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Author: Nimrod Missael Garcia Hernandez Publisher: ISBN: Category : Electronic dissertations Languages : en Pages : 151
Book Description
Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I have realized single-chip multi-spectral imagers with 1000-fold higher sensitivity and 7-fold better spatial co-registration accuracy compared to clinical imaging systems in current use by monolithically integrating spectral tapetal and polarization filters with an array of vertically stacked photodetectors. These imaging sensors yield the unique capabilities of imaging simultaneously color, polarization, and multiple fluorophores for near-infrared fluorescence imaging. Preclinical and clinical data demonstrate seamless integration of this technologies in the surgical work flow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes, respectively. Due to its low cost, the bio-inspired sensors will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.
Author: Nimrod Missael Garcia Hernandez Publisher: ISBN: Category : Electronic dissertations Languages : en Pages : 151
Book Description
Image-guided surgery (IGS) can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky, costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities to distinguish cancerous from healthy tissue. In my thesis, I have addressed these challenges in IGC by mimicking the visual systems of several animals to construct low power, compact and highly sensitive multi-spectral and color-polarization sensors. I have realized single-chip multi-spectral imagers with 1000-fold higher sensitivity and 7-fold better spatial co-registration accuracy compared to clinical imaging systems in current use by monolithically integrating spectral tapetal and polarization filters with an array of vertically stacked photodetectors. These imaging sensors yield the unique capabilities of imaging simultaneously color, polarization, and multiple fluorophores for near-infrared fluorescence imaging. Preclinical and clinical data demonstrate seamless integration of this technologies in the surgical work flow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes, respectively. Due to its low cost, the bio-inspired sensors will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care.
Author: Shengkui Gao Publisher: ISBN: Category : Electronic dissertations Languages : en Pages : 142
Book Description
Image guided surgery (IGS) utilizes emerging imaging technologies to provide additional structural and functional information to the physician in clinical settings. This additional visual information can help physicians delineate cancerous tissue during resection as well as avoid damage to near-by healthy tissue. Near-infrared (NIR) fluorescence imaging (700 nm to 900 nm wavelengths) is a promising imaging modality for IGS, namely for the following reasons: First, tissue absorption and scattering in the NIR window is very low, which allows for deeper imaging and localization of tumor tissue in the range of several millimeters to a centimeter depending on the tissue surrounding the tumor. Second, spontaneous tissue fluorescence emission is minimal in the NIR region, allowing for high signal-to-background ratio imaging compared to visible spectrum fluorescence imaging. Third, decoupling the fluorescence signal from the visible spectrum allows for optimization of NIR fluorescence while attaining high quality color images. Fourth, there are two FDA approved fluorescent dyes in the NIR region--namely methylene blue (MB) and indocyanine green--which can help to identify tumor tissue due to passive accumulation in human subjects. The aforementioned advantages have led to the development of NIR fluorescence imaging systems for a variety of clinical applications, such as sentinel lymph node imaging, angiography, and tumor margin assessment. With these technological advances, secondary surgeries due to positive tumor margins or damage to healthy organs can be largely mitigated, reducing the emotional and financial toll on the patient. Currently, several NIR fluorescence imaging systems (NFIS) are available commercially or are undergoing clinical trials, such as FLARE, SPY, PDE, Fluobeam, and others. These systems capture multi-spectral images using complex optical equipment and are combined with real-time image processing to present an augmented view to the surgeon. The information is presented on a standard monitor above the operating bed, which requires the physician to stop the surgical procedure and look up at the monitor. The break in the surgical flow sometimes outweighs the benefits of fluorescence based IGS, especially in time-critical surgical situations. Furthermore, these instruments tend to be very bulky and have a large foot print, which significantly complicates their adoption in an already crowded operating room. In this document, I present the development of a compact and wearable goggle system capable of real-time sensing of both NIR fluorescence and color information. The imaging system is inspired by the ommatidia of the monarch butterfly, in which pixelated spectral filters are integrated with light sensitive elements. The pixelated spectral filters are fabricated via a carefully optimized nanofabrication procedure and integrated with a CMOS imaging array. The entire imaging system has been optimized for high signal-to-background fluorescence imaging using an analytical approach, and the efficacy of the system has been experimentally verified. The bio-inspired spectral imaging sensor is integrated with an FPGA for compact and real-time signal processing and a wearable goggle for easy integration in the operating room. The complete imaging system is undergoing clinical trials at Washington University in the St. Louis Medical School for imaging sentinel lymph nodes in both breast cancer patients and melanoma patients.
