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Author: Yan Yang Publisher: Frontiers Media SA ISBN: 2832531687 Category : Medical Languages : en Pages : 227
Book Description
Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically. Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.
Author: Yan Yang Publisher: Frontiers Media SA ISBN: 2832531687 Category : Medical Languages : en Pages : 227
Book Description
Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically. Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.
Author: Giorgio Iervasi Publisher: Springer Nature ISBN: 3030368718 Category : Medical Languages : en Pages : 429
Book Description
In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.
Author: Dennis V. Cokkinos Publisher: Springer ISBN: 3319981862 Category : Medical Languages : en Pages : 406
Book Description
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.
Author: Monte Willis Publisher: Academic Press ISBN: 0124055257 Category : Medical Languages : en Pages : 339
Book Description
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Author: Gianfranco Sinagra Publisher: Springer ISBN: 303013864X Category : Medical Languages : en Pages : 239
Book Description
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Author: E. Gratacós Publisher: S. Karger AG (Switzerland) ISBN: 9783318022186 Category : Fetal heart Languages : en Pages : 0
Book Description
Fetal echocardiography was initially used to detect structural anomalies, but has more recently also been proposed to assess fetal cardiac function. Functional echocardiography has been demonstrated to select high-risk populations and has been seen to have an effect on the outcome of several fetal conditions. Because of the small size and high heart rate and the restricted access away from the transducer, cardiovascular parameters should be validated but used with caution in the fetus. This special issue on fetal cardiac function is a collection of review and original articles showing several potential clinical and research applications of functional echocardiography in intrauterine growth restriction, twin-to-twin transfusion syndrome, congenital heart disease and aneuploides. The insights provided show that fetal cardiac function assessment is a promising tool that may soon be incorporated into clinical practice to diagnose, monitor or predict outcome in some fetal conditions. Therefore, this special issue on 'fetal cardiac function' provides valuable reading for clinicians and researchers in fetal medicine and cardiology who are interested in the fetal heart.
Author: G. Michael Felker Publisher: Elsevier Health Sciences ISBN: 0323609880 Category : Medical Languages : en Pages : 937
Book Description
Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Author: Morris Karmazyn Publisher: Springer Science & Business Media ISBN: 9783764352691 Category : Medical Languages : en Pages : 538
Book Description
Myocardial ischemia and subsequent reperfusion of the ischemic myocardium represent complex phenomena encompassing numerous physiological processes. This book aims at enhancing our understanding of these processes and stresses recent important developments in this very active area of research. The concise, state-of-the-art reviews cover recent advances in many fields important to the area of myocardial ischemia and reperfusion including physiology, pathology, pharmacology, biochemistry and molecular biology with reference to clinical relevance and applicability of these findings. Major areas which are highlighted include vascular mechanisms resulting in myocardial ischemia, cellular events in the ischemic, postinfarcted and reperfused myocardium as well as new exciting developments in cardiac protection that involve both novel pharmacological approaches as well as endogenous cardioprotective mechanisms such as preconditioning. Aimed at both the basic and clinical cardiovascular investigator, the book comprehensively reviews the rapid progress made in recent years in understanding the etiology of myocardial ischemia and reperfusion. It will further serve as an authoritative reference for all those interested in learning about the important developments in the treatment of myocardial ischemic and reperfusion disorders.
Author: Yan Yang
Author: Yan Yang
Author: Giorgio Iervasi
Author: Lakshmi Santhanam
Author: Dennis V. Cokkinos
Author: Monte Willis
Author: Gianfranco Sinagra
Author: E. Gratacós
Author: Yunlong Huo
Author: G. Michael Felker
Author: Morris Karmazyn