Breast Cancer Screening Behaviours and Outcomes in Women with a Family History of Breast And/or Ovarian Cancer in Ontario PDF Download

Author: Meghan Jane Walker
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Austin Chua
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 63

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Purpose: Clinical genetic testing has rapidly evolved to include newer delivery models like telephone-based genetic counseling and client-friendly reports. However, health outcomes of those who have undergone such unique nontraditional approaches are not well understood. Here, we report survey results on health outcomes for recipients of genetic testing through Color Genomics. This survey served as a pilot for a larger future study in collaboration with an academic partner. Methods: We developed a quantitative survey to determine 1) if genetic testing changed screening behavior, 2) if clients shared results with healthcare providers or family members, and 3) how adherent clients are to screening recommendations depending on a nontraditional or traditional channel of testing. Individuals who received the test as a workplace benefit, as well as others who received testing through purchase at home in conjunction with a third party physician order are defined as the nontraditional channel of testing. We defined the traditional channel of genetic testing as individuals who received testing in conjunction with their own healthcare provider. A sample of 249 respondents were included in the study and limited to those who received negative, negative with increased risk due to Gail/Claus scores, and positive results for BRCA1, BRCA2, and/or Lynch syndrome genes MLH1, MSH2, MSH6, PMS2, and EPCAM at least one year prior to study participation. This protocol was approved by the California State University, Stanislaus’ institutional review board under protocol #1819-007. Results: This study has shown among survey participants with a positive result, there is no significant difference between adherence levels before and after testing when comparing channels of testing (p=0.084 and p=0.25). Among the negative with increased risk cohort, there is a significant difference in adherence levels between the two channels before testing (p=0.049), and a nonsignificant difference in adherence levels between the two channels after testing (p=0.34). In the negative cohort, there is no significant difference between adherence levels before and after testing for both channels of testing (p=0.968 and p=0.70). Overall, individuals were very forthcoming when sharing genetic testing results with family members regardless of testing channel. All (n=84) of the positive cohort shared results with family, while an overwhelming majority (93.2% and 89.6%) of the negative with increased risk and negative cohort also shared their results. We focused on sharing reports with providers for the nontraditional channel of testing. Results show 238/249, or 95.6% of the nontraditional cohort, regardless of result type, shared their results with their healthcare providers. Both traditional and nontraditional channels showed similar trends in screening habits after genetic testing regardless of result types. The negative cohorts and negative with increased risk cohorts overwhelmingly responded “No”, 89.6% and 80.7% respectively, when asked about changes to screening. The positive ohort overwhelmingly responded “Yes”, with 83.3% of these respondents reporting changes in screening habits. Conclusions: Findings indicate that, generally, there is no difference between levels of cancer screening adherence between the nontraditional and traditional channels of genetic testing. Consistent with previously reported data, sharing genetic test results between family members and healthcare providers is high. This high rate of information sharing may contribute to improved health outcomes. Risk status comprehension is high in the negative and positive cohorts, which may lead to increased screening and improved health outcomes. Further studies need to be completed to understand potential misunderstanding of risk status and recommended screening guidelines in the negative with increased risk cohort.

Author: Joi L. Morris
Publisher: Rowman & Littlefield
ISBN: 1615927735
Category : Health & Fitness
Languages : en
Pages : 311

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This unique and important guidebook is a single, comprehensive source of information and advice to help women (and some men) at high risk for breast and for ovarian cancer because of family history and genetic profile. One part memoir, three parts "how to" manual, Positive Results explains in a clear and steady manner the myths and realities of "the breast cancer genes." It lays out all the options in easy-to-follow, compassionate language. It will help women and men decide if they want to pursue genetic testing, guide them in interpreting their test results, and give them a sound basis for making the life-saving decisions required to manage their risks. Authors Joi Morris and Dr. Ora Karp Gordon cover all of the latest medical options, including genetic testing for breast cancer risk, breast cancer surveillance, assessing risk, mastectomy and breast reconstruction techniques, ovarian cancer surveillance, surgery, managing menopause, and cancer risks in men who carry mutations on BRCA genes. Along the way, Joi tells her personal story and that of other women and men who have made the gut-wrenching decisions required to survive in this world of astronomical risk. At the age of forty-two, Joi learned that she has a genetic mutation on a gene known as BRCA2. The test results meant that her risk of getting breast cancer could be as high as 84 percent by age seventy, and that her risk for ovarian cancer was also high. Compounding her risk was the fact that her mother had developed breast cancer in her forties. After much research and consultation, the result of which is this book, Joi made the difficult decision of undergoing prophylactic mastectomies.This straightforward and practical approach combined with the poignant personal experience of a woman at risk facing these challenging decisions will provide readers with the feeling that they have had the benefit of a long conversation with both a trusted physician and a friend who has just gone through the same uncertainties they are facing.

