Biochemistry and Neurological Disease PDF Download

Author: Alan Nelson Davison
Publisher: Wiley-Blackwell
ISBN: 9780632003778
Category : Biochemistry
Languages : en
Pages : 325

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Author: Philip Gordon Strange
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 368

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Book Description
This textbook gives students of neuroscience, psychology, and related subjects a thorough introduction to this important topic and a foundation for future study. Key concepts are explained clearly and, by bridging the gap between basic and clinical sciences, the book provides a new perspective on brain function and brain disorders. Its unique approach means that it will give researchers new insights into their subject, as well as acting as a concise review and reference text.

Author: J. Cumings
Publisher: Springer Science & Business Media
ISBN: 1468419560
Category : Medical
Languages : en
Pages : 301

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Book Description
Within recent years basic knowledge concerning the chemistry, and the metabolic processes taking place in the brain, spinal cord, peripheral nerves and muscles has increased in a remarkable manner. As a consequence some very important books have been published both in America and in Europe in which some, at least, of this information has become available in an easily readable form to an ever increasing group of laboratory and scientific workers. The application of such studies in a variety of neurological diseases can now be made, thus making possible an explanation of many of the clinical and pathological peculiarities that have been known for decades. Although a few small manuals have already been published, combining both biochemical and clinical aspects of such disorders and these have been studied by neurologists and chemical pathologists throughout the world, yet a volume devoted exclusively to the biochemistry of neurological diseases has not yet been readily available. The present volume is an attempt to remedy this omission in relation to just a few of the conditions. Individual writers of each of the six chapters have been chosen who are intimately concerned both with biochemistry and with its application to disease in man. Each author has been responsible for the accuracy of his chapter together with appropriate references from the literature, but the Editor does not necessarily concur with all the opinions expressed by the authors.

Author: Touqeer Ahmed
Publisher: Bentham Science Publishers
ISBN: 1681088843
Category : Science
Languages : en
Pages : 196

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Book Description
Aluminium is a chemical element present in earth’s crust and it is a known environmental toxin which has been found to be associated with various neurological disorders. Aluminium has been found to be a very strong risk factor for the development of Alzheimer’s disease. Biochemical Mechanisms of Aluminium Induced Neurological Disorders explains the association of aluminium with neurological disorders. The book introduces the reader to sources of aluminium exposure, followed by an explanation of pharmacokinetics of aluminium and the different biochemical pathways that cause neurological effects. Chapters cover the typical mechanisms associated with aluminium neurotoxicity such as synaptic impairment as well as recent topics of interest such as the role of aluminum in impairing blood-brain barrier functions. Separate chapters which cover clinical evidence of aluminium toxicity and its management are also included in the book. Biochemical Mechanisms of Aluminium Induced Neurological Disorders is a concise, yet informative reference on the subject of aluminium neurotoxicity for all readers, whether they are students of biochemistry, pharmacology and toxicology, clinical neurologists, environmentalists interested in metal pollution or general readers who want to learn about the toxic effects of aluminium in humans.

Author: Jacques Fantini
Publisher: Academic Press
ISBN: 0128004924
Category : Medical
Languages : en
Pages : 398

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Book Description
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer’s, Creutzfeldt-Jakob’s and Parkinson’s. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. Written to provide a "hands-on" approach for readers Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings Step-by-step guide to memorize and draw lipid structures Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique

Author: Kevin K. W. Wang
Publisher: CRC Press
ISBN: 1482239833
Category : Medical
Languages : en
Pages : 647

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This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies

Author: Sarfraz Ahmed
Publisher: Springer Nature
ISBN: 303076320X
Category : Medical
Languages : en
Pages : 559

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Book Description
This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included.

Author: John Nathaniel Cumings
Publisher:
ISBN: 9780397600779
Category :
Languages : en
Pages : 336

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Author: Astrid Sigel
Publisher: John Wiley & Sons
ISBN: 0470028106
Category : Science
Languages : en
Pages : 488

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Book Description
About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Author: Lieberman
Publisher: CRC Press
ISBN: 9780824790820
Category : Medical
Languages : en
Pages : 408

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Emphasizing the role of monoamine oxidase (MAO) in the etiology and pathogenesis of Parkinson's disease and Alzheimer's disease, this up-to-date reference describes the genetics, physiology, biochemistry, pharmacology, and clinical aspects of this very important class of enzymes. Details how the interaction between selegiline (deprenyl) and MAO may retard the progression of neurodegenerative disorders! Providing the latest theories on how selegiline operates, Monoamine Oxidase Inhibitors in Neurological Diseases presents fundamental information on MAO types A and B examines the distribution of MAO A and B in the normal human brain investigates the effects of disease and aging on MAO A and B analyzes a critical role for MAO in the toxic action in Parkinson's disease elucidates selegiline's novel ability to delay the progression or repair the damage of dopaminergic neurons discusses the usefulness of MAO inhibitors in psychiatric disease and more!