials promote its use by athletes and to combat obesity and aging without dose- or side-effect specifications, an issue of obvious public health relevance. Approved medical indications for carnitine supplementation include primary (systemic or myopathic) carnitine deficiencies and secondary depletion states observed in organic acidemias, beta-oxidation, and respiratory chain defects and in chronic renal and heart failure. Recent basic and clinical research supports a variety of beneficial effects of carnitine on the cardiovascular, immune, and nervous systems, on insulin resistance and obesity, apoptosis, and cancer. disease; in the lipodystrophy and neuropathy of HIV patients; in cancer-cachexia; in neurodegenerative disorders and the chronic fatigue syndrome; and in fertility, pregnancy, and premature neonates all show a wide range of potential applications for this natural nutrient, but have often led to contradictory results and

Author: Claude Desnuelle
Publisher: Springer Science & Business Media
ISBN: 2817809297
Category : Medical
Languages : en
Pages : 314

View

Book Description
The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies." In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with clinically diverse disorders has left practitioners puzzled about diagnosing such heterogeneous and complex syndromes. Through updated data, this book discusses now what Luft aptly called "mitochondrial medicine." In so doing, it considers the pivotal role of mitochondria in drug sensitivity, their key roles in ageing, apoptosis, and neurodegeneration along with primary mitochondrial diseases due to mutations in the nuclear genome, in the mitochondrial genome, or in the cross-talk between the two genomes.

Author: Vincenzo Zappia
Publisher: Springer Science & Business Media
ISBN: 1475732309
Category : Medical
Languages : en
Pages : 313

View

Book Description
This volume includes contributions presented at the Second International Sym posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle.

Author: Paul M. Coates
Publisher: CRC Press
ISBN: 0824755049
Category : Health & Fitness
Languages : en
Pages : 842

View

Book Description
PRINT/ONLINE PRICING OPTIONS AVAILABLE UPON REQUEST AT [email protected]

Author:
Publisher: Academic Press
ISBN: 0080912257
Category : Science
Languages : en
Pages : 234

View

Book Description
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.

Author: Patti A. Quant
Publisher: Springer Science & Business Media
ISBN: 0306468182
Category : Science
Languages : en
Pages : 405

View

Book Description
Bringing together biochemical, genetic, molecular biology, and clinical approaches to the study of fatty acid oxidation, this text includes late-1990s research from most of the major groups working in this field. It provides a multi-disciplinary approach to the subject and an up-to-date overview of the most recent developments and debates.

Author: Paul M. Coates
Publisher: CRC Press
ISBN: 1498702252
Category : Health & Fitness
Languages : en
Pages : 918

View

Book Description
Encyclopedia of Dietary Supplements presents peer-reviewed, objective entries that rigorously examine the most significant scientific research on basic chemical, preclinical, and clinical data. Designed for healthcare professionals, researchers, and health-conscious consumers, it presents evidence-based information on the major vitamin and mineral micronutrients, herbs, botanicals, phytochemicals, and other bioactive preparations. Supplements covered include: Vitamins, beta-carotene, niacin, and folate Omega-3 and omega-6 fatty acids, isoflavones, and quercetin Calcium, copper, iron, and phosphorus 5-hydroxytryptophan, glutamine, and L-arginine St. John's Wort, ginkgo biloba, green tea, kava, and noni Androstenedione, DHEA, and melatonin Coenzyme Q10 and S-adenosylmethionine Shiitake, maitake, reishi, and cordiceps With nearly 100 entries contributed by renowned subject-specific experts, the book serves as a scientific checkpoint for the many OTC supplements carried in today's nutritional products marketplace. Also Available OnlineThis Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including: Citation tracking and alerts Active reference linking Saved searches and marked lists HTML and PDF format options Contact Taylor and Francis for more information or to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367; (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062; (E-mail) [email protected]

Author: Salah Abdel-aleem
Publisher: Springer Science & Business Media
ISBN: 1461556872
Category : Science
Languages : en
Pages : 192

View

Book Description
This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews focused in the field of cardiac metabolism and its regulation under normal and disease conditions. These papers cover many areas under intensive and rapid development such as the regulation of fatty acid oxidation in the heart, the role of cardiac glycogen during ischemia, the role of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac protection through regulation of energy production, the role of fatty acid binding protein under normal and pathological conditions, and several other important topics in this area of research. We hope that this special issue of Molecular and Cellular Biochemistry provides an up-to-date source of information for scientists and clinicians interested in the mechanism by which cardiac metabolism is regulated in health and disease and the mechanistic relationship between disturbances in cardiac metabolism and the genesis of cardiovascular diseases.

Author: Klaus Kramer
Publisher: CRC Press
ISBN: 0824741757
Category : Medical
Languages : en
Pages : 317

View

Book Description
Promoting scientific support for the plethora of health benefits related to nutrition and medicine, Nutraceuticals in Health and Disease Prevention delivers a comprehensive and scientifically sound overview of the latest research findings in disease prevention, therapy, and enhanced body function in the revolutionary field of nutraceutical technology-with highlights from the Nutraceutical Conference held in Ludwigshafen, Germany. Includes perspectives and reviews from recognized experts on nutraceuticals of scientific and public interest! Recognizing the need to control the balance between environmental stressors and human health, Nutraceuticals in Health and Disease Prevention presents developing areas of nutraceutical research with studies of effective examples examines pathology treatments, including effects of S-adenosylmethionine (SAMe) on inflammatory disease and polyphenols on cardiovascular disease investigates the role and benefits of vitamin E in aging and the antioxidant network discusses the potency, multiple uses, and metabolic aspects of lipoic (thioctic) acid reviews the second generation of carotenoid research and the disease prevention properties of lycopene and lutein considers how polyunsaturated fatty acids (PUFAs) contribute to a healthy diet, from clinical and molecular perspectives profiles the efficacy, safety, and use of creatine as an anabolic nutraceutical by athletes analyzes identification methods for optimum delivery of nutrients, illustrated by the example of methyltetrahydrofolate and much more! Containing over 1100 valuable literature references, drawings, and tables, Nutraceuticals in Health and Disease Prevention functions as an indispensable reference in the libraries of nutritionists and dietitians, pharmacists, molecular and cell biologists and biochemists, oncologists, endocrinologists, dermatologists, physiologists, epidemiologists, neurochemists, pediatricians, and upper-level undergraduate, graduate, and medical school students in these disciplines.