Author: Nan Cui Publisher: ISBN: Category : Electronic dissertations Languages : en Pages : 101
Book Description
Background: Cancer remains a major public health problem worldwide and poses a huge economic burden. Near-infrared (NIR) fluorescence image-guided surgery (IGS) utilizes molecular markers and imaging instruments to identify and locate tumors during surgical resection. Unfortunately, current state-of-the-art NIR fluorescence imaging systems are bulky, costly, and lack both fluorescence sensitivity under surgical illumination and co-registration accuracy between multimodal images. Additionally, the monitor-based display units are disruptive to the surgical workflow and are suboptimal at indicating the 3-dimensional position of labeled tumors. These major obstacles have prevented the wide acceptance of NIR fluorescence imaging as the standard of care for cancer surgery. The goal of this dissertation is to enhance cancer treatment by developing novel image sensors and presenting the information using holographic augmented reality (AR) display to the physician in intraoperative settings.Method: By mimicking the visual system of the Morpho butterfly, several single-chip, color-NIR fluorescence image sensors and systems were developed with CMOS technologies and pixelated interference filters. Using a holographic AR goggle platform, an NIR fluorescence IGS display system was developed. Optoelectronic evaluation was performed on the prototypes to evaluate the performance of each component, and small animal models and large animal models were used to verify the overall effectiveness of the integrated systems at cancer detection.Result: The single-chip bio-inspired multispectral logarithmic image sensor I developed has better main performance indicators than the state-of-the-art NIR fluorescence imaging instruments. The image sensors achieve up to 140 dB dynamic range. The sensitivity under surgical illumination achieves 6 x 108 [mu]V/(mW/cm2), which is up to 25 times higher. The signal-to-noise ratio is up to 56 dB, which is 11 dB greater. These enable high sensitivity fluorescence imaging under surgical illumination. The pixelated interference filters enable temperature-independent co-registration accuracy between multimodal images. Pre-clinical trials with small animal model demonstrate that the sensor can achieve up to 95% sensitivity and 94% specificity with tumor-targeted NIR molecular probes. The holographic AR goggle provides the physician with a non-disruptive 3-dimensional display in the clinical setup. This is the first display system that co-registers a virtual image with human eyes and allows video rate image transmission. The imaging system is tested in the veterinary science operating room on canine patients with naturally occurring cancers. In addition, a time domain pulse-width-modulation address-event-representation multispectral image sensor and a handheld multispectral camera prototype are developed.Conclusion: The major problems of current state-of-the-art NIR fluorescence imaging systems are successfully solved. Due to enhanced performance and user experience, the bio-inspired sensors and augmented reality display system will give medical care providers much needed technology to enable more accurate value-based healthcare.
Author: Michael R. Hamblin Publisher: Academic Press ISBN: 0128028599 Category : Science Languages : en Pages : 562
Book Description
Imaging in Dermatology covers a large number of topics in dermatological imaging, the use of lasers in dermatology studies, and the implications of using these technologies in research. Written by the experts working in these exciting fields, the book explicitly addresses not only current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today, along with the cellular and molecular effects of these technologies. - Outlines the fundamentals of imaging and lasers for dermatology in clinical and research settings - Provides knowledge of current and future applications of dermatological imaging and lasers - Coherently structured book written by the experts working in the fields covered
Author: Giuliano Mariani Publisher: Springer Science & Business Media ISBN: 0387383271 Category : Medical Languages : en Pages : 319
Book Description
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
Author: Orly Yadid-Pecht Publisher: Springer Science & Business Media ISBN: 1402079621 Category : Science Languages : en Pages : 251
Book Description
The idea of writing a book on CMOS imaging has been brewing for several years. It was placed on a fast track after we agreed to organize a tutorial on CMOS sensors for the 2004 IEEE International Symposium on Circuits and Systems (ISCAS 2004). This tutorial defined the structure of the book, but as first time authors/editors, we had a lot to learn about the logistics of putting together information from multiple sources. Needless to say, it was a long road between the tutorial and the book, and it took more than a few months to complete. We hope that you will find our journey worthwhile and the collated information useful. The laboratories of the authors are located at many universities distributed around the world. Their unifying theme, however, is the advancement of knowledge for the development of systems for CMOS imaging and image processing. We hope that this book will highlight the ideas that have been pioneered by the authors, while providing a roadmap for new practitioners in this field to exploit exciting opportunities to integrate imaging and “smartness” on a single VLSI chip. The potential of these smart imaging systems is still unfulfilled. Hence, there is still plenty of research and development to be done.
Author: National Defense University Publisher: NDU Press ISBN: 1780390408 Category : History Languages : en Pages : 356
Book Description
Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.
Author: Gábor Horváth Publisher: Springer ISBN: 3642547184 Category : Science Languages : en Pages : 652
Book Description
This book covers advances made since the 2004 Springer volume “Polarized Light in Animal Vision” edited by Horvath and Varju, but also provides reviews and synopses of some areas. Part I examines polarization sensitivity across many animal taxa including vertebrates and invertebrates and details both terrestrial and aquatic life. Part II is devoted to the description of polarized light in nature and explores how the physics of light must be taken into account when understanding how polarized light is detected by the visual system. This includes underwater polarization due to scattering; polarization patterns reflected from freshwater bodies; polarization characteristics of forest canopies; normal and anomalous polarization patterns of the skies; skylight polarization transmitted through Snell’s window and both linearly and circularly polarized signals produced by terrestrial and aquatic animals. This Part also examines polarized “light pollution” induced by anthropogenic factors such as reflection off asphalt surfaces, glass panes, car bodies, and other man-made structures that are now known to form ecological traps for polarotactic insects. Part III surveys some of the practical applications of polarization vision including polarization-based traps for biting insects, ground-based polarimetric cloud detectors and an historical examination of the navigational abilities of Viking seafarers using the sky polarization compass. The deterrent qualities of ungulate pelage to polarization-sensitive biting insects is also examined in this section.
Author: Nimrod Missael Garcia Hernandez
Author: Nimrod Missael Garcia Hernandez
Author: Shengkui Gao
Author: Nan Cui
Author: Steven Michael Blair
Author: Michael R. Hamblin
Author: Giuliano Mariani
Author: Alexander A. Oraevsky
Author: Orly Yadid-Pecht
Author: National Defense University
Author: Gábor Horváth