Automation of Cytogenetics PDF Download

Author: Mortimer Mendelsohn
Publisher:
ISBN:
Category : Cytogenetics
Languages : en
Pages : 204

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Author: Claes Lundsteen
Publisher:
ISBN:
Category : Automation
Languages : en
Pages : 340

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Author: Steven L. Gersen
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 580

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Book Description
Enlightening and accessible, The Principles of Clinical Cytogenetics constitutes an indispensable reference for today's physicians who depend on the cytogenetics laboratory for the diagnosis of their patients.

Author: Steven L. Gersen
Publisher: Springer Science & Business Media
ISBN: 1592598331
Category : Medical
Languages : en
Pages : 589

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Book Description
In the summer of 1989, one of us (SLG), along with his mentor, Dorothy Warb- ton, attended the Tenth International Workshop on Human Gene Mapping. The me- ing was held at Yale University in celebration of the first such event, which also took place there. This meeting was not open to the general public; one had to have contributed to mapping a gene to be permitted to attend. The posters, of course, were therefore all related to gene mapping, and many were covered with pretty, colorful pictures of a novel, fluorescent application of an old technology, in situ hybridization. Walking through the room, Dorothy remarked that, because of this new FISH technique, ch- mosomes, which had become yesterday’s news, were once again “back in style. ” Approximately three years later, a commercial genetics company launched a FISH assay for prenatal ploidy detection. A substantial number of cytogeneticists across the country reacted with a combination of outrage and panic. Many were concerned that physicians would be quick to adopt this newfangled upstart test and put us all on the unemployment line. They did not at the time realize what Dorothy instinctively already knew—that FISH would not spell the doom of the cytogenetics laboratory, but it would, rather, take it to new heights.

Author: Marilyn S. Arsham
Publisher: John Wiley & Sons
ISBN: 1119061229
Category : Science
Languages : en
Pages : 1216

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Book Description
Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic sequence under investigation. The AGT Cytogenetics Laboratory Manual, Fourth Edition offers a comprehensive description of the diagnostic tests offered by the clinical laboratory and explains the science behind them. One of the most valuable assets is its rich compilation of laboratory-tested protocols currently being used in leading laboratories, along with practical advice for nearly every area of interest to cytogeneticists. In addition to covering essential topics that have been the backbone of cytogenetics for over 60 years, such as the basic components of a cell, use of a microscope, human tissue processing for cytogenetic analysis (prenatal, constitutional, and neoplastic), laboratory safety, and the mechanisms behind chromosome rearrangement and aneuploidy, this edition introduces new and expanded chapters by experts in the field. Some of these new topics include a unique collection of chromosome heteromorphisms; clinical examples of genomic imprinting; an example-driven overview of chromosomal microarray; mathematics specifically geared for the cytogeneticist; usage of ISCN’s cytogenetic language to describe chromosome changes; tips for laboratory management; examples of laboratory information systems; a collection of internet and library resources; and a special chapter on animal chromosomes for the research and zoo cytogeneticist. The range of topics is thus broad yet comprehensive, offering the student a resource that teaches the procedures performed in the cytogenetics laboratory environment, and the laboratory professional with a peer-reviewed reference that explores the basis of each of these procedures. This makes it a useful resource for researchers, clinicians, and lab professionals, as well as students in a university or medical school setting.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 640

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Author: Joannes Eleutherius Wilhelmus Beneken
Publisher: IOS Press
ISBN: 9789051991192
Category : Medical
Languages : en
Pages : 380

