Author: Azim Jeraj ShariffPublisher:
ISBN:
Category :
Languages : en
Pages : 402
Book Description
Approaches to the Synthesis of Indole-pyridine Alkaloids
Author: Azim Jeraj ShariffNew Approaches to the Synthesis of Indole Alkaloids
Author: Loretta T. DornPublisher:
ISBN:
Category : Indole alkaloids
Languages : en
Pages : 81
Book Description
New Approaches to the Synthesis of 2-acyl Indole Alkaloids
Author: Norman Ivor James PhillipsPublisher:
ISBN:
Category : Indole alkaloids
Languages : en
Pages :
Book Description
Synthetic Methods of Indole Derivatives : Named Reactions used in the synthesis of Indole Derivatives
Author: Kuldeep SinghPublisher: Notion Press
ISBN:
Category : Education
Languages : en
Pages : 96
Book Description
Indole is the foremost heterocyclic compound in the entire heterocyclic system. Some of the ring heterocyclics are formed when the benzene ring is fused to five or six-membered heterocyclic compounds at the second and third positions of the benzene ring. It may include indole, benzofuran, quinoline, isoquinoline. Indole plays an integral role in chemical, biological and pharmacological activities. Indole nuclei carry immense importance as it built proteins in the form of amino acid tryptophan and depicts the Skelton of indole alkaloids. Indole binds with high affinity with the multiple receptors. Due to its huge medical importance such as antimicrobial, antiproliferative, antiviral, antifungal, antioxidant, antidiabetic, antihistamine, anti-inflammatory, analgesic, anticancer, antitubercular, antihypertensive, antimalarial, anticholinesterase and many more indole is found to be invariably crucial to study. The medical importance of indole amuses researchers to synthesize diverse types of indole derivatives as it also flair some new therapeutic effects. Indole moiety is a subpart of radical scavengers are found commonly in the body. Indole not only has biological importance but also acquires so many industrial applications say dyes, flavor enhancers, agriculture etc. It also has a significant role in commodity markets.
Approaches to the Synthesis of the Indole Alkaloids: Dasycarpidone, Tubifoline, Apparacine, Tabernaemontanine, and Dregamine
Author: Woodfin Vaughan LigonPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 306
Book Description
Synthesis of Indole Alkaloids
Author: Reuben Murray WhitePublisher:
ISBN:
Category : Drug development
Languages : en
Pages : 258
Book Description
A Dinitrostyrene Approach to the Synthesis of Indoles
Author: Kenneth S. HoughtonPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 190
Book Description
Approaches to the Synthesis of the Marine Alkaloid Chartellamide A: a Novel 2-(4-imidazolyl) Indole
Author: Paul Edward MurrayApproaches of the Synthesis of Apparicine
Author: Gabor I. KoletarPublisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 94
Book Description
A Unified Approach Toward the Total Syntheses of Prenylated Indole Alkaloid Natural Products
Author: Eduardo Valentin Mercado-MarinPublisher:
ISBN:
Category :
Languages : en
Pages : 356
Book Description
Abstract A Unified Approach Toward the Total Syntheses of Prenylated Indole Alkaloid Natural Products by Eduardo Valentin Mercado-Marin Doctor of Philosophy in Chemistry University of California, Berkeley Professor Richmond Sarpong, Chair This dissertation describes our approach toward a unifying synthesis of prenylated indole alkaloid natural products. Chapter 1 is an introduction and provides background to this class of natural products, focusing primarily on the isolation, biological activity, biosynthetic, and previous synthetic work of these natural products. This section also includes a discussion of synthetic approaches to the common bicyclo[2.2.2]diazaoctane core embodied in many of these natural products, which sets the stage for our entry into these molecules by a unifying route. Chapter 2 describes our entry into this class of natural products focused primarily on our synthetic and biosynthetic work toward natural products lacking the bicyclo[2.2.2]diazaoctane core. In particular, we discuss the first chemical syntheses of the prenylated indole alkaloids citrinalin B and cyclopiamine B. Along with unambiguously establishing the structures of these natural products, in collaboration with the Berlinck group, we provide evidence for the existence of a common bicyclo[2.2.2]diazaoctane containing precursor as an intermediate to natural products that lack this structural feature. Lastly, Chapter 3 describes our unified strategy for the synthesis of prenylated indole alkaloid natural products, capitalizing on our results described in Chapter 2. This unifying strategy has resulted in the syntheses of stephacidin A and 17-hydroxy-citrinalin B. Key to the success of this approach in accessing congeners containing and lacking the bicyclo[2.2.2]diazaoctane core was a complexity building isocyanate capture to forge the bicyclo[2.2.2]diazaoctane core from a common all fused precursor.