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Author: J. Morganroth Publisher: Springer Science & Business Media ISBN: 1461325951 Category : Medical Languages : en Pages : 359
Book Description
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Author: J. Morganroth Publisher: Springer Science & Business Media ISBN: 1461325951 Category : Medical Languages : en Pages : 359
Book Description
In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .
Author: I. Eli Ovsyshcher, MD, PhD, FESC, FACC Publisher: Wiley-Blackwell ISBN: 9780879934552 Category : Medical Languages : en Pages : 423
Book Description
The final decades of this century have been a period of expansive growth for the electrophysiological management of cardiac arrhythmias. Subsequently, the rapid and widespread clinical application of so many technological advances has made the exchange of ideas in this field an urgent necessity. Cardiac Arrhythmias and Device Therapy: Results and Perspectives for the New Century addresses the issue by gathering current, relevant information in a clear, user-friendly format. This book covers a broad spectrum of subjects, including basic electrophysiology (impulse propagation, subthreshold stimulation, genetics and the molecular base of arrhythmias), invasive and noninvasive clinical electrophysiology, and the clinical aspects of cardiac pacing and defibrillation. It provides a comprehensive review of various methods of treatment of atrial fibrillation, and of the role of pacing in prevention of atrial fibrillation and in treatment of congestive heart failure, dilated, hypertrophic, and restrictive cardiomyopathies. The results of recent clinical trials in cardiac pacing and in the prevention and treatment of malignant venticular arrhythmias are also presented. Special sections have been dedicated to the various aspects of preventing sudden death, including the use of internal and external defibrillation. Finally, the book offers a current review of "hot" topics, with personal experiences and critical evaluations by the world-renowned authors. This book will be of interest to all cardiologists, EP technicians, and health care personnel involved in the diagnosis and management of arrhythmias, who wish to gain a complete perspective on modern pacing and electrophysiology.
Author: Raymond Woosley Publisher: CRC Press ISBN: 9780824781644 Category : Medical Languages : en Pages : 0
Book Description
This vitally important reference traces the progress of antiarrhythmic drug trials and treatment methods-from the vantage point of the clinicians who designed and conducted the studies to objective views of the strengths and weaknesses of the results, identifying unresolved questions or newly created issues. Reviews significant studies in chronological order-providing a clear, informative account of how current thinking about arrhythmia treatment has evolved. Written by over 35 leading experts in the field, Clinical Trials on the Treatment of Arrhythmias emphasizes the need for science-based therapeutics and rigorously controlled clinical trials of drugs and implantable devices compares electrocardiographic monitoring with electrophysiological techniques for arrhythmia management analyzes the landmark Cardiac Arrhythmia Suppression Trial (CAST) evaluates the effectiveness of amiodarone describes sodium and potassium channel blockers and the development of drugs that slow conduction velocity and prolong repolarization and refractoriness investigates the effects of the d-isomer of sotalol on mortality critiques studies on the established efficacy of implantable devices versus amiodarone to benefit post-bypass surgery patients and more! Containing over 600 literature citations, Clinical Trials on the Treatment of Arrhythmias is an invaluable resource for cardiologists and cardiovascular specialists, pharmacologists, pharmaceutical researchers, and graduate and medical school students in these disciplines.
Author: Ruey J. Sung Publisher: Springer Science & Business Media ISBN: 9401143714 Category : Medical Languages : en Pages : 826
Book Description
This new edition provides up-to-date comprehensive coverage of the rapidly evolving field of clinical cardiac electrophysiology. It is designed for physicians, cardiologists, cardiac electrophysiologists, and allied professionals practising or learning the speciality of clinical cardiac electrophysiology. This textbook - written entirely by two practising authorities in the field - offers a cohesive and comprehensive summary of the principles and practice of clinical cardiac electrophysiology. The authors emphasize the clinical approach to the patient and provide a fundamental, yet thorough, discussion of the primary therapeutic modalities used today in a state-of-the-art electrophysiology laboratory, including the latest pharmacotherapy options, catheter ablation treatment, and the newest implantable devices. The authors provide the reader with a concise, organized discussion of the management of patients with benign to life-threatening arrhythmias using the newest concepts, equipment, and techniques of diagnostic and therapeutic electrophysiology.
Author: Robert E. Kass Publisher: Springer Science & Business Media ISBN: 9783540249672 Category : Medical Languages : en Pages : 384
Book Description
This book incorporates the most up-to date information related to mechanisms and treatment of cardiac arrhythmia. Many of the topics discussed in this text reflect very recently undertaken research directions including genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These new approaches and implementations of anti-arrhythmic therapy derive from many decades of research as outlined in the first chapter by distinguished Professors Michael Rosen (Columbia University) and Michiel Janse (University of Amsterdam). The text covers changes in approaches to therapy over time, arrhythmias in multiple cardiac regions and over many scales, from gene to protein to cell to tissue to organ.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 030915698X Category : Medical Languages : en Pages : 304
Book Description
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author: John M. Miller Publisher: ISBN: 9781416062752 Category : Arrhythmia Languages : en Pages : 0
Book Description
Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.
Author: Euan A. Ashley Publisher: Remedica ISBN: 1901346226 Category : Cardiology Languages : en Pages : 258
Book Description
One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
Author: George J. Klein Publisher: McGraw-Hill Education / Medical ISBN: 9781260118209 Category : Medical Languages : en Pages : 592
Book Description
The acclaimed primer of electrophysiology – from two leading experts Cardiac Arrhythmias: Interpretation, Diagnosis and Treatment, Second Edition is a practical clinical guide for healthcare professionals who seek a basic knowledge of electrophysiology and how to interpret and treat patients with arrhythmias. One of the main benefits of this book is the author’s ability to take electrophysiology and break it down clearly and simply so internists and family practitioners who do not have an extensive background in this complex aspect of cardiology can understand it and its relationship to treating arrhythmias. The Second Edition has been updated to include the latest treatment advances, new and important clinical trials, additional cases, and coverage of new drugs and devices; and is enhanced by full-color tracings, and an increased number of tables and illustrations.
Author: J. Morganroth
Author: J. Morganroth
Author: I. Eli Ovsyshcher, MD, PhD, FESC, FACC
Author: Raymond Woosley
Author: Ruey J. Sung
Author: Robert E. Kass
Author: Institute of Medicine
Author: John M. Miller
Author: J. Morganroth
Author: Euan A. Ashley
Author: George J. Klein