Biophysical Modeling and Experimental Validation of Relative Biological Effectiveness (RBE) for 4He Ion Beam Therapy PDF Download

Author: Stewart Mein
Publisher:
ISBN:
Category :
Languages : en
Pages :

View

Book Description

Author: International Atomic Energy Agency
Publisher:
ISBN: 9789201078070
Category : Ion bombardment
Languages : en
Pages : 0

View

Book Description
This publication covers all the aspects of the relative biological effectiveness (RBE) of ion beams, including laboratory measurements of RBE and the important variables that influence it, dose related quantities and units, and approaches to the clinical use of the concept of RBE based on experimental findings, theoretical models, and previous clinical experience with fast neutrons and ions. This publication is the result of a joint initiative of the IAEA and ICRU (International Commission on Radiation Units and Measurements). It is the only current extensive review of ion beam RBE, and it is expected to be a reference volume for existing and future centres employing ion beams for therapeutic use.

Author: Andrea Mairani
Publisher:
ISBN:
Category :
Languages : en
Pages :

View

Book Description
Since 2009, over 5000 patients have been treated with proton (1H) and carbon (12C) ion beams at the Heidelberg Ion Therapy Center (HIT). By 2020, HIT will begin the first clinical raster-scanning particle therapy program using helium (4He) ions, which exhibit favorable biophysical properties intermediate of clinically used light and heavy ions. Today, a commercial treatment planning system (TPS) for 4He ions does not exist. This calls for an extensive development, testing and verification of a TPS for 4He ions, exploring both physical and biological dose models.This year, a GPU-based dose computation code for particle therapy (FRoG) was developed at HIT. Due to its parallelized computation scheme, sophisticated beam model and outstanding performance in conditions with anatomical complexity, FRoG performs forward dose calculations within minutes (in contrast to full simulation with hour-long runtimes) in excellent agreement with the clinical gold standard Monte Carlo simulations and measurements. Recent efforts focus on dose optimization (both physical and biological) for raster-scanning 4He ions beam therapy. A fully functional TPS within the FRoG framework will be devised and clinically integrated for 4He ion beams.Furthermore, biological phenomena of 4He ion beams remains poorly explored since the shutdown of clinical trials at the Lawrence Berkely National Laboratory in the early 1990u2019s. Potential biophysical and mechanistic approaches to modeling the relative biological effectives (RBE) in the clinic are under investigation in preparations for the first in-man treatment with raster-scanning 4He ion beams.

Author: Sarah Baatout
Publisher: Springer Nature
ISBN: 3031188101
Category : Science
Languages : en
Pages : 687

View

Book Description
This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.

Author: Marco Durante
Publisher: Frontiers Media SA
ISBN: 2889710394
Category : Medical
Languages : en
Pages : 728

View

Book Description

Author: Alfredo Ferrari
Publisher:
ISBN:
Category : Particles (Nuclear physics)
Languages : en
Pages : 410

View

Book Description

Author: Jancy C. McPhee
Publisher: U. S. National Aeronautics & Space Administration
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 396

View

Book Description

Author: Hirohiko Tsujii
Publisher: Springer Science & Business Media
ISBN: 4431544577
Category : Medical
Languages : en
Pages : 284

View

Book Description
This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

Author: C-M Charlie Ma
Publisher: CRC Press
ISBN: 1439816077
Category : Science
Languages : en
Pages : 258

View

Book Description
Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.

Author: Ralph O. Schill
Publisher: Springer
ISBN: 3319957023
Category : Science
Languages : en
Pages : 419

View

Book Description
Offering extensive information on tardigrades, this volume begins with a chapter on the history of tardigrades, from the first description by Goeze in 1773, until 1929, when the most comprehensive monographic approach by E. Marcus was published. Tardigrades’ organ systems, including their integument, body cavity, digestive, muscular, nervous and reproductive systems, as well as their overall external morphology, are summarized in the second chapter. Subsequent chapters present the current state of knowledge on tardigrade phylogeny, biogeography, paleontology, cytology and cytogenetics. In addition, the book provides insights into the ecology of tardigrades in marine, freshwater and terrestrial habitats. The reproduction, development and life cycles are summarized and the extraordinary environmental adaptations of encystment and cyclomorphosis, desiccation tolerance, freezing tolerance and radiation tolerance are discussed in detail. Further chapters provide an overview of key approaches in molecular tardigrade studies and describe techniques for sampling and sample processing. The book closes with a list of tardigrade taxa up to a sub-generic level, including the type species of each genus, the numbers of lower taxa in each taxon, and the main environments in which the taxa were found. Given its depth of coverage, the volume offers an invaluable resource for scientists from various disciplines who plan to research tardigrades, and for all others who are interested in these fascinating animals.