Calcium Dynamics from Randomly Releasing Sparks in Cardiac Myocytes PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Calcium Dynamics from Randomly Releasing Sparks in Cardiac Myocytes PDF full book. Access full book title Calcium Dynamics from Randomly Releasing Sparks in Cardiac Myocytes by Zana Coulibaly. Download full books in PDF and EPUB format.
Author: Zana Coulibaly Publisher: ISBN: Category : Languages : en Pages : 224
Book Description
Organized calcium releases are the meansthrough which the heart regulates the uniform contraction of individual cardiac cells during each heartbeat. At a cardiac cell level, the process involved in the regulation of calcium levels can be modeled using non-linear time-dependent reaction-diffusion equations. This thesis uses various mathematical and analytical tools to study the dynamics of calcium that results from the study of a three-dimensional stochastic fire-diffuse-fire model in long time simulations. To ease the computational complexity that comes with the exploration of sensitive model parameters in long time simulations, we consider one-dimensional model reductions; these reductions lead to the discovery of a parameter region that supports biophysical calcium waves in the 3D model. These biophysical calcium waves are achieved in our model by using large calcium currents. A further exploration of the biophysical boundary in the parameter space reveals a range of parameter values that have a high probability of initiating spiral patterns. By treating the calcium dynamics as one emerging from a network of inhomogeneous point processes, we show that the intrinsic appearance of such patterns in our model is the result of an interplay between the spatial regularity of release sites and the amplitude of calcium release. Neither forced temporal heterogeneity nor spatial irregularity is required.
Author: Zana Coulibaly Publisher: ISBN: Category : Languages : en Pages : 224
Book Description
Organized calcium releases are the meansthrough which the heart regulates the uniform contraction of individual cardiac cells during each heartbeat. At a cardiac cell level, the process involved in the regulation of calcium levels can be modeled using non-linear time-dependent reaction-diffusion equations. This thesis uses various mathematical and analytical tools to study the dynamics of calcium that results from the study of a three-dimensional stochastic fire-diffuse-fire model in long time simulations. To ease the computational complexity that comes with the exploration of sensitive model parameters in long time simulations, we consider one-dimensional model reductions; these reductions lead to the discovery of a parameter region that supports biophysical calcium waves in the 3D model. These biophysical calcium waves are achieved in our model by using large calcium currents. A further exploration of the biophysical boundary in the parameter space reveals a range of parameter values that have a high probability of initiating spiral patterns. By treating the calcium dynamics as one emerging from a network of inhomogeneous point processes, we show that the intrinsic appearance of such patterns in our model is the result of an interplay between the spatial regularity of release sites and the amplitude of calcium release. Neither forced temporal heterogeneity nor spatial irregularity is required.
Author: Nicholas Ayache Publisher: Springer Science & Business Media ISBN: 3642019315 Category : Computers Languages : en Pages : 551
Book Description
This book constitutes the refereed proceedings of the 5th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2009, held in Nice, France in June 2009. The 54 revised full papers presented were carefully reviewed and selected from numerous submissions. The contributions cover topics such as cardiac imaging and electrophysiology, cardiac architecture imaging and analysis, cardiac imaging, cardiac electrophysiology, cardiac motion estimation, cardiac mechanics, cardiac image analysis, cardiac biophysical simulation, cardiac research platforms, and cardiac anatomical and functional imaging.
Author: James Sneyd Publisher: Springer Science & Business Media ISBN: 9783540254393 Category : Mathematics Languages : en Pages : 228
Book Description
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
Author: Donald Bers Publisher: Springer Science & Business Media ISBN: 940100658X Category : Medical Languages : en Pages : 468
Book Description
How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.
Author: Marc Thiriet Publisher: Springer Science & Business Media ISBN: 1461459664 Category : Science Languages : en Pages : 976
Book Description
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
Author: Miguel A. Aon Publisher: Springer Science & Business Media ISBN: 3642385052 Category : Science Languages : en Pages : 375
Book Description
Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.
Author: Publisher: ScholarlyEditions ISBN: 1481677837 Category : Science Languages : en Pages : 79
Book Description
Muscle Cells—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cardiac Myocytes in a concise format. The editors have built Muscle Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiac Myocytes in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Muscle Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Zana Coulibaly
Author: Zana Coulibaly
Author: Julius Guccione
Author: Hans Dierckx
Author: Nicholas Ayache
Author: James Sneyd
Author: 
Author: Donald Bers
Author: Marc Thiriet
Author: Miguel A. Aon
Author: