Blood-Spinal Cord and Brain Barriers in Health and Disease PDF Download

Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Blood-Spinal Cord and Brain Barriers in Health and Disease PDF full book. Access full book title Blood-Spinal Cord and Brain Barriers in Health and Disease by Hari Shanker Sharma. Download full books in PDF and EPUB format.

Blood-Spinal Cord and Brain Barriers in Health and Disease

Blood-Spinal Cord and Brain Barriers in Health and Disease PDF Author: Hari Shanker Sharma
Publisher: Elsevier
ISBN: 0080528228
Category : Medical
Languages : en
Pages : 623

Book Description
Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro

Blood-Spinal Cord and Brain Barriers in Health and Disease

Blood-Spinal Cord and Brain Barriers in Health and Disease PDF Author: Hari Shanker Sharma
Publisher: Elsevier
ISBN: 0080528228
Category : Medical
Languages : en
Pages : 623

Book Description
Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro

The Blood-Brain Barrier in Health and Disease

The Blood-Brain Barrier in Health and Disease PDF Author: William G. Mayhan
Publisher: Biota Publishing
ISBN: 1615047409
Category : Medical
Languages : en
Pages : 77

Book Description
The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.

The Blood-Brain Barrier in Health and Disease, Volume One

The Blood-Brain Barrier in Health and Disease, Volume One PDF Author: Katerina Dorovini-Zis
Publisher: CRC Press
ISBN: 1498727069
Category : Medical
Languages : en
Pages : 418

Book Description
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into

The Blood-Brain Barrier in Health and Disease, Volume Two

The Blood-Brain Barrier in Health and Disease, Volume Two PDF Author: Katerina Dorovini-Zis
Publisher: CRC Press
ISBN: 1498727093
Category : Medical
Languages : en
Pages : 390

Book Description
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into

The Blood-brain Barrier in Health and Disease

The Blood-brain Barrier in Health and Disease PDF Author: Anthony J. Suckling
Publisher: Ellis Horwood
ISBN:
Category : Medical
Languages : en
Pages : 216

Book Description


The Blood Brain Barrier (BBB)

The Blood Brain Barrier (BBB) PDF Author: Gert Fricker
Publisher: Springer
ISBN: 3662437872
Category : Science
Languages : en
Pages : 169

Book Description
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The Blood-Brain Barrier in Health and Disease

The Blood-Brain Barrier in Health and Disease PDF Author: Kason Benson
Publisher: American Medical Publishers
ISBN:
Category : Medical
Languages : en
Pages : 0

Book Description
The blood-brain barrier (BBB) is responsible for the movement of ions, molecules, and cells between the blood and the CNS. This barrier is essential for providing the right environment for healthy neuronal function and also for protecting the CNS from injury and disease. The BBB is made up of three biological components of the brain microvasculature: brain endothelial cells (BECs), astrocyte end-feet, and pericytes (PCs). BECs are essential components of the BBB, responsible for protecting the brain from pathogens while also limiting the flow of circulatory factors. Astrocytes, which are five times the number of neurons in the CNS, provide simple structural and nutritional support for neurons and also contribute to the composition of the BBB. Pericytes play an essential role in angiogenesis, vascular remodeling, vascular tone, and BBB development. Several neurologic diseases such as stroke and neuroinflammatory disorders are affected by the BBB dysfunction. This book presents researches and studies performed by internationally acclaimed experts on the role of blood-brain barrier. It will serve as a valuable source of reference for graduate and post graduate students.

The Cerebral Circulation

The Cerebral Circulation PDF Author: Marilyn J. Cipolla
Publisher: Biota Publishing
ISBN: 1615047239
Category : Medical
Languages : en
Pages : 82

Book Description
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

The Blood-Brain Barrier in Health and Disease

The Blood-Brain Barrier in Health and Disease PDF Author: Katerina Dorovini-Zis
Publisher: CRC Press
ISBN: 9781498727082
Category : Medical
Languages : en
Pages : 0

Book Description
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Introduction to the Blood-Brain Barrier

Introduction to the Blood-Brain Barrier PDF Author: William M. Pardridge
Publisher: Cambridge University Press
ISBN: 0521581249
Category : Medical
Languages : en
Pages : 504

Book Description
The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.