Calcium Antagonism in Heart and Smooth Muscle PDF Download

Author: International Society for Heart Research. American Section. Meeting
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 376

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From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983

Author: Albrecht Fleckenstein
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 428

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Author: Fleckenstein
Publisher:
ISBN: 9780471845485
Category :
Languages : en
Pages :

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Author: Nicholas Sperelakis
Publisher: Springer
ISBN: 9781461338123
Category : Medical
Languages : en
Pages : 352

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From the Proceedings of the Meeting of the American Section of the International Society for Heart Research (ISHR) at Hilton Head, South Carolina, September 21-24, 1983

Author: Winifred G. Nayler
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 244

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Author: A. Fleckenstein
Publisher: Springer Science & Business Media
ISBN: 3642704999
Category : Medical
Languages : en
Pages : 520

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Held at Boppard, Germany, October 3-6, 1984

Author: Lionel H. Opie
Publisher: Springer Science & Business Media
ISBN: 1461308631
Category : Medical
Languages : en
Pages : 315

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Book Description
Calcium antagonists are now regarded as the most important advance in cardiac drug therapy since the advent of beta-adrenergic blocking agents. Acting ba sically as vasodilators-though with many other com plex mechanisms especially in the case of the anti arrhythmic calcium antagonists, these agents have grown in importance to become among the therapeutic agents of first choice for angina pectoris and hyper tension. The major aim of the present book is to present the clinician with the information needed for the practical use of calcium antagonists. What do all the numerous and often conflicting trials say? Do these agents really work? If so, which agent and in what dose? How do the three front runners, verapamil, nifedipine and diltia zem compare in the efficacy and side-effects with each other? How do the new second generation agents, now entering the North American market, slot in and com pare with the three first-liners? When the gloss is taken away from the advertisements, what is really left? The strong clinical bias of the present book should be complimented by further reading of books slanted towards fundamentals. One of the most important and recent of these is that by Dr Winifred Nayler (Calcium Antagonists, Academic Press, 1988). That book should be basic for essential background knowledge in the area of calcium antagonists. The important basic contribu tions of Fleckenstein deserve emphasis.

Author: A. K. Grover
Publisher: Springer Science & Business Media
ISBN: 1461251729
Category : Science
Languages : en
Pages : 498

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In organizing the present volume, we had two intentions. The first was to present the best current understanding of the mechanisms of calcium mobilization during excitation contraction coupling of smooth muscle at a level suited to the needs of professionals interested in smooth muscle pharmacology and pathophysiology, while remaining appreciable by graduate and medical students. The second intention was to provide in sight into present-day controversies, as well as the latest ad vances achieved by researchers in this field. Thus, we have thor oughly discussed both the techniques and the concepts derived from their application. An attempt has also been made here to answer a number of profoundly important questions: What are the mechanisms and agents responsible for the control of contractility? What are the accompanying changes in the state of intracellular calcium ions and the mechanisms responsible for them? How does the regula tion of contractility occur directly at the level of the actomyosin activity? What role do gap junctions play in cell-to-cell coupling? What are the roles of cholinergic, adrenergic, peptidergic, and nonadrenergic noncholinergic interactions in calcium mobiliza tion in smooth muscle? What changes occur in hypertension? The impact of these recent techniques on future research is also reflected upon.

Author: T. Godfraind
Publisher: Springer Science & Business Media
ISBN: 940111725X
Category : Medical
Languages : en
Pages : 382

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Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades. As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally. This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.

Author: Winifred G. Nayler
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 368

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