Author: Tao TanPublisher:
ISBN: 9789403400464
Category :
Languages : en
Pages :
Book Description
Carbon-nitrogen Bond Formation Via Catalytic Alcohol Activation
Author: Tao TanCatalytic Methods for Carbon-carbon and Carbon-nitrogen Bond Formation
Author: Stephen David RamgrenPublisher:
ISBN:
Category :
Languages : en
Pages : 511
Book Description
This dissertation describes the study of metal-catalyzed cross-coupling reactions to construct carbon-carbon and carbon-heteroatom bonds. The key feature of much of this work is the use of inexpensive Ni and Fe catalysts to enable the coupling of unconventional electrophilic substrates, specifically aryl O-sulfamates and O-carbamates. The ability to use O-sulfamates and O-carbamates in catalytic processes is notable, as these substrates are readily derived from phenols and can be used for directed arene functionalization. Chapter one provides a summary of the efforts towards using alcohol-based solvents for the Suzuki-Miyaura cross-coupling reaction. Emphasis is placed on the cross-coupling of heterocycles, which are commonly encountered in natural product synthesis and in the pharmaceutical sector. Chapters two, three, and four describe carbon-nitrogen bond forming reactions. Chapter two pertains to the nickel-catalyzed amination of sulfamates, which culminated in the synthesis of the antibacterial drug, linezolid. Chapter three covers the amination of aryl O-carbamates and their use in sequential functionalization/site-selective cross-couplings. Chapter four describes a more user-friendly variant of the amination reaction, which relies on a bench-stable Ni(II) precatalyst, rather than a more commonly used Ni(0) precatalyst. Chapters five, six, and seven focus on carbon-carbon bond formation via Fe-, Ni- and Pd-mediated processes. Chapter five pertains to iron-catalyzed couplings of sulfamates and carbamates to generate sp2-sp3 carbon-carbon bonds. This method can be used to assemble sterically-congested frameworks. Chapter six describes the nickel-catalyzed Suzuki-Miyaura reactions of halides and phenol derivatives in `green' solvents, which was applied to the preparative scale assembly of bis(heterocycles) using low nickel catalyst loadings. Chapter seven pertains to the acetylation of arenes using palladium catalysis, which provides a simple and efficient means for the construction of a variety of aryl methyl ketones.
New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation
Author: Rui ShangPublisher: Springer
ISBN: 9811031932
Category : Science
Languages : en
Pages : 225
Book Description
This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation. The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner.
Homogenous Catalytic Formation of Carbon-Nitrogen Bonds. 2. Catalytic Activation of the Silicon-Ntirogen Bond
Author: M. T. ZoecklerAlkylation and C-N Bond Activation are Catalyzed by Alcohols
Author: Kishore SinnuPublisher: Self Employed
ISBN:
Category : Business & Economics
Languages : en
Pages : 0
Book Description
In the field of organic chemistry, the use of alcohols as catalysts for C-N bond activation and alkylation reactions has garnered significant attention in recent years. Jagannath Rana, a renowned chemist, has contributed greatly to this area of research through his groundbreaking studies. Alcohols, a widely available and environmentally friendly resource, have proven to be effective catalysts for a variety of chemical reactions, including C-N bond activation and alkylation. This type of catalysis can be achieved with either homogeneous or heterogeneous catalysis. Homogeneous catalysis, in which the alcohol is completely dissolved in the reaction mixture, is widely used in laboratory-scale reactions. Heterogeneous catalysis, on the other hand, involves the use of a solid-supported alcohol catalyst, which can be recycled and reused. The activation of C-N bonds using alcohols as catalysts is a highly efficient and selective process. The reaction occurs by nucleophilic attack of the amide or other nitrogen-containing compound on the activated alcohol. The resulting intermediate can undergo alkylation by a variety of electrophiles, including alkyl halides, alkenes, and alkynes. The use of alcohols as catalysts for C-N bond activation and alkylation reactions has several advantages over traditional methods. First, alcohols are abundant and inexpensive, making them an attractive alternative to more costly catalysts. Additionally, alcohols are non-toxic and can be used in environmentally friendly, sustainable chemistry practices. Rana's research has focused on the use of metal catalysis for C-N bond activation and alkylation reactions using alcohols as catalysts. In particular, he has studied the use of palladium catalysts in these reactions, as palladium is a widely available and inexpensive metal with excellent catalytic activity. Rana's work has demonstrated that palladium-catalyzed C-N bond activation and alkylation using alcohols as catalysts can be highly selective, producing the desired products with high yields and minimal waste. Overall, the use of alcohols as catalysts for C-N bond activation and alkylation reactions is a promising area of research in the field of organic chemistry. Rana's contributions have advanced our understanding of this process and opened up new avenues for the development of sustainable, environmentally friendly chemical processes.
Gold and Silver Catalysis of Carbon-Nitrogen Bond Formation and Cycloaddition Reactions
Author: David Anthony CaprettoPublisher:
ISBN: 9781124717418
Category :
Languages : en
Pages : 131
Book Description
This dissertation describes four research topics all based on the catalytic reactivity of silver and gold complexes. Chapter I details work towards the development of a silver catalyzed nitrene transfer reaction with high activity for benzylic and even alkyl C-H bonds. Chapter II describes the development of a gold(III) catalyzed aryl C-N bond formation. Chapter III describes the synthesis and exploitation of a new diaziridine molecule for use in gold(I) catalyzed cycloaddition chemistry with terminal alkynes. Chapter IV describes efforts toward the natural product synthesis of oligomers based on the resveratrol molecule.
Hydrogen Transfer Reactions
Author: Gabriela GuillenaPublisher: Springer
ISBN: 3319430513
Category : Science
Languages : en
Pages : 393
Book Description
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Developments and Applications of Methods for Palladium- and Copper-catalyzed Carbon-nitrogen Bond Formation
Author: Jeffrey Chih-Yeh YangPublisher:
ISBN:
Category :
Languages : en
Pages : 467
Book Description
The studies presented in this dissertation are aimed at the development and application of methodologies that enable carbon-nitrogen (C-N) bond formation catalyzed by late transition metals such as palladium and copper. The first part of this thesis focuses on the use of palladium catalysis for the construction of a carbon(sp2)-nitrogen bond in the context of a biphasic continuous-flow system (Chapter 1). The second part of this thesis describes the recent developments of copper-hydride (CuH) catalyzed asymmetric hydroamination for the formation of a-chiral carbon(sp3)-nitrogen bonds from olefins. This work includes the application of CuH catalysis to the synthesis of chiral N-alkyl aziridines (Chapter 2), and the discovery and development of novel electrophilic amines to enable CuH-catalyzed asymmetric hydroamination to directly access primary amines (Chapter 3). Part I. Chapter 1. Use of a "Catalytic" Cosolvent, N,N-Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch A general, efficient method for C-N cross-coupling has been developed using N,N-dimethyloctanamide as a cosolvent for biphasic continuous-flow applications. In addition to utilizing a proper co-solvent, the described method harnesses the superior mixing abilities of a stainless-steel powder packed tube reactor to efficiently couple a wide range of aryl/heteroaryl halides and aryl/heteroaryl/alkyl amines in a short period of time (
C-C Bond Activation
Author: Guangbin DongPublisher: Springer
ISBN: 364255055X
Category : Science
Languages : en
Pages : 265
Book Description
The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students
New and Future Developments in Catalysis
Author: An-Hua LiuPublisher: Elsevier Inc. Chapters
ISBN: 0128082232
Category : Science
Languages : en
Pages : 113
Book Description