Biopsy Interpretation of the Gastrointestinal Tract Mucosa PDF Download

Author: Elizabeth A. Montgomery
Publisher: Lippincott Williams & Wilkins
ISBN: 1451177844
Category : Medical
Languages : en
Pages : 347

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Book Description
Gastrointestinal mucosal biopsies are an active part of the pathologist’s day and have increased in the past few years as endoscopic screening has become more commonplace. This new full-color Second Edition of Biopsy Interpretation of the Gastrointestinal Tract Mucosa has been expanded into two concise, comprehensive volumes to offer more complete coverage of both non-neoplastic and neoplastic entities. Like the other books in the Biopsy Interpretation Series, these volumes are practical references for pathologists to use when making diagnostic decisions based on biopsy specimens. Volume 2 of this Second Edition focuses on interpretation of neoplastic gastrointestinal mucosal biopsies. Coverage is geared to daily practice and includes mucosal biopsies from the esophagus, stomach, small intestine, large intestine, and anus. A companion website includes all of the 300 print illustrations plus an additional 750 e-figures. Volume 1 focuses on non-neoplastic biopsies and published in November 2011.

Author: M. Priyanthi Kumarasinghe
Publisher: Springer
ISBN: 3319791176
Category : Medical
Languages : en
Pages : 340

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Book Description
The volume of endoscopic biopsies being performed continues to grow rapidly and they now represent one of the most common specimens encountered in routine surgical pathology practice. It is essential to maintain the balance between the speed and accuracy while integrating emerging sophisticated pathology techniques into endoscopic biopsies in routine practice. Microscopic appearance is virtually diagnostic of certain diseases. In others a diagnosis may be rendered only after correlating the microscopic pattern with clinical clues aided by ancillary tests. This text provides a guide to systematic approach of endoscopic biopsies to render a safe, quick and accurate pathological diagnosis in an integrated manner as well as important information that pathologists and clinicians should know to get the best value of endoscopic biopsies. The first chapter introduces the key microscopic features that are normal and abnormal in the gut mucosa as appreciated in an endoscopic biopsy. The second chapter presents a general overview highlighting the neoplastic and non-neoplastic patterns that are common to the entire tubular gut. Because some patterns are common to many sites, an overarching chapter gives the reader a generalized approach, which will be further refined in subsequent site specific chapters. The disease etiologies of each pattern are discussed, with emphasis placed on the most common causes that will be encountered in clinical practice. The subsequent chapters that follow then concentrate on patterns encountered at specific anatomical locations. Under each anatomical location (esophagus, stomach, small intestine and large intestine) site specific patterns of both neoplastic and non-neoplastic conditions are described. Conditions that affect many sites in the gastrointestinal tract are discussed in detail in the most relevant site chapter, but are referred to in other chapters as the reaction pattern/s they produce at that site is discussed. Ancillary tests that are required for a diagnosis of some diseases in particular neoplastic conditions are listed with tips for interpretation. This is presented mostly in a table format to assist day-to-day quick reference. In keeping with recent advances of using small biopsies for testing clinically relevant bio markers, important information that the pathologists and clinicians need to know is highlighted in appropriate sites. Authored by experts in the field, each chapter is presented under headings that include diagnostic features, patterns with relevant endoscopic and clinical clues, traps and overlapping features, and appropriate ancillary tests including clinically relevant molecular signatures in endoscopic biopsies.

Author: Elizabeth A. Montgomery
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781755634
Category : Medical
Languages : en
Pages : 454

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Book Description
This volume of the Biopsy Interpretation Series is a practical, superbly illustrated guide to interpreting gastrointestinal tract mucosal biopsies. The book describes and illustrates the distinguishing features of non-neoplastic lesions, polyps, and neoplasms of the esophagus, stomach, small intestine, colon, and anus. The author addresses the biopsy interpretation issues confronting pathologists in daily practice and offers advice on avoiding pitfalls in biopsy diagnosis. The up-to-date coverage includes detailed information on newly recognized serrated polyps. A bound-in CD-ROM contains 955 full-color digital images of common and rare entities, and includes a quiz mode that is ideal for board exam preparation.

Author: Peter R. Kvietys
Publisher: Morgan & Claypool Publishers
ISBN: 1615041176
Category : Medical
Languages : en
Pages : 127

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Book Description
The microcirculation of the gastrointestinal tract is under the control of both myogenic and metabolic regulatory systems. The myogenic mechanism contributes to basal vascular tone and the regulation of transmural pressure, while the metabolic mechanism is responsible for maintaining an appropriate balance between O2 demand and O2 delivery. In the postprandial state, hydrolytic products of food digestion elicit a hyperemia, which serves to meet the increased O2 demand of nutrient assimilation. Metabolically linked factors (e.g., tissue pO2, adenosine) are primarily responsible for this functional hyperemia. The fenestrated capillaries of the gastrointestinal mucosa are relatively permeable to small hydrolytic products of food digestion (e.g., glucose), yet restrict the transcapillary movement of larger molecules (e.g., albumin). This allows for the absorption of hydrolytic products of food digestion without compromising the oncotic pressure gradient governing transcapillary fluid movement and edema formation. The gastrointestinal microcirculation is also an important component of the mucosal defense system whose function is to prevent (and rapidly repair) inadvertent epithelial injury by potentially noxious constituents of chyme. Two pathological conditions in which the gastrointestinal circulation plays an important role are ischemia/reperfusion and chronic portal hypertension. Ischemia/reperfusion results in mucosal edema and disruption of the epithelium due, in part, to an inflammatory response (e.g., increase in capillary permeability to macromolecules and neutrophil infiltration). Chronic portal hypertension results in an increase in gastrointestinal blood flow due to an imbalance in vasodilator and vasoconstrictor influences on the microcirculation. Table of Contents: Introduction / Anatomy / Regulation of Vascular Tone and Oxygenation / Extrinsic Vasoregulation: Neural and Humoral / Postprandial Hyperemia / Transcapillary Solute Exchange / Transcapillary Fluid Exchange / Interaction of Capillary and Interstitial Forces / Gastrointestinal Circulation and Mucosal Defense / Gastrointestinal Circulation and Mucosal Pathology I: Ischemia/Reperfusion / Gastrointestinal Circulation and Mucosal Pathology II: Chronic Portal Hypertension / Summary and Conclusions / References / Author Biography

Author: Jennifer B. Dressman
Publisher: CRC Press
ISBN: 1420077341
Category : Medical
Languages : en
Pages : 432

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Book Description
Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Author: Kitty Verhoeckx
Publisher: Springer
ISBN: 3319161040
Category : Technology & Engineering
Languages : en
Pages : 341

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Book Description
“Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Author: Joseph Anderson, MD
Publisher: Springer Science & Business Media
ISBN: 1607613980
Category : Medical
Languages : en
Pages : 210

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Book Description
Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0

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Author: Richard Kozarek
Publisher: Springer
ISBN: 3319110772
Category : Medical
Languages : en
Pages : 337

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Book Description
This book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades. Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309082587
Category : Medical
Languages : en
Pages : 172

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Book Description
This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.