Facing the Upcoming of Multidrug-Resistant and Extensively Drug-Resistant Bacteria: Novel Antimicrobial Therapies (NATs) PDF Download

Author: Angel León-Buitimea
Publisher: Frontiers Media SA
ISBN: 2889666530
Category : Science
Languages : en
Pages : 136

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Author: Baoming Wu
Publisher: Frontiers Media SA
ISBN: 2832511341
Category : Science
Languages : en
Pages : 129

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Author: Quan Xu
Publisher: Frontiers Media SA
ISBN: 2832523196
Category : Science
Languages : en
Pages : 156

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Author: Bapan Ghosh
Publisher: Frontiers Media SA
ISBN: 2832540147
Category : Science
Languages : en
Pages : 151

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The Lotka-Volterra and the Kermack-McKendrick models are well celebrated and widely recognized in the field of ecology and epidemiology. Several modified ordinary differential equation models have been proposed over the last many decades to rationalize complex biological phenomena. In the current century, researchers have paid much attention to developing new modeling frameworks with delay differential equations, difference equations, fractional order systems, stochastic differential equations, etc. No doubt, these models have emerged many new bifurcations theory and methods which have equally contributed to the advances of Mathematics and interdisciplinary research. It is argued that these new modeling frameworks perform more effectively in analyzing and interpreting results compared to the conventional modeling frameworks with ordinary differential equations. However, implications of emerged bifurcations from new modeling approaches are often less interpreted from a biological viewpoint. Even, there is also a lack of understanding of how a fractional order model, for instance, displays a more realistic scenario to analyze a biological process. Therefore, a more serious justification is essential while modeling any biological event.

Author: Francesco Serrapica
Publisher: Frontiers Media SA
ISBN: 2832552358
Category : Medical
Languages : en
Pages : 238

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Livestock production systems are generally considered to have various negative environmental impacts, including nutrient leaching, and a significant contribution to global warming. In this respect, the reduction of gas or ammonia emissions can be achieved through improved efficiency in the choice of feedstuffs. The use of alternative feeds or additives can contribute to a more energy-efficient ration with lower emissions. Such strategies can contribute to improved animal production and health status. Studies have reported that feed additives such as nitrogen-containing compounds, probiotics, prebiotics, and plant extracts significantly reduce ruminant methane. Moreover, research suggested that fruit pomaces could be a low-cost fibre source in poultry nutrition, and that the inclusion of orange pulp in pigs’ diets can reduce the potential ammonia and methane emissions. To properly evaluate the most adequate reuse strategy it is necessary a specific life cycle assessment for each co-product.

Author: Yuval Tal
Publisher: Frontiers Media SA
ISBN: 2832533582
Category : Medical
Languages : en
Pages : 161

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Publisher: Frontiers Media SA
ISBN: 2832541933
Category : Medical
Languages : en
Pages : 261

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This Research Topic is the second volume of the “Community Series in Novel Biomarkers for Predicting Response to Cancer Immunotherapy". Please see Volume I here. Immunotherapy has revolutionized the treatment of malignancies. Targeting of immune checkpoints cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 (PD-1) and its ligand (PD-L1) has led to improving survival in a subset of patients. Despite their remarkable success, clinical benefit remains limited to only a subset of patients. A significant limitation behind these current treatment modalities is an irregularity in clinical response, which is especially pronounced among checkpoint inhibition. Currently, relevant predictors of cancer immunotherapy response include microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR), expression of PD-L1, tumor mutation burden (TMB), immune genomic characteristics, and tumor infiltrating lymphocytes (TILs). However, none of them have sufficient evidence to be a stratification factor. Moreover, as the combined strategies for effective cancer immunotherapy had been developed in multiple tumors, such as Immunotherapy combined with chemotherapy, radiotherapy, targeted therapy and anti-angiogenesis therapy. Therefore, the development of novel biomarkers endowed with high sensitivity, specificity and accuracy able to identify which patients may truly benefit from the treatment with cancer immunotherapy would allow to refine the therapeutic selection and to better tailor the treatment strategy. This research topic aims to focus on the advances in the discoveries of novel biomarkers for predicting response to cancer immunotherapy in various tumors. We welcome the submission of original research and review articles that include biomarkers in clinical study and applications, as well as technologies or discoveries in experimental approaches.

Author: Artur Bossowski,
Publisher: Frontiers Media SA
ISBN: 283255458X
Category : Medical
Languages : en
Pages : 340

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Thyroid autoimmunity is a common condition in which the immune system mistakenly attacks the thyroid gland, leading to inflammation and damage to the gland. This can result in a range of thyroid pathologies, including hypothyroidism and hyperthyroidism. The prevalence of thyroid autoimmunity is increasing worldwide, and it is more common in women than in men. Recent advances in research on thyroid autoimmunity and pathology have improved our understanding of the mechanisms underlying the development of autoimmune thyroid disease and have identified new targets for therapeutic interventions. These advances have also led to improvements in treatment strategies for patients with thyroid autoimmunity. This Research Topic welcomes contributions of any type (clinical trial, correction, editorial, general commentary, hypothesis & theory, methods, mini review, opinion, original research, perspective, policy and practice reviews, review, study protocol, systematic review, technology and code) on topics around recent studies on new treatment strategies for patients with thyroid autoimmunity, thyroid orbitopathy and selected thyroid cancer.

Author: Arri Eisen
Publisher: Frontiers Media SA
ISBN: 2889761703
Category : Science
Languages : en
Pages : 126

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Author: Daniel Neureiter
Publisher: Frontiers Media SA
ISBN: 2832539661
Category : Science
Languages : en
Pages : 138

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Hepatobiliary cancers, encompassing biliary tract cancer (BTC) and hepatocellular carcinoma (HCC) are highly lethal. Biliary tract cancer is a deadly disease with a very low five-year survival rate. BTC is assumed to be the fifth most common gastrointestinal malignancy and can be categorized into extrahepatic cholangiocarcinoma (EHC), intrahepatic cholangiocarcinoma (IHC) and gallbladder cancer (GBC), based on the anatomic location. Patients suffering from BTC can be currently treated with radiation therapy, palliative or with a combination of two chemotherapeutics, cisplatin and gemcitabine. Hepatocellular carcinoma is the most prevalent form of liver cancers and was responsible for over 830,000 deaths related to cancer worldwide in 2020. HCC is therefore the second most leading cause of cancer deaths globally. Current treatment options encompass targeted therapy with sorafenib, immunotherapy and post-surgery adjuvant chemotherapy. Factors that might contribute to these dismal outcomes are diagnosis at an already late stage, due to unspecific symptoms, limited therapeutic options, lack of targets and understanding of molecular processes during carcinogenesis as well as resistance to current chemotherapy/treatment. Therefore, these current issues need to be further addressed and solutions and alternative approaches must be provided in order to detect these illnesses at an early stage, prolong the survival time of patients suffering from HCC and BTC and overcome general resistance to available treatment options. The aim of this research topic is to provide an overview about mechanisms of therapy resistance, the identification of therapeutic relevant targets and finally, innovative and alternative approaches for treating BTC and HCC successfully.