Bacterial vaccines in clinical and preclinical development 2021 PDF Download

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240052453
Category : Medical
Languages : en
Pages : 92

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Author: World Health Organization
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: World Health Organization
Publisher: World Health Organization
ISBN: 924009346X
Category : Medical
Languages : en
Pages : 72

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Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240093982
Category : Medical
Languages : en
Pages : 42

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This ECVP is a new technical product that aims to anticipate and collectively delineate the clinical trial, observational and other data likely to be required by global and national policy-makers, and to do so when most valuable – during development of the late-stage clinical plan, including the design of the pivotal licensure trial. Proactively generating this evidence as part of or in parallel to clinical development – where feasible – rather than reactively post-licensure, creates an opportunity to accelerate vaccine policy formulation, adoption and impact, particularly in LMICs.

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240047654
Category : Business & Economics
Languages : en
Pages : 104

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Author: World Health Organization
Publisher: World Health Organization
ISBN: 924007466X
Category : Medical
Languages : en
Pages : 197

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Author: National Academies Of Sciences Engineeri
Publisher: National Academies Press
ISBN: 9780309269452
Category : Medical
Languages : en
Pages :

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The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.

Author: Hiroshi Kiyono
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 528

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This comprehensive, authoritative treatise covers all facets of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which with basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Key Features Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization

Author:
Publisher: World Health Organization
ISBN: 9240021302
Category : Business & Economics
Languages : en
Pages : 76

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This report is the World Health Organization’s (WHO) fourth annual review of the clinical antibacterial pipeline, and the second review of the preclinical antibacterial pipeline. The WHO’s annual antibacterial pipeline report reviews antibiotics that are in the clinical stages of development as well as those in early development to assess the progress and gaps in relation to urgent threat of drug-resistance.The report evaluates the potential of these antibacterial candidates in development to address the most threatening drug-resistant bacteria as outlined in the WHO Bacterial Priority Pathogens List (WHO PPL). This report covers direct-acting small molecules and biological agents that are in development worldwide. In this fourth edition, the report includes for the first time a comprehensive overview of non-traditional antibacterial medicines. This report is part of the WHO’s efforts in global research and development (R&D) priority setting to contain antimicrobial resistance. All the data contained in this report can be downloaded from the WHO Global Observatory on Health R&D.

Author: P.J. Sansonetti
Publisher: Springer Science & Business Media
ISBN: 3642772382
Category : Medical
Languages : en
Pages : 151

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Book Description
Shigellosis is present all over the world. Anyone traveling in developing countries knows that the control of this invasive disease of the intestine is a priority task for physicians and public health authorities. Victims are essentially young children, and complications such as the hemolytic uremic syndrome make shigellosis a systemic disease rather than simply an infection of the colonic mucosa. However, "Westerners" should not consider shigeJlosis as an unlikely threat of the tropics. The disease arises in industrialized countries as soon as breaches in sanitation appear. A few months ago, at least 500 people developed shigellosis in northern France in an outbreak of Shigella sonnei infection due to accidental contamination of an urban water delivery system. The pathogenesis of shigellosis is an extraordinary topic of research because study of the invasion of the colonic mucosa addresses fundamental questions on. the molecular and cellular mechanisms by which a bacterial pathogen can pene trate non phagocytic cells, survive, multiply, spread in the intra cellular compartment, and eventually kill host cells. Further development of the infection within subepithelial tissues as well as the mechanisms that contribute to the eradication of this process have barely been studied.