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Author: Thomas W. Clarkson Publisher: Springer ISBN: 9781461282662 Category : Medical Languages : en Pages : 698
Book Description
This document is the result of a conference on "Biological Monitoring of Metals" held in Rochester, June 2-6, 1986, organized jointly by the Environmental Health Sciences Center of the School of Medicine and Dentistry of the University of Rochester, NY, and the Scientific Committee on the Toxicology of Metals within the International Commission on Occupational Health (ICOH) at the Karolinska Institute and the National (Swedish) Institute of Environmental Medicine and the University of Umea, Sweden. The aim of the Conference was to define and evaluate the scientific basis for the biological monitoring of metals. The conference was co-sponsored by the World Health Organization through its International Program on Chemical Safety and received substantial encouragement and support from the Swedish Work Environmental Fund and the United States Environmental Protection Agency. This was the second conference organized jointly by the Scientific Committee on the Toxicology of Metals and The Toxicology Division of the University of Rochester. The previous joint conference was held in 1982 on the Reproductive and Developmental Toxicity of Metals. In addition, conferences have been organized by each group (see Appendices A and B). Several of these conferences are specially relevant to the topic of the current conference. These include the joint conference mentioned above and the conferences on dose-effect and dose-response relationship held in Tokyo in 1974 and on accumulation of metals held in Buenos Aires in 1972.
Author: Thomas W. Clarkson Publisher: Springer ISBN: 9781461282662 Category : Medical Languages : en Pages : 698
Book Description
This document is the result of a conference on "Biological Monitoring of Metals" held in Rochester, June 2-6, 1986, organized jointly by the Environmental Health Sciences Center of the School of Medicine and Dentistry of the University of Rochester, NY, and the Scientific Committee on the Toxicology of Metals within the International Commission on Occupational Health (ICOH) at the Karolinska Institute and the National (Swedish) Institute of Environmental Medicine and the University of Umea, Sweden. The aim of the Conference was to define and evaluate the scientific basis for the biological monitoring of metals. The conference was co-sponsored by the World Health Organization through its International Program on Chemical Safety and received substantial encouragement and support from the Swedish Work Environmental Fund and the United States Environmental Protection Agency. This was the second conference organized jointly by the Scientific Committee on the Toxicology of Metals and The Toxicology Division of the University of Rochester. The previous joint conference was held in 1982 on the Reproductive and Developmental Toxicity of Metals. In addition, conferences have been organized by each group (see Appendices A and B). Several of these conferences are specially relevant to the topic of the current conference. These include the joint conference mentioned above and the conferences on dose-effect and dose-response relationship held in Tokyo in 1974 and on accumulation of metals held in Buenos Aires in 1972.
Author: M. H. Martin Publisher: Springer Science & Business Media ISBN: 9400973527 Category : Science Languages : en Pages : 486
Book Description
In the past two decades there has been an increasing public awareness of the hazards that exist from the contamination of the environment by toxic substances. 'Heavy metals' and the terrestrial environment are but one facet of the impact of toxic substances on the natural environment, and the use of biological materials for indicating the occurrence of, and continually monitoring the presence of, these materials is a specific topic which is of considerable interest to a diverse range of individuals, organisations and disciplines. It was our intention when we first en visaged this book that it should contain a description of a range of circumstances in which biological monitoring techniques have been employed in the terrestrial environment and that it should be seen as a practical text which dealt with the merits, shortcomings and suitability of biological monitoring materials. Monitoring is, however, a manifold process. It serves not only to provide information on past and present concentrations of toxic materials in various components of the environ ment, but also to provide information on the processes of environmental release, transport, accumulation and toxicity. Indeed, this may be one of the greatest virtues of biological monitoring over other forms of monitor ing. According to the skill of the staff employed in the monitoring procedure, the information that is accrued can have a vastly different value.
Author: Thomas W. Clarkson Publisher: Springer Science & Business Media ISBN: 1461309611 Category : Medical Languages : en Pages : 672
Book Description
This document is the result of a conference on "Biological Monitoring of Metals" held in Rochester, June 2-6, 1986, organized jointly by the Environmental Health Sciences Center of the School of Medicine and Dentistry of the University of Rochester, NY, and the Scientific Committee on the Toxicology of Metals within the International Commission on Occupational Health (ICOH) at the Karolinska Institute and the National (Swedish) Institute of Environmental Medicine and the University of Umea, Sweden. The aim of the Conference was to define and evaluate the scientific basis for the biological monitoring of metals. The conference was co-sponsored by the World Health Organization through its International Program on Chemical Safety and received substantial encouragement and support from the Swedish Work Environmental Fund and the United States Environmental Protection Agency. This was the second conference organized jointly by the Scientific Committee on the Toxicology of Metals and The Toxicology Division of the University of Rochester. The previous joint conference was held in 1982 on the Reproductive and Developmental Toxicity of Metals. In addition, conferences have been organized by each group (see Appendices A and B). Several of these conferences are specially relevant to the topic of the current conference. These include the joint conference mentioned above and the conferences on dose-effect and dose-response relationship held in Tokyo in 1974 and on accumulation of metals held in Buenos Aires in 1972.
