Biochemistry of S-adenosylmethionine and Related Compounds PDF Download

Author: Earl Usdin
Publisher: Springer
ISBN: 1349063436
Category : Science
Languages : en
Pages : 736

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Author: Robert M Blumenthal
Publisher: World Scientific
ISBN: 9814494976
Category : Science
Languages : en
Pages : 419

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Book Description
This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.

Author: Ryan J. Huxtable
Publisher: Springer Science & Business Media
ISBN: 147579438X
Category : Science
Languages : en
Pages : 454

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Book Description
There can be few elements with a biochemistry as coherent as that of sulfur. This important element is crucial to myriad aspects of metabo lism, catalysis, and structure. The plurality of functions in which sulfur is involved derives squarely from the numerous oxidation states in which it may exist, some having great stability, some being capable of ready redox interconversions, and yet others having great instability. As a result, the flux of sulfur from the geosphere through the various kingdoms of life leaves few biochemical processes unaffected. Although there are large gaps in the fabric of our basic knowledge of sulfur biochemistry, it is sufficiently framed to allow a unified and organized story, a story which many of the best-known names in bio chemistry have helped to write. It has been both a task and a privilege to try and summarize this story, one that is enormous, complex, fast moving, still developing and, above all, exciting. I suppose that no mo nographer of such a vast subject could be satisfied with his efforts. It is unfortunately probable that in attempting this task I have made as many errors as a Stilton cheese has blue streaks, and as many omissions as a Swiss cheese has holes. Perfection is not to be achieved in a monograph. Inasmuch as I have succeeded, the credit belongs to those whose efforts gave us the knowledge we have. Where I have failed, the fault is only mine.

Author:
Publisher: Academic Press
ISBN: 9780128127940
Category : Science
Languages : en
Pages : 0

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Book Description
Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.

Author: Stephen C. Mitchell
Publisher: CRC Press
ISBN: 0203362527
Category : Medical
Languages : en
Pages : 236

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This text focuses on the biological interactions of sulphur compounds which arise specifically from the presence of the sulphur atom within the molecule. The book opens with introductory chapters on the chemistry and biology of sulphur, before tackling the field by introducing compounds which share a common chemical combination. In general, following a description of the uses and impact upon the biological field, specific chemical group characteristics are discussed together with the biological activity and structure-activity relationships where known. The toxicity of such compounds, their consequences in biochemical and clinical terms, and their mechanisms of biological interaction are then addressed.

Author: Ralph Carmel
Publisher: Cambridge University Press
ISBN: 9780521653190
Category : Medical
Languages : en
Pages : 558

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Book Description
This is an unusually comprehensive 2001 account of the broad range of medical implications of homocysteine.

Author: Ronald T. Borchardt
Publisher: Springer Science & Business Media
ISBN: 1461250129
Category : Medical
Languages : en
Pages : 463

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Book Description
This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans methylation inhibitors (Section E).

Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1956

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Author: Z. M. Bacq
Publisher: Elsevier
ISBN: 1483181626
Category : Medical
Languages : en
Pages : 694

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Book Description
Fundamentals of Biochemical Pharmacology explains the molecular aspects of drugs and the changes in bio-chemical systems. The cellular movements that result from such changes are also evaluated. Biochemical lesion is extensively defined in the book. A discussion on electromagnetic radiation is also provided. A chapter of the book is devoted to the principles of electronic and nuclear magnetic resonance. The principles and applications of mass spectrometry and combined gas chromatography are then discussed. The scientific advances made with the use of immunological methods are the focus of a section of the book. Another section provides an introduction to the kinetic properties of reactions made by enzymes. The process called homogenization is clearly explained along with a discussion on the use of electron microscopy. Autoradiography shows the distribution of compounds at the subcellular level. The theoretical background of molecular spectroscopy is presented completely. The book is intended for chemists, biochemists, physicists, micro-biologists, zoologists, and botanists .

Author: Graham H. Coombs
Publisher: CRC Press
ISBN: 074840001X
Category : Medical
Languages : en
Pages : 656

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Book Description
A compilation of articles on protozoological biochemistry which reviews the subject area and offers information on current research. Included in the Topics Covered Are Energy Metabolism Of Anaerobic Parasitic Protists, proteinases of African