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Beyond Superficial Targeting

Beyond Superficial Targeting PDF Author: Robin L. Shepard
Publisher:
ISBN:
Category :
Languages : en
Pages : 384

Book Description


Beyond Superficial Targeting

Beyond Superficial Targeting PDF Author: Robin L. Shepard
Publisher:
ISBN:
Category :
Languages : en
Pages : 384

Book Description


Proceedings

Proceedings PDF Author:
Publisher:
ISBN:
Category : Nonpoint source pollution
Languages : en
Pages : 272

Book Description


Digital Marketing Content Creation: Engaging Your Target Audience

Digital Marketing Content Creation: Engaging Your Target Audience PDF Author: John Lewis
Publisher: Boost Template LLC
ISBN:
Category : Business & Economics
Languages : en
Pages : 121

Book Description
Unleash the Digital Marketing Revolution! Are you ready to revolutionize your digital marketing game? Dive into the world of digital marketing and discover the strategies, tactics, and techniques that will take your business to the next level. With 5.18 billion internet users and 4.8 billion social media users worldwide, the digital landscape offers unprecedented opportunities to connect with your target audience. But success requires more than just a flashy website. It demands a clear path and a focus on what truly matters. In this book, you'll explore the role of content in digital marketing – the lifeblood that fuels interactions between businesses and their audience. Learn how to create compelling content that engages, educates, and entertains, transcending traditional advertising boundaries to build genuine connections and trust. Discover the power of compelling content in driving engagement and conversions. Captivate attention, create emotional connections, encourage interaction, and provide real value to your audience. By showcasing your expertise, integrating persuasive calls to action, and amplifying your reach through organic sharing, you'll unlock the full potential of your digital marketing efforts. Don't miss out on the digital marketing revolution. Invest your time and resources in crafting high-quality, unique, and valuable content that resonates with your audience. Get ready to engage, captivate, and convert with compelling content. It's time to make a lasting impact in the digital world.

Organelle and Molecular Targeting

Organelle and Molecular Targeting PDF Author: Lara Scheherazade Milane
Publisher: CRC Press
ISBN: 1000505936
Category : Science
Languages : en
Pages : 511

Book Description
We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Clinical Target Volumes in Conformal and Intensity Modulated Radiation Therapy

Clinical Target Volumes in Conformal and Intensity Modulated Radiation Therapy PDF Author: Vincent Gregoire
Publisher: Springer Science & Business Media
ISBN: 3662062704
Category : Medical
Languages : en
Pages : 253

Book Description
Conformal radiation therapy represents a new challenge. It offers the prospect of either increasing the radiation dose to target tissues while delivering a similar dose to organs at risk, or reducing the dose to organs at risk while maintaining the dose to target tissues. First, lymph node areas at risk are established using the available data from pathological examination. Then, based on a three-dimensional description of the anatomical regions, guidelines for the delineation of the clinical target volumes are proposed. The data presented should enable the reader to make appropriate decisions regarding the selection and delineation of the target volumes when confronted with the most frequent tumor types and sites.

Calixarenes and Beyond

Calixarenes and Beyond PDF Author: Placido Neri
Publisher: Springer
ISBN: 3319318675
Category : Science
Languages : en
Pages : 1053

Book Description
Contributions featuring the chemistry and applications of a family of macrocyclic compounds collectively known as 'calixarenes' are presented in this edited volume. The arsenal of structures based on calixarenes provides tools which are effective in numerous areas of supramolecular chemistry. The Editors have compiled a timely volume which contains up to date, high calibre contributions from a large number of international authors. A broad perspective on the progress and future of calixarene chemistry is presented. Aimed at students and researchers active in Supramolecular Chemistry.

