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Author: David M. Langenau Publisher: Springer ISBN: 9783319306520 Category : Medical Languages : en Pages : 0
Book Description
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Author: David M. Langenau Publisher: Springer ISBN: 9783319306520 Category : Medical Languages : en Pages : 0
Book Description
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Author: David M. Langenau Publisher: Springer ISBN: 3319306545 Category : Medical Languages : en Pages : 552
Book Description
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Author: Samuel Cartner Publisher: Academic Press ISBN: 0128124326 Category : Science Languages : en Pages : 720
Book Description
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Author: Kathleen Lindahl Pfaff Publisher: ISBN: 9781109838176 Category : Zebra danio Languages : en Pages : 222
Book Description
Using HeLa cells, we found that the requirement for SIL in mitotic spindle organization is conserved in mammalian cells. A polyclonal antibody revealed endogenous SIL localizes to the mitotic spindle poles during metaphase. Similar to the defects in the csp mutant zebrafish, two short hairpin RNAs targeted against SIL caused microtubule disorganization in HeLa cells. The combination of results from the zebrafish and mammalian studies show that SIL is required for proper organization of the mitotic spindle.
Author: FableVision Publisher: Simon and Schuster ISBN: 1442406097 Category : Juvenile Fiction Languages : en Pages : 128
Book Description
Vita is a purple-haired singing queen, and she has big dreams for her rock group, Zebrafish. But when she holds auditions for the back-up band, tryouts are sorely lacking in the musical ability department. Luckily her new bandmates—Walt, Tanya, Jay, and Plinko—have other talents. But lately Tanya has been missing a lot of rehearsals. When Vita discovers why, she realizes that the group can be about much more than one person, one band, or even one school. A concert won’t cure Tanya’s cancer or make her treatments any less painful, but, in their own way, Zebrafish can make a difference—and the tale of their unlikely success is sure to strike a chord with young readers looking to make their world a better place.
Author: Prasan R. Bhandari Publisher: Springer Nature ISBN: 9811652171 Category : Medical Languages : en Pages : 493
Book Description
This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.
Author: Ulrike S. Stein Publisher: Humana ISBN: 9781071613528 Category : Medical Languages : en Pages : 348
Book Description
This volume provides the most recent developments and methodologies on metastatic process, formation, and detection. Chapters guide readers through functional metastasis in vitro assays, non-mouse and mice metastasis models, methods for imaging metastasis, analyzing the tumor microenvironment, senescence and inflammation with respect to metastasis, methods to investgate the premetastatic/ metastatic, detecting biomarkers in patient, and bioinformatics to simulate the metastatic process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metastasis: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
Author: Sara N. Morrow Publisher: ISBN: Category : Breast Languages : en Pages : 80
Book Description
Breast cancer is defined as a group of malignant cells that originate in the breast and have the potential to spread to distant sites in the body, most commonly the liver, lungs, bones and brain. Many factors increase the risk of breast cancer, including but not limited to environmental factors, age, race, gender and obesity. Methylmercury (MeHg) is an environmental metalloestrogen, a type of metal that mimics the activity of estrogen. Previous studies have shown that low concentrations of MeHg cause breast cancer proliferation via the estrogen receptor (ER), but that at high concentrations it causes cell death. However, the long-term effects of MeHg exposure on breast cancer development are unknown and thus worth researching. Many studies have used xenografts in adult zebrafish (Danio rerio) to research metastatic capability. By using xenografts of mammalian breast cancer cells in zebrafish, the effects of MeHg in an in vivo system can be studied in regards to tumor progression. It is hypothesized that dietary MeHg treatment of zebrafish transplanted with human breast cancer cells will increase tumor size and the number of tumors and will result in micrometastases. In order to test this hypothesis, zebrafish from Professor Lanni’s lab in the Biochemistry Department at Wheaton College were used. First, fish were injected with fluorescently-labeled MCF-7 breast cancer cells. Fish survival and health as well as tumor growth and metastasis were measured. Once it was known that tumors could be successfully grown, an eight-week experiment was designed in which zebrafish were injected with fluorescently-labeled MCF-7 cells. Every week, fish were imaged under a fluorescent scope; after the eight-week period, fish were sacrificed and dissected for tumors. Although further troubleshooting is necessary, a protocol was successfully developed for the injection and growth of breast tumor cells in zebrafish.
Author: Gokhan Dalgin Publisher: Frontiers Media SA ISBN: 2889632482 Category : Languages : en Pages : 157
Book Description
There are only a few vertebrate systems that can be used to model human diseases for biomedical discovery. The zebrafish model provides key advantages over existing models. Their externally developing embryos provide high-throughput non-invasive imaging, chemical screening, forward and reverse genetics, and their regeneration capacity make zebrafish a valuable system for novel discovery. Developmental studies using zebrafish has influenced discoveries in many human health-related conditions. This Research Topic covers all aspects of zebrafish studies, providing developmental mechanisms to human health conditions. The aim of the Research Topic was to foster a platform to bring all levels of zebrafish research including but not limited to development, disease, regeneration, drug screening, bioinformatics and Omics studies.
Author: David M. Langenau
Author: David M. Langenau
Author: David M. Langenau
Author: Samuel Cartner
Author: Kathleen Lindahl Pfaff
Author: FableVision
Author: Prasan R. Bhandari
Author: Ulrike S. Stein
Author: Sara N. Morrow
Author: Gokhan Dalgin
Author: European Molecular Biology Organization