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Book Description
Title Page -- CONTENTS -- PREFACE -- ASSESSMENT OF THE DIAGNOSTIC PERFORMANCE OF ECG COMPUTER PROGRAMS -- OBJECTIVE MEDICAL DECISION-MAKING: CLINICAL DATABASE FOR DIAGNOSIS OF JAUNDICE (EURICTERUS) -- OBJECTIVE MEDICAL DECISION MAKINGACUTE ABDOMINAL PAIN -- PROGNOSTIC VALUE OF AMBULATORY BLOOD PRESSURE -- CHEMICAL SENSORS FOR IN VIVO MONITORING -- OCULAR FLUOROMETRY: STANDARDIZATION AND INSTRUMENTATION DEVELOPMENT -- QUANTITATIVE ASSESSMENT OF OSTEOPOROSIS -- PET INVESTIGATION OF CELLULAR REGENERATION AND DEGENERATION -- ELECTRICAL IMPEDANCE TOMOGRAPHY APPLIED POTENTIAL TOMOGRAPHY -- AUTOMATION OF CYTOGENETICS -- BIOMAGNETISM: A DIAGNOSTIC TOOL -- NEW TECHNOLOGIES FOR COMMUNICATION IN THE HEARING IMPAIRED -- REPLACEMENT OF BODY PARTS AND FUNCTIONS BIOMATERIALS RESEARCH - HAEMOCOMPATIBILITY - -- TECHNOLOGY AND BLINDNESS -- DEVELOPMENT AND OPTIMIZATION OF HYPERTHERMIA TECHNOLOGIES IN CANCER TREATMENT -- SKELETAL IMPLANTS -- THE EVALUATION OF THE EFFICACY OF TECHNOLOGY IN THE ASSESSMENT AND REHABILITATION OF BRAIN-DAMAGED PATIENTS -- COMPARATIVE EVALUATION OF MEDICAL EQUIPMENT (CEME) -- TISSUE CHARACTERIZATION BY MAGNETIC RESONANCE SPECTROSCOPY (MRS) AND IMAGING (MRI) -- MOBILITY RESTORATION FOR PARALYSED PERSONS -- MONITORING OF FRACTURE HEALING -- THE EC BIOMEDICAL AND HEALTH RESEARCH PROGRAMME (BIOMED) 1991-1994 -- EC MEDICAL AND HEALTH RESEARCH PROGRAMME 1987 - 1991

Author: John R. Gosden
Publisher: Springer Science & Business Media
ISBN: 1592595162
Category : Medical
Languages : en
Pages : 508

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Book Description
Chromosomes, as the genetic vehicles, provide the basic material for a large proportion of genetic investigations, from the construction of gene maps and models of chromosome organization, to the inves tigation of gene function and dysfunction. The study of chromosomes has developed in parallel with other aspects of molecular genetics, beginning with the first preparations of chromosomes from animal cells, through the development of banding techniques, which permitted the unequivocal identification of each chromosome in a karyotype, to the present analytical methods of molecular cytogenetics. Although some of these techniques have been in use for many years, and can be learned relatively easily, most published scientific reports—as a result of pressure on space from editors, and the response to that pressure by authors—contain little in the way of technical detail, and thus are rarely adequate for a researcher hoping to find all the necessary information to embark on a method from scratch. A new user needs not only a detailed description of the methods, but also some help with problem solving and sorting out the difficulties en countered in handling any biological system. This was the require ment to which the series Methods in Molecular Biology is addressed, and Chromosome Analysis Protocols forms a part of this series.

Author: Günter Obe
Publisher: Springer Science & Business Media
ISBN: 3642755992
Category : Science
Languages : en
Pages : 333

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Book Description
The new field of applied genetic research, genetic toxicology and mutation research investigates the muta- genicity and cancerogenicity of chemicals and other agents. Permanent changes in genes and chromosomes, or genome mutations, can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses. Mutagenesis research has two aims: (1) to understand the molecular mechanisms leading to mutations, and (2) to prevent a thoughtless introduction of mutagenic agents into our environment. Both aspects, namely, basic and applied, will be treated in the new series Advances in Mutagenesis Research.

Author: Padma Tirunilai
Publisher: BoD – Books on Demand
ISBN: 9535101781
Category : Medical
Languages : en
Pages : 160

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Book Description
Recent Trends in Cytogenetic Studies - Methodologies and Applications deals with recent trends in cytogenetics with minute details of methodologies that can be adopted in clinical laboratories. The chapters deal with basic methods of primary cultures, cell lines and their applications; microtechnologies and automations; array CGH for the diagnosis of fetal conditions; approaches to acute lymphoblastic and myeloblastic leukemias in patients and survivors of atomic bomb exposure; use of digital image technology and using chromosomes as tools to discover biodiversity. While concentrating on the advanced methodologies in cytogenetic studies and their applications, authors have pointed out the need to develop cytogenetic labs with modern tools to facilitate precise and effective diagnosis to benefit the patient population.