Targeting Treatment of Soft Tissue Sarcomas

Targeting Treatment of Soft Tissue Sarcomas PDF Author: J. Verweij
Publisher: Springer Science & Business Media
ISBN: 1402078560
Category : Medical
Languages : en
Pages : 185

Book Description
- Discusses the latest drug treatments in the field - Gleevec arranged a bulk sale for this title - Written by leaders in the industry

Capacity beyond Coercion

Capacity beyond Coercion PDF Author: Susan L. Ostermann
Publisher: Oxford University Press
ISBN: 0197661130
Category : Political Science
Languages : en
Pages : 249

Book Description
State capacity is often equated with coercion. However, history has shown that it is extremely difficult for states with weak capacity to ensure compliance with their laws. In Capacity beyond Coercion, Susan L. Ostermann examines the largely unexplored capacities that allow coercively weak states to promote law-following behavior. Utilizing extensive data collected in adjacent districts in India and Nepal, she demonstrates how coercively weak states can significantly increase compliance by behaving pragmatically and designing implementation strategies around known barriers to compliance. In particular, she examines variation in compliance with conservation, education, and child labor regulations, investigating the mechanisms by which the Indian and Nepali states have, despite limited enforcement capacity, secured compliance with regulations that run counter to customary norms and to the self-interest of target populations. She argues that one such barrier is imperfect legal knowledge and shows how states that have engaged in what she terms "regulatory pragmatism" may circumvent this compliance barrier. They do so by designing implementation strategies for on-the-ground realities. Exploring two such efforts--delegated enforcement and information dissemination through local leaders, Ostermann demonstrates that states that suffer from limited coercive capacity but behave pragmatically can still bring about large-scale compliance. Given that many states have weak enforcement capacity, the findings in Capacity beyond Coercion point a way forward for more effective and responsive governance throughout the developing world.

Combat, Vol. 1

Combat, Vol. 1 PDF Author: Stephen Coonts
Publisher: Forge Books
ISBN: 1429942002
Category : Fiction
Languages : en
Pages : 418

Book Description
An historic landmark work, depicting war as it is and soon will be-the shape of war to come. Featuring new short novels by: Larry Bond, who explores the wild frontier of space warfare, where American forces fight a tenacious enemy which threatens every free nation on Earth. Dale Brown, taking us into the seldom-seen world of the military review board, and shows us how the future career of an EB-52 Megafortress pilot can depend on a man he's never met. And David Hagberg, who brings us another Kirk McGarvey adventure, in which the C.I.A. director becomes entangled in the rising tensions between China and Taiwan. When a revolutionary leader is rescued from a Chinese prison, the Chinese government pushes the United States to the brink of war, and McGarvey has to make a choice with the fate of the world hanging in the balance. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

Wealth Building Journal

Wealth Building Journal PDF Author: Black Enterprise
Publisher: John Wiley & Sons
ISBN: 0471205427
Category : Business & Economics
Languages : en
Pages : 225

Book Description
A personal and rewarding journey for building wealth and security Inspired by the Black Enterprise Declaration of Financial Empowerment and the highly praised wealth-building initiative that have sparked a renewed financial commitment among African Americans, Wealth Building Journal is a dynamic guide for taking your finances into your own hands and realizing your own version of the American dream. The editors of Black Enterprise magazine provide you with the steps and tools essential to making your aspirations come true, including strategies for becoming financially responsible, reducing debt, saving and investing, and leveraging your spending dollars. You'll not only design the life you and your family deserve, you'll see how your efforts can help build a healthier, more powerful, and more influential African-American community-one person at a time. The book offers you: * Motivational quotes from famous African Americans, such as Reginald F. Lewis, John H. Johnson, Muhammad Ali, and Maxine Waters * Daily affirmations/activities to help transform your thinking and embrace new resolutions * Eye-opening and illuminating anecdotes and success stories * The Declaration of Financial Empowerment, a self-empowerment tool for anyone committed to making changes to his/her lifestyle Whether you are struggling financially or are very well off-and regardless of your degree of knowledge or experience-Wealth Building Journal is your coach and companion as well as your personal call to arms for developing a solid and rewarding lifelong approach to money. Start today.