Author: Rosalind A. Eeles
Publisher: John Wiley & Sons
ISBN: 1118991060
Category : Medical
Languages : en
Pages : 514

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Winner of the Council Chair's Choice Award at the 2019 British Medical Association Awards. Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

Author: Andrea Leigh Salvador
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 138

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Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309380499
Category : Medical
Languages : en
Pages : 397

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In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Author: Kate Sustersic Gawlik, DNP, APRN-CNP, FAANP
Publisher: Springer Publishing Company
ISBN: 0826164544
Category : Medical
Languages : en
Pages : 794

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The first book to teach physical assessment techniques based on evidence and clinical relevance. Grounded in an empirical approach to history-taking and physical assessment techniques, this text for healthcare clinicians and students focuses on patient well-being and health promotion. It is based on an analysis of current evidence, up-to-date guidelines, and best-practice recommendations. It underscores the evidence, acceptability, and clinical relevance behind physical assessment techniques. Evidence-Based Physical Examination offers the unique perspective of teaching both a holistic and a scientific approach to assessment. Chapters are consistently structured for ease of use and include anatomy and physiology, key history questions and considerations, physical examination, laboratory considerations, imaging considerations, evidence-based practice recommendations, and differential diagnoses related to normal and abnormal findings. Case studies, clinical pearls, and key takeaways aid retention, while abundant illustrations, photographic images, and videos demonstrate history-taking and assessment techniques. Instructor resources include PowerPoint slides, a test bank with multiple-choice questions and essay questions, and an image bank. This is the physical assessment text of the future. Key Features: Delivers the evidence, acceptability, and clinical relevance behind history-taking and assessment techniques Eschews “traditional” techniques that do not demonstrate evidence-based reliability Focuses on the most current clinical guidelines and recommendations from resources such as the U.S. Preventive Services Task Force Focuses on the use of modern technology for assessment Aids retention through case studies, clinical pearls, and key takeaways Demonstrates techniques with abundant illustrations, photographic images, and videos Includes robust instructor resources: PowerPoint slides, a test bank with multiple-choice questions and essay questions, and an image bank Purchase includes digital access for use on most mobile devices or computers

Author: Nadeem Qureshi
Publisher: DIANE Publishing
ISBN: 1437910998
Category : Health & Fitness
Languages : en
Pages : 201

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This systematic review was undertaken to: (1) evaluate the accuracy of patient reporting of cancer family history; (2) identify and evaluate tools designed to capture cancer family history that are applicable to the primary care setting; and (3) identify and evaluate risk assessment tools (RATs) in promoting appropriate management of familial cancer risk in primary care settings. For family history tools (FHxTs) and RATs, studies were limited to those applicable to primary care settings. Conclusions: Informants reporting their cancer family history have greater accuracy for relatives free of cancer than those with cancer. Reporting accuracy may vary among different cancer types. Charts and tables.

Author: Sheri Jacobs Hartman
Publisher:
ISBN:
Category :
Languages : en
Pages :

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ABSTRACT: While sisters of breast cancer patients are at increased risk for developing breast cancer due to their family cancer history and age, little research with first-degree relatives of cancer patients has focused solely on sisters. To address this issue, the current study examined sisters screening and health behaviors and the predictors of these behaviors. In accordance with the Parallel Processing Theory, the current study assessed the relationship of cognitive and emotional factors to screening and health-promoting behaviors among sisters of breast cancer patients. In addition, this study expanded upon the Parallel Processing Theory by also examining the relationship of interpersonal factors to screening and health-promoting behaviors. One-hundred-twenty sisters of breast cancer patients from 89 different families completed questionnaires assessing perceived risk of breast cancer, perceived response efficacy of mammography, diet, and exercise, breast cancer worry, trait anxiety, involvement in sister's cancer care, satisfaction with the sister relationship, mammography screenings, physical activity, and amount of fruits and vegetables consumed. Findings indicated that cognitive, emotional, and relational factors were significantly related to mammography screenings, but not to diet or exercise. Specifically, response efficacy for mammography screening was positively related to mammography screening; while trait anxiety and involvement in sister's care were negatively related to mammography screening. Additional analyses indicated that breast cancer worry had a curvilinear relationship with mammography screenings, such that no relationship was seen for women with lower breast cancer worry; for women with higher levels of worry, the greater their worry, the less likely they were to obtain mammography screenings. Breast cancer worry was also found to interact with involvement in care, such that among women less involved in their sister's care, greater breast cancer worry was associated with having fewer mammography screenings. However, for women more involved in their sister's care, greater breast cancer worry was associated with having more mammography screenings. Future research should further assess whether a teachable moment exists related to the family member's cancer diagnosis and treatment during which to encourage the FDR to engage in screening health-promoting behaviors.

Author:
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ISBN:
Category :
Languages : en
Pages : 19

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This project aims to identify potentially preventable environmental influences on breast and ovarian cancer by focusing on a population of women with genetically inherited predisposition to the disease. This is an extension of our ongoing research into the genetics of breast and ovarian cancer among Jewish women in the New York City area. The IDEA project centered on female relatives of breast cancer patients with confirmed mutations in BRCAl or BRCA2. Each relative provided a blood sample for mutation testing and completed an extensive questionnaire addressing epidemiologic factors in breast cancer risk. Among participants, inherited mutations in BRCAl and BRCA2 were more frequent in women with a younger breast cancer diagnosis and in women with a breast and/or ovarian cancer family history. Breast cancer risks increased over time among women with mutations, suggesting the influence of environmental factors. The experiences and exposures of women with mutations who did and did not develop breast or ovarian cancer were compared to identify factors that ameliorate or exacerbate risk in this high-risk group. These risk factors may be generalized to women without inherited vulnerability to breast or ovarian cancer, as inherited cancer is virtually indistinguishable, clinically and biologically, from its non inherited counterpart.