Winter's Basic Clinical Pharmacokinetics PDF Download

Author: Paul Beringer
Publisher: LWW
ISBN: 9781496346421
Category : Clinical pharmacology
Languages : en
Pages : 0

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Book Description
Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help pharmacy students in clinical settings and busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among students, clinical professors, and practitioners. Part I provides a basic review of pharmacokinetic principles, with extensive explanations, graphic illustrations, and detailed algorithms. Part II explains the clinical applications of these principles to problems commonly encountered in the practice setting with specific drugs. This edition includes the latest information on the clinical use of serum drug concentrations. New case studies and examples demonstrate the application of pharmacokinetics in today's clinical practice.

Author: Larry Bauer
Publisher: McGraw-Hill Medical
ISBN:
Category : Medical
Languages : en
Pages : 502

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Book Description
Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.

Author: David B. Jack
Publisher: Springer
ISBN: 1349224952
Category : Medical
Languages : en
Pages : 160

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Book Description
This compendium of essential drug data helps when planning clinical research projects and choosing drugs with specific properties. As well as covering established drugs, data is presented on compounds about to be marketed or in the last stages of clinical development.

Author: Wolfgang A. Ritschel
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 616

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Book Description

Author: Younggil Kwon
Publisher: Springer Science & Business Media
ISBN: 0306468204
Category : Medical
Languages : en
Pages : 302

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Book Description
In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Author: John R. White
Publisher: Applied Therapeutics Incorporated
ISBN:
Category : Medical
Languages : en
Pages : 256

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Book Description
Designed as a portable companion to Michael E. Winter's classic text, Basic Clinical Pharmacokinetics Handbook is a must for busy practitioners who need a fast-access reference to the specific parameters and equations required for pharmacokinetic evaluations. Part One of the handbook provides common pharmacokinetic equations along with discussions on choosing the appropriate equation for a given situation. Basic pharmacokinetic principles, assessment of renal function, and dialysis of drugs are also discussed in detail. Part Two presents pharmacokinetic data for specific drugs, including aminoglycosides, carbamazepine, cyclic antidepressants, cyclosporine, digoxin, ethosuximide, lidocaine, lithium, methotrexate, phenobarbital, phenytoin, procainamide, primidone, quinidine, salicylates, theophylline, valproic acid, and vancomycin. Appendices contain common abbreviations and a glossary of pharmacokinetic terms.

Author: Paul Beringer
Publisher: LWW
ISBN: 9781975195243
Category :
Languages : en
Pages : 0

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Book Description

Author: John E. Murphy
Publisher:
ISBN: 9781585285365
Category : Pharmacokinetics
Languages : en
Pages : 0

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Book Description
In the evolving practice of pharmacokinetics (PK), it is important to keep on top of the latest advances. John E. Murphy, a well-known leader in the field of clinical pharmacokinetics, has updated and expanded his widely-used textbook and reference. Clinical Pharmacokinetics, Sixth Edition includes the most current information, covering issues such as rational use of drug concentration measurements, changes in dosing obese patients, and considerations for a wider variety of drugs for special populations. There is also a new chapter focused on pharmacogenomics and its impact on pharmacokinetic parameters, as well as discussion of pharmacogenomics throughout the book. The new edition includes everything you need to know about pharmacokinetics today: Drugs, dosing, and therapeutic. Drug concentration measurements. New chapter on the impact of pharmacogenomics. Neonatal, pediatric, obese, and geriatric dosing. Dosing in renal disease and creatinine clearance estimation. Drugs sorted by family and as single drugs. Written in a straightforward style, with numerous charts and lists, the sixth edition makes complicated dosing and monitoring information easy to find and understand. Whether you are a student or practitioner, it is a resource you will turn to for reliable guidance throughout your pharmacy career.

Author: Soraya Dhillon
Publisher: Pharmaceutical Press
ISBN: 9780853695714
Category : Chemotherapy
Languages : en
Pages : 284

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Book Description
Pharmacokinetics is the study of the process of drug absorption, distribution, metabolism and elimination. The aim of applying pharmacokinetic principles is to individualise the dose of drug, and optimise the outcome achieved in each patient. Its application reduces the chance of under-treatment, inadvertent poisoning, and dose related adverse effects. This new edition is specifically aimed at supporting undergraduate studies in pharmacokinetics, and has a strong emphasis on the application of pharmacokinetics in routine clinical practice. Clinical Pharmacokinetics also includes several case studies and 'questions and answers' to further aid understanding and revision.

Author: Mohsen A. Hedaya
Publisher: CRC Press
ISBN: 1439850739
Category : Medical
Languages : en
Pages : 599

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Book Description
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.