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Author: Achim Stolle Publisher: Royal Society of Chemistry ISBN: 1782621989 Category : Science Languages : en Pages : 321
Book Description
Ball milling has emerged as a powerful tool over the past few years for effecting chemical reactions by mechanical energy. Allowing a variety of reactions to occur at ambient temperatures and in solvent-free conditions, ball milling presents a greener route for many chemical processes. Compared to the use of microwave and ultrasound as energy sources for chemical reactions, ball milling is not as familiar to chemists and yet it holds great potential. This book will introduce practicing chemists to the technique and will highlight its importance for green transformations. Current applications of ball milling will be covered in detail as well as its origin, recent developments and future scope, challenges and prospects. Chemical transformations covered include carbon-carbon and carbon-heteroatom bond formation, oxidation by solid oxidants, asymmetric organo-catalytic reactions, dehydrogenative coupling, peptide syntheses and polymeric material syntheses. The book will provide a valuable guide for organic, inorganic and organometallic chemists, material scientists, polymer scientists, reaction engineers and postgraduate students in chemistry.
Author: Achim Stolle Publisher: Royal Society of Chemistry ISBN: 1782621989 Category : Science Languages : en Pages : 321
Book Description
Ball milling has emerged as a powerful tool over the past few years for effecting chemical reactions by mechanical energy. Allowing a variety of reactions to occur at ambient temperatures and in solvent-free conditions, ball milling presents a greener route for many chemical processes. Compared to the use of microwave and ultrasound as energy sources for chemical reactions, ball milling is not as familiar to chemists and yet it holds great potential. This book will introduce practicing chemists to the technique and will highlight its importance for green transformations. Current applications of ball milling will be covered in detail as well as its origin, recent developments and future scope, challenges and prospects. Chemical transformations covered include carbon-carbon and carbon-heteroatom bond formation, oxidation by solid oxidants, asymmetric organo-catalytic reactions, dehydrogenative coupling, peptide syntheses and polymeric material syntheses. The book will provide a valuable guide for organic, inorganic and organometallic chemists, material scientists, polymer scientists, reaction engineers and postgraduate students in chemistry.
Author: William C. Shearouse Publisher: ISBN: Category : Languages : en Pages : 175
Book Description
As environmental regulations become more stringent, the industrial chemical community needs methods that are sustainable, yet parallel the modern advances of organic synthesis. We believe we are solving the solution to this global problem through the development of sustainable synthesis that utilizes ball milling. Ball milling, unlike traditional synthetic methods, uses mechanical energy to drive organic reactions and transformations towards completion. Not only are we interested in finding reaction pathways that produce desired organic products in high yields, but also we are interested in understanding the mechanisms and theory of these processes in hopes that we may develop chemistries that have synthetic outcomes that are not attainable under traditional synthetic techniques. As a group, we each target different areas of "known" organic synthesis, in order to develop parallel routes that utilize sustainable, ball milling practices. Ball milling and green chemistry are introduced and described in Chapter 1. This dissertation describes specifically my efforts towards the aforementioned goals. Largely, my efforts focused on the development of sustainable olefination reactions, namely, the Wittig reaction and Horner-Wadsworth-Emmons reactions described in Chapters 3 and 4 respectively. In addition, portions of my dissertation research sought to expand the capability of ball milling reactions through the engineering and development of new ball milling tools. The use of functional resins as purification tools for ball milling reactions, described in Chapter 5, as well as the design and fabrication of vials made from different materials, described in Chapter 2, complete my dissertation research.
Author: Davor Margetic Publisher: Elsevier ISBN: 0128025255 Category : Science Languages : en Pages : 388
Book Description
Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions Integrates advances in green chemistry research into industrial applications and process development Focuses on designing techniques in organic synthesis directed toward mild reaction conditions Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds
Author: Bimal K. Banik Publisher: Elsevier ISBN: 0128175923 Category : Medical Languages : en Pages : 1044
Book Description
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis
Author: Bimal Krishna Banik Publisher: Elsevier ISBN: 0443161658 Category : Science Languages : en Pages : 658
Book Description
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials. Highlights the need for the adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these factors Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Author: Angelo Albini Publisher: Springer ISBN: 3319258958 Category : Science Languages : en Pages : 112
Book Description
This brief discusses the formation of modern “green chemistry” as a contribution to sustainability and the historic paths that lead to the key concepts of this discipline. Within this intellectual framework, the book tackles the 12 principles of green chemistry and the 12 principles of green chemical engineering as well as related financial and management issues; these facts are explored and reformulated in a focused set of paradigms. The best choice of a model for quantitative assessment (sufficiently specific to account for the many parameters involved but not excessively detailed to inhibit practical use) is discussed and examples of practical applications are presented.
Author: Goutam Brahmachari Publisher: Elsevier ISBN: 0323851304 Category : Science Languages : en Pages : 646
Book Description
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability
Author: Daniel C. Waddell Publisher: ISBN: Category : Languages : en Pages : 261
Book Description
Recently, there has been a focused effort towards the development of an environmentallyfriendly America. The field of green chemistry has been born of this ideology. Green chemistryis the reduction or elimination of environmentally hazardous chemicals and chemical processes. The Mack lab attempts to reduce some of these hazards by synthesizing molecules with a solventfree and environmentally benign method known as high speed ball milling (HSBM). In HSBM, reactants are shaken vigorously in a reaction vial and the subsequent mixing and impactsgenerated deliver enough energy to the system to facilitate a chemical reaction. Here, we presentthe succesful incorporation of HSBM into organic synthesis. Acid/base chemistry, the Tischenkoreaction, and enolate chemistry will be described in detail. As we increase our knowledge aboutthe solvent free method of HSBM, we are creating a unique and environmentally friendlytoolbox for organic chemists which will cause a paradigm shift in the way we conduct organicreactions.
Author: Simona A Bălan Publisher: Royal Society of Chemistry ISBN: 1837671427 Category : Science Languages : en Pages : 191
Book Description
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are extensively used in consumer products, despite their high persistence and other hazards. The risks posed by this chemical class to human health and the environment, which are increasingly becoming understood, have triggered regulation and policy changes. However, safer alternatives to these technically effective materials and methods to discover and use those alternatives are still under development. Remediation of PFAS contaminated sites will not solve the growing worldwide pollution, but substitution with safer substances at the formulation and manufacturing phases will at least abate the flow of PFASs into our bodies and environment. Introducing safer alternatives to some of the PFASs of concern used in select industry sectors, this book informs the reader about the processes of chemical hazard and alternatives assessment that can foster innovation. It is a valuable resource for both green chemists and industrial chemists interested in how they can make their products safer without compromising on function.
Author: Achim Stolle
Author: Achim Stolle
Author: William C. Shearouse
Author: Davor Margetic
Author: Bimal K. Banik
Author: Bimal Krishna Banik
Author: Angelo Albini
Author: Goutam Brahmachari
Author: Zengshe Liu
Author: Daniel C. Waddell
Author: Simona A Bălan