Author: National Research Council Publisher: National Academies Press ISBN: 0309102723 Category : Science Languages : en Pages : 317
Book Description
Biomonitoring—a method for measuring amounts of toxic chemicals in human tissues—is a valuable tool for studying potentially harmful environmental chemicals. Biomonitoring data have been used to confirm exposures to chemicals and validate public health policies. For example, population biomonitoring data showing high blood lead concentrations resulted in the U.S. Environmental Protection Agency's (EPA's) regulatory reduction of lead in gasoline; biomonitoring data confirmed a resultant drop in blood lead concentrations. Despite recent advances, the science needed to understand the implications of the biomonitoring data for human health is still in its nascent stages. Use of the data also raises communication and ethical challenges. In response to a congressional request, EPA asked the National Research Council to address those challenges in an independent study. Human Biomonitoring for Environmental Chemicals provides a framework for improving the use of biomonitoring data including developing and using biomarkers (measures of exposure), research to improve the interpretation of data, ways to communicate findings to the public, and a review of ethical issues.
Author: Tom Clarkson Publisher: Springer Science & Business Media ISBN: 1461593468 Category : Medical Languages : en Pages : 830
Book Description
The Permanent Commission and International Association on Occupational Health (PCIAOH) established in 1969 a Subcommittee on the Toxicology of Metals under the chairmanship of Lars Friberg. This committee, which later was named the Scientific Committee on the Toxicology of Metals, has organized a number of previous meetings that have led to publications in three major areas of metal toxicology: a preliminary meeting in Slanchev Bryag, Bulgaria in- 1971, followed by a meeting in 1972 in Buenos Aires, Argentina which produced two reports (Dukes and Friberg, 1971; Task Group on Metal Accumulation, 1973), that discussed the metabolism of metals with special reference to absorption, excretion and biological half-times. The effects and dose-response relationships of toxic metals, including a discussion of general principles, was the second major topic addressed by the Scientific Committee at a meeting in Tokyo in 1974 (Nordberg, 1976). The philosophy of this conference, as well as the previous one in Buenos Aires, was based on the concept of a "threshold dose" for the occurrence of adverse effects. In a conference held in Atlanta, USA in 1980, the scope of discussion on metal effects was broadened to include the role of metals in carcinogenesis. Thus, for the first time, the Scientific Committee took under consideration the possibility of non-threshold relationships (Belman and Nordberg, 1981). In addition, the Scientific Committee on the Toxicology of Metals organized a workshop on metal interactions in Stockholm 1977 (Nordberg et al.
Author: Lars Friberg Publisher: CRC Press ISBN: 1351087274 Category : Science Languages : en Pages : 233
Book Description
The focus of this report is upon information essential to the understanding of the toxic action of cadmium and the relationship between dose (exposure) and effects on human beings and animals. The therapy of cadmium poisoning has not been discussed.This review on cadmium in the environment has been performed under a contract between the U.S. Environmental Protection Agency and the Department of Environmental Hygiene of the Karolinska Institute, Sweden. The report is intended to serve as a background paper for a future Air Quality Criteria document on cadmium. Therefore, particular attention has been given to information relevant for the evaluation of risks due to long-term exposure to low concentrations of cadmium. Acute effects from short-term exposure to high concentrations are dealt with briefly. In vitro studies without bearing on the main problem have not been dealt with.The report is not limited to effects from exposure via inhalation. Newly accessible information, showing that large populations may be exposed considerably via the oral route, can elucidate chronic effects of cadmium in general. Man and animals can be victims of secondary exposure through vehicles such as food and water which have been contaminated by cadmium in air.
Author: Peggy L. Carver Publisher: Walter de Gruyter GmbH & Co KG ISBN: 3110526980 Category : Science Languages : en Pages : 640
Book Description
Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.
Author: National Research Council Publisher: National Academies Press ISBN: 0309044375 Category : Science Languages : en Pages : 224
Book Description
The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.
Author: Hosam El-Din M. Saleh Publisher: BoD – Books on Demand ISBN: 1789233607 Category : Technology & Engineering Languages : en Pages : 414
Book Description
Fundamental societal changes resulted from the necessity of people to get organized in mining, transporting, processing, and circulating the heavy metals and their follow-up products, which in consequence resulted in a differentiation of society into diversified professions and even societal strata. Heavy metals are highly demanded technological materials, which drive welfare and progress of the human society, and often play essential metabolic roles. However, their eminent toxicity challenges the field of chemistry, physics, engineering, cleaner production, electronics, metabolomics, botany, biotechnology, and microbiology in an interdisciplinary and cross-sectorial manner. Today, all these scientific disciplines are called to dedicate their efforts in a synergistic way to avoid exposure of heavy metals into the eco- and biosphere, to reliably monitor and quantify heavy metal contamination, and to foster the development of novel strategies to remediate damage caused by heavy metals.
Author: Thomas W. Clarkson
Author: Thomas W. Clarkson
Author: M. H. Martin
Author: Thomas W. Clarkson
Author: National Research Council
Author: Tom Clarkson
Author: Lars Friberg
Author: Peggy L. Carver
Author: National Research Council
Author: Frederic R. Siegel
Author: Hosam El-Din M. Saleh