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Author: Marta Mattotti Publisher: ISBN: Category : Languages : en Pages : 188
Book Description
After a lesion in the CNS, glial cells play a fundamental role, being the mediators of both the inhibitory and the beneficial response for neural regeneration. The tissue engineering approach consists in the use of biomaterials to help the regeneration and guide the regenerative capable cells to create a permissive environment. The main working hypothesis of this thesis is that we can promote a favourable environment for CNS regeneration identifying material properties which can modulate neuronal cells behaviour. In a first place we analyzed glial and neuronal response to two very different biopolymers, P07A and chitosan. Wettability, surface and mechanical properties were characterized for both materials. Then line pattern of different dimensions in the micrometrical range were introduced. The response of glial cell and neurons were analyzed in terms of cell adhesion, morphology and differentiation state. Finally, we studied the behaviour of glial cells on glass model surfaces functionalized by self assembling monolayers with different wettability (OH, COOH, NH2, CH3), in order to identify the specific role that wettability plays in determining cell response. The dates suggest that the adhesion, the morphology and the differentiation state of neuron and glial cells can be controlled by choosing the proper combination of material properties and physical patterns. Overall, line patterns resulted to be a suitable tool to use in biomaterial design for nerve regeneration. However, the performance of each material must be analyzed with attention, since the combination of material properties, which most of the time is not predictable, play important roles in the biological activity.
Author: Marta Mattotti Publisher: ISBN: Category : Languages : en Pages : 188
Book Description
After a lesion in the CNS, glial cells play a fundamental role, being the mediators of both the inhibitory and the beneficial response for neural regeneration. The tissue engineering approach consists in the use of biomaterials to help the regeneration and guide the regenerative capable cells to create a permissive environment. The main working hypothesis of this thesis is that we can promote a favourable environment for CNS regeneration identifying material properties which can modulate neuronal cells behaviour. In a first place we analyzed glial and neuronal response to two very different biopolymers, P07A and chitosan. Wettability, surface and mechanical properties were characterized for both materials. Then line pattern of different dimensions in the micrometrical range were introduced. The response of glial cell and neurons were analyzed in terms of cell adhesion, morphology and differentiation state. Finally, we studied the behaviour of glial cells on glass model surfaces functionalized by self assembling monolayers with different wettability (OH, COOH, NH2, CH3), in order to identify the specific role that wettability plays in determining cell response. The dates suggest that the adhesion, the morphology and the differentiation state of neuron and glial cells can be controlled by choosing the proper combination of material properties and physical patterns. Overall, line patterns resulted to be a suitable tool to use in biomaterial design for nerve regeneration. However, the performance of each material must be analyzed with attention, since the combination of material properties, which most of the time is not predictable, play important roles in the biological activity.
Author: Fredrick Seil Publisher: Elsevier ISBN: 0323148069 Category : Science Languages : en Pages : 499
Book Description
Nerve, Organ, and Tissue Regeneration: Research Perspectives presents the proceedings of a symposium held in Harpers Ferry, West Virginia, on September 21–24, 1982. This book explores the neural and nonneural areas of regeneration, with emphasis on the nervous system. Organized into six parts encompassing 22 chapters, this compilation of papers examines the commitment of the Veterans Administration to deal with the clinical problem of spinal cord injury by establishing 19spinal cord injury treatment and rehabilitation centers throughout the United States. This book then discusses the characteristics of the neuronal response to axon injury, which vary from cellular hypertrophy and heightened metabolism to cell death. Other chapters consider the three phases of axonal regeneration, including sprout formation, elongation, and maturation. The final chapter deals with the structural and functional alterations that developed when the length of the mammalian intestine is shortened by excision or by-pass of a long segment. This book is a valuable resource for biologists, orthopedic surgeons, and neuroscientists.
Author: Severian Dumitriu Publisher: CRC Press ISBN: 142009470X Category : Medical Languages : en Pages : 922
Book Description
The third edition of a bestseller, this comprehensive reference presents the latest polymer developments and most up-to-date applications of polymeric biomaterials in medicine. Expanded into two volumes, the first volume covers the structure and properties of synthetic and natural polymers as well as bioresorbable hybrid membranes, drug delivery systems, cell bioassay systems, and electrospinning for regenerative medicine. This substantially larger resource includes state-of-the-art research and successful breakthroughs in applications that have occurred in the last ten years.
Author: Tomasz Tański Publisher: BoD – Books on Demand ISBN: 1789235804 Category : Technology & Engineering Languages : en Pages : 160
Book Description
The most effective method of producing nanofibres is the technology of producing in the electrostatic field, which does not require the use of complicated procedures and equipment. Electrospinning allows to produce 1D nanostructures on an industrial scale in a relatively easy and quick way. The method of electrospinning shares the most features with classical technologies in obtaining synthetic fibres that enable forming and generating a stream of previously dissolved or melted polymer and its coaxial stretching, combined with the transition of the polymer from a liquid state to a solid state. In view of the large application possibilities of electrospun fibres, electrospinning is enjoying a dynamically growing interest of scientists, which can be proven by the increasing trend of scientific publications.
Author: Bhupinder Singh Publisher: CRC Press ISBN: 1351138650 Category : Medical Languages : en Pages : 288
Book Description
The present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.
Author: Q Wei Publisher: Elsevier ISBN: 0857095641 Category : Technology & Engineering Languages : en Pages : 447
Book Description
Nanofibers are a flexible material with a huge range of potential applications in such areas as technical textiles. Functional nanofibers and their applications summarises key trends in the processing and applications of these exciting materials. Part one focuses on the types and processing of nanofibers. Beginning with an overview of the principles and techniques involved in their production, it goes on to review core-shell, aligned, porous and gradient nanofibers. The processing and application of composite functional nanofibers, carbon and polymer nanofiber reinforcements in polymer matrix composites, and inorganic functional nanofibers are then explored in detail, before part one concludes with a consideration of surface functionalization. A wide variety of functional nanofiber applications are then reviewed in part two. Following consideration of their use in filtration, drug delivery and tissue engineering applications, the role of functional nanofibers in lithium-ion batteries, sensor applications, protective clothing, food processing and water purification is explored. Discussion of their use in sound absorption, electromagnetic wave attenuation and biomedical and microelectronic applications follows, before a final discussion of future trends. With its distinguished editor and international team of expert contributors, Functional nanofibers and applications is a key text for all those working in the fields of technical textiles, as well as areas using nanofibers such as composites, biomaterials and microelectronics. Summarises key trends in the processing and applications of functional nanofibres in areas such as technical textiles Provides an overview of the principles and techniques involved in the production of nanofibres and reviews core-shell, aligned, porous and gradient nanofibres Considers the use of nanofibres in filtration, drug delivery and tissue engineering applications and the role of functional nanofibres in lithium-ion batteries, sensor applications, protective clothing, food processing and water purification
Author: Buddy D. Ratner Publisher: Academic Press ISBN: 008087780X Category : Medical Languages : en Pages : 1573
Book Description
The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank
Author: Ulrich Meyer Publisher: Springer Science & Business Media ISBN: 3540777555 Category : Medical Languages : en Pages : 1049
Book Description
"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.
Author: Marta Mattotti
Author: Marta Mattotti
Author: Fredrick Seil
Author: Severian Dumitriu
Author: Tomasz Tański
Author: Zhiwei Luo
Author: Bhupinder Singh
Author: Q Wei
Author: Buddy D. Ratner
Author: Ulrich Meyer
Author: National Institutes of Health (U.S.). Division of Research Grants