Author: M M. C
Publisher:
ISBN:
Category :
Languages : en
Pages : 200
Book Description
Arthur Venning, by M.M.C.
Arthur Venning
Author: M. C. M. M. C.
Publisher: Kessinger Publishing
ISBN: 9781104036416
Category : Literary Collections
Languages : en
Pages : 196
Book Description
This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.
Publisher: Kessinger Publishing
ISBN: 9781104036416
Category : Literary Collections
Languages : en
Pages : 196
Book Description
This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.
Arthur Venning
Author: M. M. C.
Publisher:
ISBN:
Category : Plymouth (England)
Languages : en
Pages : 192
Book Description
Publisher:
ISBN:
Category : Plymouth (England)
Languages : en
Pages : 192
Book Description
The Western Antiquary
Author: William Henry Kearley Wright
Publisher:
ISBN:
Category : Cornwall (England : County)
Languages : en
Pages : 390
Book Description
"Reprinted after revision and correction from the 'Weekly Mercury, '" Mar. 1881-May 1884.
Publisher:
ISBN:
Category : Cornwall (England : County)
Languages : en
Pages : 390
Book Description
"Reprinted after revision and correction from the 'Weekly Mercury, '" Mar. 1881-May 1884.
The Western Antiquary; Or, Devon and Cornwall Note-book
Author:
Publisher:
ISBN:
Category : Cornwall (England : County)
Languages : en
Pages : 446
Book Description
Publisher:
ISBN:
Category : Cornwall (England : County)
Languages : en
Pages : 446
Book Description
The Devon Union List (DUL)
Author: Allan Brockett
Publisher:
ISBN:
Category : Reference
Languages : en
Pages : 586
Book Description
Publisher:
ISBN:
Category : Reference
Languages : en
Pages : 586
Book Description
Cystogenesis
Author: Jong Hoon Park
Publisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128
Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Publisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128
Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
The Zinc Corporation ...
Author: Everett Price Hurt
Publisher:
ISBN:
Category : Broken Hill Mines (N.S.W.)
Languages : en
Pages : 168
Book Description
Publisher:
ISBN:
Category : Broken Hill Mines (N.S.W.)
Languages : en
Pages : 168
Book Description
Report of Trustees
Author: Medford, Mass. Public Library
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
Book Description
Recommendations of the Commission
Author: India. Calcutta University Commission
Publisher:
ISBN:
Category : Education
Languages : en
Pages : 506
Book Description
Publisher:
ISBN:
Category : Education
Languages : en
Pages : 506
Book Description