Author: Thomas Tod HudecPublisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 222
Book Description
Approaches to the Synthesis of Lycorine-type Alkaloids
Author: Thomas Tod HudecPublisher:
ISBN:
Category : Organic compounds
Languages : en
Pages : 222
Book Description
Approaches to the Synthesis of Lycorine
Author: David Jacob LevyPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 122
Book Description
Approaches to the Total Synthesis of Lycorine
Author: Kenneth W. BlairPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 364
Book Description
Approaches to the Synthesis of Amaryllidaceae Alkaloids
Author: David Robert DaltonPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 382
Book Description
Approaches to the Synthesis of Aporphine and Cularine Type Alkaloids
Author: Joseph A. MerkertPublisher:
ISBN:
Category : Aporphine
Languages : en
Pages : 86
Book Description
Efforts Towards the Total Synthesis of Natural Product Alkaloids (+-) Lycorine and Gracilamine, Gold-catalyzed Diene Formation, and Oxy-CcopeeneClaisenDiels-Alder Reactions to Form the Homo-steroid Skeleton
Author: Anik Michelle ChartrandPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
The amaryllidaceae family is an attractive source of alkaloids, which are valuable targets for total synthesis. This thesis describes the ingenious approach to the synthesis of two amaryllidaceae alkoids: (+/-)-lycorine and gracilamine. Utilization of the phenylbutadiene and pyrroline intramolecular push-pull Diels-Alder reaction for lycorine and of the intramolecular 1,3-dipolar cycloaddition for gracilamine is described. A route was developed to give access to advanced intermediates required for both syntheses. However the existing methodology did not fully accommodate the complete core structure of the targets. Development of a new novel gold-catalyzed reaction is also depicted. A facile and quick method to generate dienes from propargylic acetates and pyvaloates has been developed. The scopes and limitations of this methodology are discussed. The application of the newly discovered Au(PPh3)Cl and acid catalyst system was examined. Finally, we investigated the 1-alkynyl-2-vinyl-cyclohexanols for the formation of multi-cyclic skeletons found in natural products. Our goal was to develop a way to easily access the steroid and/or carbocyclic core in one tandem reaction sequence. To this end, the use of a tandem oxy-cope/Claisen/ene/Diels-Alder reaction was developed. The tandem oxy-Cope/Claisen/ene/Diels-Alder reaction can produce up to 9 contiguous stereogenic centers where two are quaternary. In addition, this domino process provides the steroid core possessing much exploitable functionality.
Total Synthesis of the Lycorenine-type Amaryllidaceae Alkaloid (")-clivonine Via a Biomimetic Ring-switch from a Lycorine-type Progenitor
Author: Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
A fully diastereoselective total synthesis of the lycorenine-type Amaryllidaceae alkaloid (")-clivonine is reported via a route that employs for the first time a biomimetic ring-switch from a lycorine-type progenitor, thereby corroborating experimentally the biogenetic hypothesis first expounded for these compounds by Barton in 1960.
Approaches Towards the Synthesis of the Uleine-type Alkaloids [microform]
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Author: Eenkhoorn, Johan AdriaanPublisher: National Library of Canada
ISBN:
Category :
Languages : en
Pages :
Book Description
Approaches to the Biogenetically Patterned Synthesis of Amaryllidaceae Alkaloids
Author: Steven William ScottPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 198
Book Description
Author: