Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders PDF Download
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Author: W. E. Crusio Publisher: ISBN: Category : Behavior genetics Languages : en Pages : 0
Book Description
"The first volume in the new Cambridge Handbooks in Behavioral Genetics, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically-modified or pharmacologically-treated animals, and in the interpretation and analyses of the results obtained. Offering a comprehensive overview of the genetics of naturally-occurring variation in mouse behavior; from perception and spontaneous behaviors, such as exploration, aggression, social interactions and motor behaviors to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike"--
Author: Susanna Pietropaolo Publisher: Cambridge University Press ISBN: 131606140X Category : Science Languages : en Pages : 471
Book Description
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Wim E. Crusio Publisher: Cambridge University Press ISBN: 1107355575 Category : Science Languages : en Pages : 361
Book Description
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Author: Byron C. Jones Publisher: CRC Press ISBN: 9781420048384 Category : Science Languages : en Pages : 416
Book Description
Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print. Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals. Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes. The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.
Author: Jacqueline N. Crawley Publisher: John Wiley & Sons ISBN: 0471471925 Category : Science Languages : en Pages : 540
Book Description
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Author: W. E. Crusio Publisher: ISBN: 9781107342200 Category : Nature Languages : en Pages : 362
Book Description
"The first volume in the new Cambridge Handbooks in Behavioral Genetics, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically-modified or pharmacologically-treated animals, and in the interpretation and analyses of the results obtained. Offering a comprehensive overview of the genetics of naturally-occurring variation in mouse behavior; from perception and spontaneous behaviors, such as exploration, aggression, social interactions and motor behaviors to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike"--
Author: Valter Tucci Publisher: John Wiley & Sons ISBN: 111854076X Category : Medical Languages : en Pages : 651
Book Description
The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour. Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., “systems biology” approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.
Author: Fergus Craik Publisher: Psychology Press ISBN: 1317775066 Category : Psychology Languages : en Pages : 776
Book Description
The chapters in this volume are the edited versions of invited addresses to the XXVI International Congress of Psychology held in Montréal in August 1996. As one major goal of the Congress was to promote communication among specializations in scientific psychology, the speakers were asked to survey their research area and present their own work in a way that would be accessible to their colleagues in other areas. Another purpose of the meeting was to bring researchers together from different parts of the world, reflecting their different approaches to the scientific study of mind, brain, and behavior. Consequently, the eminent researchers who have written the twenty-six chapters included in the present volume were drawn from universities and research institutes in North America, Europe, Japan, Russia, Israel, and New Zealand. The chapters cover a range of topics in human and animal experimental psychology. The first section deals with psychobiological processes - the interplay of body and mind in determining intelligence, stress, and pain. The next five chapters address current issues in neuropsychology and neuroscience, including the neural correlates of attention and vision. A third section looks at learning processes in humans and animals, and a fourth deals with a range of topics in perception and cognition. The final five chapters take a developmental perspective, presenting theoretical and empirical analyses of the acquisition of perceptual and cognitive abilities. Overall, the collection illustrates the growing trend to break down traditional barriers between areas of experimental psychology; there are many instances of profitable interactions between researchers studying aspects of behavior and those studying the biological bases of these behaviors. The twenty-six chapters give an excellent overview of current research in scientific psychology.
Author: Eugene J. Eisen Publisher: World Scientific ISBN: 1860945651 Category : Science Languages : en Pages : 378
Book Description
The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB)
Author: Susanna Pietropaolo
Author: Susanna Pietropaolo
Author: W. E. Crusio
Author: Susanna Pietropaolo
Author: Wim E. Crusio
Author: Byron C. Jones
Author: Jacqueline N. Crawley
Author: W. E. Crusio
Author: Valter Tucci
Author: Fergus Craik
Author: Eugene J. Eisen