Author: Kenneth W. BlairPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 364
Book Description
Approaches to the Total Synthesis of Lycorine
Author: Kenneth W. BlairPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 364
Book Description
Total synthesis of racemic acorone and synthetic approaches to erythramine and lycorine
Author: Ta-shue ChouPublisher:
ISBN:
Category : Terpenes
Languages : en
Pages : 282
Book Description
Intramolecular [4 + 2] cycloaddition reactions of enamides
![Intramolecular [4 + 2] cycloaddition reactions of enamides PDF](https://books.google.com/books/content/images/frontcover/211NtwAACAAJ?fife=w80-h100)
Author: Chih-yun Johnny TuPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 294
Book Description
Efforts Towards the Total Synthesis of Natural Product Alkaloids (+-) Lycorine and Gracilamine, Gold-catalyzed Diene Formation, and Oxy-CcopeeneClaisenDiels-Alder Reactions to Form the Homo-steroid Skeleton
Author: Anik Michelle ChartrandPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
The amaryllidaceae family is an attractive source of alkaloids, which are valuable targets for total synthesis. This thesis describes the ingenious approach to the synthesis of two amaryllidaceae alkoids: (+/-)-lycorine and gracilamine. Utilization of the phenylbutadiene and pyrroline intramolecular push-pull Diels-Alder reaction for lycorine and of the intramolecular 1,3-dipolar cycloaddition for gracilamine is described. A route was developed to give access to advanced intermediates required for both syntheses. However the existing methodology did not fully accommodate the complete core structure of the targets. Development of a new novel gold-catalyzed reaction is also depicted. A facile and quick method to generate dienes from propargylic acetates and pyvaloates has been developed. The scopes and limitations of this methodology are discussed. The application of the newly discovered Au(PPh3)Cl and acid catalyst system was examined. Finally, we investigated the 1-alkynyl-2-vinyl-cyclohexanols for the formation of multi-cyclic skeletons found in natural products. Our goal was to develop a way to easily access the steroid and/or carbocyclic core in one tandem reaction sequence. To this end, the use of a tandem oxy-cope/Claisen/ene/Diels-Alder reaction was developed. The tandem oxy-Cope/Claisen/ene/Diels-Alder reaction can produce up to 9 contiguous stereogenic centers where two are quaternary. In addition, this domino process provides the steroid core possessing much exploitable functionality.
Approaches to the Total Synthesis of the Lamellarins and Related Natural Products
Author: Yanan ZhangPublisher:
ISBN: 9780542192142
Category : Alkaloids
Languages : en
Pages : 364
Book Description
Approaches to the Total Synthesis of Laurenyne
Author: Rebecca P. FreemanAn Approach to the Total Synthesis of (+)-lythranidine and a Study of the Addition of Nitrones to Indoles
Author: Hsiang-Ching KungBibliography of Mass Spectroscopy Literature for 1970
Author: Total Synthesis of (±)-Maoecrystal V
Author: Jianxian GongPublisher: Springer
ISBN: 3642543049
Category : Science
Languages : en
Pages : 146
Book Description
In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Alkaloid Synthesis
Author: Hans-Joachim KnoelkerPublisher: Springer Science & Business Media
ISBN: 3642255280
Category : Science
Languages : en
Pages : 268
Book Description
Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-