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Author: Binghe Wang Publisher: John Wiley & Sons ISBN: 9781119783435 Category : Medical Languages : en Pages : 0
Book Description
"Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent. We have divided the book into four sections that provide a framework for the reader to follow the evolution of CO from an accepted poison to a bioactive molecule that may offer enormous clinical benefits"--
Author: Binghe Wang Publisher: John Wiley & Sons ISBN: 9781119783435 Category : Medical Languages : en Pages : 0
Book Description
"Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent. We have divided the book into four sections that provide a framework for the reader to follow the evolution of CO from an accepted poison to a bioactive molecule that may offer enormous clinical benefits"--
Author: Binghe Wang Publisher: John Wiley & Sons ISBN: 1119783402 Category : Science Languages : en Pages : 556
Book Description
CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.
Author: Surinder K. Mehta Publisher: John Wiley & Sons ISBN: 3527348689 Category : Science Languages : en Pages : 292
Book Description
Metallosurfactants Provides up-to-date coverage of the synthesis, properties, and applications of metallosurfactants Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is a thorough introduction to amphiphilic compounds that allow to incorporate metal ions in the surfactant system. This comprehensive reference and guide describes the fundamentals of metal surfactant complexes, highlights recent advances in the field, and explores current and future applications and research areas. Gradually progressing from basic to advanced topics, the authors first explain the classification and characterization of metallosurfactants before delving into more complex concepts and various catalytic, sensing, and biomedical applications. The book begins with coverage of the synthesis of metallosurfactants and their surface, interfacial, and aggregation behavior. Subsequent chapters discuss applications of metallosurfactants in areas such as drug delivery, molecular machines, transfection, nanoparticle synthesis, and carbon monoxide-releasing molecules (CORMs). Other topics include the use of metallosurfactants as catalysts in organic reactions, and as anticancer and antimicrobial agents in drug delivery and formulation. This unique reference Provides an overview of the structure-function relationship, synthesis methods, and characterization of metallosurfactants Reviews current trends in metallosurfactant development and research Examines the use of metallosurfactants in a wide range of reactions, including esterolytic reactions and hydrogen generation Discusses advanced applications of metallosurfactants, e.g. as nanoreactors for nanoparticle synthesis, non-viral transfection vectors, and sensors Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is an excellent introduction to the growing field of metallosurfactant chemistry as well as a concise, highly useful reference for researchers and scientists in both academia and industry.
Author: Michael Decker Publisher: Elsevier ISBN: 0081011180 Category : Science Languages : en Pages : 354
Book Description
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. - Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes - Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied - Compares the advantages and disadvantages of these compounds - Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Binghe Wang Publisher: John Wiley & Sons ISBN: 1118833368 Category : Science Languages : en Pages : 740
Book Description
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Author: Jean-Paul Renaud Publisher: John Wiley & Sons ISBN: 1118900502 Category : Medical Languages : en Pages : 1437
Book Description
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Author: T. W. Stone Publisher: Oxford University Press, USA ISBN: 9780198609421 Category : Medical Languages : en Pages : 476
Book Description
About half of all the medicines prescribed by doctors are not taken by their patients. One of the reasons most commonly given by patients for not taking drugs is that they feel unhappy about taking medicines which they do not understand and of which they are afraid. This book attempts to rectify this problem by showing in clear, non-technical language how medicines and other drugs work in the body to reduce the effects of disease. Most chapters include fascinating background information on how some of our most important drugs were discovered, along with intriguing and often amusing anecdotes about the drugs and the people behind their discovery. Each chapter also includes a summary of the key points together with illustrations, photographs or diagrams to summarise the main groups and how they work in the body. The book covers all the major groups of drugs, with complete listings of all the drugs available in the UK and the USA, so that the reader can locate his or her specific drug and read about the actions of the drugs in that group. The various chapters cover drugs used to treat high blood pressure, heart disease, diabetes, nausea, vomiting, diarrhoea, constipation, ulcers, cancers, infections, impotence, incontinence, arthritis, osteoporosis, as well as hormone replacement therapy, oral contraceptives and drugs used in disorders of the brain such as schizophrenia, depression, Parkinson's disease, Alzheimer's disease and epilepsy. There is also a chapter on drugs which are abused such as cannabis, alcohol, nicotine and ecstasy, and a chapter covering some of the poisons we encounter, such as carbon monoxide, arsenic, sheep dip, and the venoms of snakes, spiders, scorpions and marine organisms. Here, then, a fascinating survey of how chemicals have their effects in the body. It shows how drugs work and explains why it is that taking some medicines for many years is far safer than suffering the long-term effects of disease. Pills, Potions and Poisons is an entertaining read that should also help to improve your health and quality of life.
Author: National Research Council Publisher: National Academies Press ISBN: 030915233X Category : Nature Languages : en Pages : 465
Book Description
This book is the eighth volume in the series Acute Exposure Guideline Levels for Selected Airborne Chemicals, and reviews AEGLs for acrolein, carbon monoxide, 1,2-dichloroethene, ethylenimine, fluorine, hydrazine, peracetic acid, propylenimine, and sulfur dioxide for scientific accuracy, completeness, and consistency with the NRC guideline reports.
Author: Binghe Wang
Author: Binghe Wang
Author: Binghe Wang
Author: Surinder K. Mehta
Author: Michael Decker
Author: Raymond Hill
Author: United States. Public Health Service. Office of the Surgeon General
Author: Binghe Wang
Author: Jean-Paul Renaud
Author: T. W. Stone
Author: National Research Council