Author: Alexander G. Bearn Publisher: Oxford University Press, USA ISBN: Category : Biography & Autobiography Languages : en Pages : 258
Book Description
In this scholarly and insightful biography, Alexander G. Bearn, a physician and a scientist in the Garrodian tradition, has drawn a portrait of one of the great minds of twentieth century medicine. It is story of intellectual achievement. But the book also gives a fascinating account of the life of a talented professional family and a perspective on the practice of medicine and on medical education at the turn of the century. Archibald Garrod is chiefly remembered as the originator of the concept of inborn metabolic error, an idea which grew from his studies of families with diseases whose biochemical basis he was able to identify. He was widely recognized for this achievement in his own lifetime and held a respected position in the medical establishment, a position accorded to him on the basis of his scientific achievement rather than for any great clinical skill. But to concentrate on the concept of inborn errors is to overlook what has in time turned out to be Garrod's greatest achievement, for it was he who first saw that genetics, biochemistry, and medicine are fundamentally linked. He propounded, to all who would listen, his thesis that disease can only be properly studied in the light of an individual's genetic susceptibility, and that that in turn rests on biochemical individuality. Only by thinking of human diseases as the consequences of genetic and environmental interaction are the advances of today's and tomorrow's medicine possible.
Author: Alexander G Bearn Publisher: American Philosophical Society Press ISBN: 9781422380048 Category : Languages : en Pages : 0
Book Description
Students of biology learn that Archibald Garrod (1857-1936) advanced the concept of inborn errors of metabolism through brilliant insights into patients with rare genetic diseases. Garrod's two other prescient concepts are often overlooked: (1) the concept of the chemical uniqueness of the individual, which prefigured the modern appreciation of individual predisposition to disease; & (2) the concept of the physician-scientist, which prefigured the modern revolution in biomedical research. All three concepts are brought into sharp focus in this incisive biography, written devotedly by Alexander G. Bearn, a disciple whose own career is based firmly on the Garrodian tradition. Illustrations.
Author: Barton Childs Publisher: JHU Press ISBN: 142140513X Category : Medical Languages : en Pages : 345
Book Description
In Genetic Medicine: A Logic of Disease, Barton Childs demonstrates that knowledge of the ways both genes and environment contribute to disease provides a rational basis for medical thinking. This "genetic" medicine, he explains, should help the physician use the results of laboratory tests to perceive the uniqueness of the patient as well as that of the family and the cultural conditions in which the patient's condition arose. Childs thus provides a conceptual framework within which to teach and practice a humane medicine.
Author: Nathaniel Comfort Publisher: Yale University Press ISBN: 0300188870 Category : Science Languages : en Pages : 371
Book Description
Almost daily we hear news stories, advertisements, and scientific reports that promise genetic medicine will make us live longer, enable doctors to identify and treat diseases before they start, and individualize our medical care. But surprisingly, a century ago eugenicists were making the same promises. The Science of Human Perfection traces the history of the promises of medical genetics and of the medical dimension of eugenics. The book also considers social and ethical issues that cast troublesome shadows over these fields./divDIV DIVKeeping his focus on America, science historian Nathaniel Comfort introduces the community of scientists, physicians, and public health workers who have contributed to the development of medical genetics from the nineteenth century to today. He argues that medical genetics is closely related to eugenics, and indeed the two cannot be fully understood separately. He also carefully examines how the desire to relieve suffering and to improve ourselves genetically, though noble, may be subverted. History makes clear that as patients and consumers we must take ownership of genetic medicine, using it intelligently, knowledgeably, and skeptically, lest pernicious interests trump our own./div
Author: Nicholas Wright Gillham Publisher: FT Press ISBN: 0132623242 Category : Medical Languages : en Pages : 353
Book Description
This very readable overview of the rise and transformations of medical genetics and of the eugenic impulses that have been inspired by the emerging understanding of the genetic basis of many diseases and disabilities is based on a popular nonmajors course, "Social Implications of Genetics," that Gillham gave for many years at Duke University. The book is suitable for use as a text in similar overview courses about genes and social issues or genes and disease. It gives a good overview of the developments and status of this field for a wide range of biomedical researchers, physicians, and students, especially those interested in the prospects for the new, genetics-based personalized medicine.
Author: Jan Sapp Publisher: Oxford : Oxford University Press ISBN: 9780195156195 Category : Science Languages : en Pages : 388
Book Description
What is evolution? What is a gene? How did these concepts originate and how did they develop? This book is a short history ranging from Lamarck and Darwin to DNA and the Human Genome Project, exploring the conceptual oppositions, techniques, institutional conditions and controversies that have shaped the development of biology.
Author: Eberhard Passarge Publisher: Thieme ISBN: 1604061383 Category : Medical Languages : en Pages : 500
Book Description
A remarkable achievement by a single author...concise but informative...No geneticist or physician interested in genetic diseases should be without a copy of this remarkable edition. --American Journal of Medical GeneticsMore than ever, a solid understanding of genetics is a fundamental element of all medical and scientific educational programs, across virtually all disciplines. And the applications--and implications--of genetic research are at the heart of current medical scientific debates. Completely updated and revised, The Color Atlas of Genetics is an invaluable guide for students of medicine and biology, clinicians, and anyone else interested in this rapidly evolving field. The latest edition of this highly praised atlas retains several popular features, such as the accessible layout and logical structure, in addition to many novel features and 20 completely new color plates on new topics, including: Cell-to-cell communication, including important signaling and metabolic pathways Taxonomy of living organisms (tree of life) Epigenetic modifications in chromatin Apoptosis RNA interference (RNAi) Comparative genomic hybridization Origins of cancer Principles of gene and stem cell therapy, etc. With more than 200 absorbing full-color plates concisely explained on facing pages, the atlas offers readers an easy-to-use, yet remarkably detailed guide to key molecular, theoretical, and medical aspects of genetics and genomics. Brief descriptions of numerous genetic diseases are included, with references for more detailed information.Readers will find that this incomparable book presents a comprehensive picture of the field from its fascinating history to its most advanced applications.
Author: Ruth Schwartz COWAN Publisher: Harvard University Press ISBN: 0674029925 Category : Medical Languages : en Pages : 303
Book Description
Neither minimizing the difficulty of the choices that modern genetics has created for us nor fearing them, Cowan argues that we can improve the quality of our own lives and the lives of our children by using the modern science and technology of genetic screening responsibly.
Author: Roy Porter Publisher: Yale University Press ISBN: 9780300082746 Category : Medical Languages : en Pages : 414
Book Description
Gout has been seen as a disease afflicting upper-class males of superior wit, genius and creativity. It is also believed to protect its sufferers and assure long life. This study investigates the history of gout and offers a perspective on medical and social history, sex, prejudice and class.
Author: Alexander G. Bearn
Author: Alexander G Bearn
Author: Barton Childs
Author: Nathaniel Comfort
Author: Nicholas Wright Gillham
Author: Jan Sapp
Author: Mikulas Teich
Author: Eberhard Passarge
Author: Ruth Schwartz COWAN
Author: Roy Porter