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Author: Andreas Scherer Publisher: John Wiley & Sons ISBN: 9780470685990 Category : Science Languages : en Pages : 272
Book Description
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.
Author: Andreas Scherer Publisher: John Wiley & Sons ISBN: 9780470685990 Category : Science Languages : en Pages : 272
Book Description
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.
Author: Giovanni Parmigiani Publisher: Springer Science & Business Media ISBN: 0387216790 Category : Medical Languages : en Pages : 511
Book Description
This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.
Author: Andreas Scherer Publisher: John Wiley & Sons ISBN: 0470741384 Category : Science Languages : en Pages : 292
Book Description
Batch Effects and Noise in Microarray Experiments: Sources and Solutions looks at the issue of technical noise and batch effects in microarray studies and illustrates how to alleviate such factors whilst interpreting the relevant biological information. Each chapter focuses on sources of noise and batch effects before starting an experiment, with examples of statistical methods for detecting, measuring, and managing batch effects within and across datasets provided online. Throughout the book the importance of standardization and the value of standard operating procedures in the development of genomics biomarkers is emphasized. Key Features: A thorough introduction to Batch Effects and Noise in Microrarray Experiments. A unique compilation of review and research articles on handling of batch effects and technical and biological noise in microarray data. An extensive overview of current standardization initiatives. All datasets and methods used in the chapters, as well as colour images, are available on www.the-batch-effect-book.org, so that the data can be reproduced. An exciting compilation of state-of-the-art review chapters and latest research results, which will benefit all those involved in the planning, execution, and analysis of gene expression studies.
Author: Richard M. Simon Publisher: Springer Science & Business Media ISBN: 0387218661 Category : Medical Languages : en Pages : 205
Book Description
The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.
Author: Terry Speed Publisher: CRC Press ISBN: 0203011236 Category : Mathematics Languages : en Pages : 237
Book Description
Although less than a decade old, the field of microarray data analysis is now thriving and growing at a remarkable pace. Biologists, geneticists, and computer scientists as well as statisticians all need an accessible, systematic treatment of the techniques used for analyzing the vast amounts of data generated by large-scale gene expression studies
Author: Thomas P. Ryan Publisher: John Wiley & Sons ISBN: 0470074345 Category : Mathematics Languages : en Pages : 620
Book Description
A complete and well-balanced introduction to modern experimental design Using current research and discussion of the topic along with clear applications, Modern Experimental Design highlights the guiding role of statistical principles in experimental design construction. This text can serve as both an applied introduction as well as a concise review of the essential types of experimental designs and their applications. Topical coverage includes designs containing one or multiple factors, designs with at least one blocking factor, split-unit designs and their variations as well as supersaturated and Plackett-Burman designs. In addition, the text contains extensive treatment of: Conditional effects analysis as a proposed general method of analysis Multiresponse optimization Space-filling designs, including Latin hypercube and uniform designs Restricted regions of operability and debarred observations Analysis of Means (ANOM) used to analyze data from various types of designs The application of available software, including Design-Expert, JMP, and MINITAB This text provides thorough coverage of the topic while also introducing the reader to new approaches. Using a large number of references with detailed analyses of datasets, Modern Experimental Design works as a well-rounded learning tool for beginners as well as a valuable resource for practitioners.
Author: Robert G. Easterling Publisher: John Wiley & Sons ISBN: 1118954637 Category : Mathematics Languages : en Pages : 268
Book Description
Professionals in all areas – business; government; the physical, life, and social sciences; engineering; medicine, etc. – benefit from using statistical experimental design to better understand their worlds and then use that understanding to improve the products, processes, and programs they are responsible for. This book aims to provide the practitioners of tomorrow with a memorable, easy to read, engaging guide to statistics and experimental design. This book uses examples, drawn from a variety of established texts, and embeds them in a business or scientific context, seasoned with a dash of humor, to emphasize the issues and ideas that led to the experiment and the what-do-we-do-next? steps after the experiment. Graphical data displays are emphasized as means of discovery and communication and formulas are minimized, with a focus on interpreting the results that software produce. The role of subject-matter knowledge, and passion, is also illustrated. The examples do not require specialized knowledge, and the lessons they contain are transferrable to other contexts. Fundamentals of Statistical Experimental Design and Analysis introduces the basic elements of an experimental design, and the basic concepts underlying statistical analyses. Subsequent chapters address the following families of experimental designs: Completely Randomized designs, with single or multiple treatment factors, quantitative or qualitative Randomized Block designs Latin Square designs Split-Unit designs Repeated Measures designs Robust designs Optimal designs Written in an accessible, student-friendly style, this book is suitable for a general audience and particularly for those professionals seeking to improve and apply their understanding of experimental design.
Author: Robert Gentleman Publisher: Springer Science & Business Media ISBN: 0387293620 Category : Computers Languages : en Pages : 478
Book Description
Full four-color book. Some of the editors created the Bioconductor project and Robert Gentleman is one of the two originators of R. All methods are illustrated with publicly available data, and a major section of the book is devoted to fully worked case studies. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.
Author: Edmund R. Malinowski Publisher: John Wiley & Sons ISBN: Category : Mathematics Languages : en Pages : 280
Book Description
Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Author: Gerald van Belle Publisher: John Wiley & Sons ISBN: 0470127279 Category : Mathematics Languages : en Pages : 256
Book Description
An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.
Author: Andreas Scherer
Author: Andreas Scherer
Author: Giovanni Parmigiani
Author: Andreas Scherer
Author: Richard M. Simon
Author: Terry Speed
Author: Thomas P. Ryan
Author: Robert G. Easterling
Author: Robert Gentleman
Author: Edmund R. Malinowski
Author: Gerald van Belle