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Author: J. Andrew Williams Publisher: John Wiley & Sons ISBN: 0470170832 Category : Medical Languages : en Pages : 420
Book Description
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Author: J. Andrew Williams Publisher: John Wiley & Sons ISBN: 0470170832 Category : Medical Languages : en Pages : 420
Book Description
Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.
Author: William McGregor Publisher: Walter de Gruyter ISBN: 3110184370 Category : Language Arts & Disciplines Languages : en Pages : 445
Book Description
This collection of nine original articles deals with the expression of possession at various levels of grammar, morphological, phrasal, and syntactic, and from a typologically diverse range of languages (including Germanic, Oceanic, Meso-American, and Australian Aboriginal). There are two main aims. The first is to reveal something of the range of constructions employed cross-linguistically in the expression of possession, and second, to present an understanding of the possessive relation itself as a cognitive and linguistic phenomenon. A guiding principle in the selection of contributors has.
Author: Neil Myler Publisher: MIT Press ISBN: 0262551098 Category : Language Arts & Disciplines Languages : en Pages : 471
Book Description
A wide-ranging generative analysis of the typology of possession sentences, solving long-standing puzzles in their syntax and semantics. A major question for linguistic theory concerns how the structure of sentences relates to their meaning. There is broad agreement in the field that there is some regularity in the way that lexical semantics and syntax are related, so that thematic roles (the different participant roles in an event: agent, theme, goal, etc.) are predictably associated with particular syntactic positions. In this book, Neil Myler examines the syntax and semantics of possession sentences, which are infamous for appearing to diverge dramatically from this broadly regular pattern. On the one hand, Myler points out, possession sentences have too many meanings; in any given language, the construction used to express archetypal possessive meanings (such as personal ownership) is also often used to express other apparently unrelated notions (body parts, kinship relations, and many others). On the other hand, possession sentences have too many surface structures; languages differ markedly in the argument structures used to convey the same possessive meanings. Myler argues that recent work on the syntax-semantics interface in the generative tradition has developed the tools needed to solve these puzzles. Examining and synthesizing ideas from the literature and drawing on data from many languages (including some understudied Quechua dialects), Myler presents a novel way to understand the apparent irregularity of possession sentences while preserving explanations of general cross-linguistic regularities, offering a unified approach to the syntax and semantics of possession sentences that can also be integrated into a general theory of argument structure.
Author: Mario Bunge Publisher: Routledge ISBN: 135131307X Category : Philosophy Languages : en Pages : 481
Book Description
This collection of essays, written on four continents by scientists, philosophers and humanists, was initially presented to Karl R. Popper on his sixtieth birthday as a token of critical admiration and in recognition of his work. But the volume also stands on its own as a remarkable series of statements utilizing Popper's critical vision in the study of philosophy proper, logic, mathematics, science as method and theory, and finally to the study of society and history. What is remarkable is that Popper worked in all of these areas, not in a cursory or discursive way, but with the utmost clarity and rigor. . The core position of this volume and its contributors is that the progress of knowledge is not a linear accumulation of definitive acquisitions but a zigzagging process in which counterexamples and unfavorable evidence ruin generalizations and prompt the invention of more comprehensive and sometimes deeper generalizations, to be criticized in their turn. A critical approach to problems, procedures, and results in every field of inquiry is therefore a necessary condition for the continuance of progress. The title of this volume then is, in a sense, an homage to Popper's critical rationalism and critical empiricism. The essays are a tribute to his unceasing and uncompromising quest, not for final certainty, but for closer truth and increased clarity. Among the contributors are outstanding figures in philosophy and the exact sciences in their own right, including Herbert Feigl, R. M. Hare, J.O. Wisdom, Nicholas Rescher, David Bohm, Paul K. Feyerabend, F. A. Hayek, and Adolf Grunbaum. Social science contributions include Hans Albert on social science and moral philosophy, W. B. Gallie, on the critical philosophy of history, Pieter Geyl on The Open Society and its Enemies, and George H. Nadel on the philosophy of History.
Author: Xu Guo Publisher: Springer ISBN: 3319636707 Category : Technology & Engineering Languages : en Pages : 94
Book Description
The volume focuses on theoretical and computational approaches and involves areas such as simulation-based engineering and science, integrated computational materials engineering, mechanics, material science, manufacturing processes, and other specialized areas. Most importantly, the state-of-the-art progress in developing predictive theoretical, computational and experimental approaches for additive manufacturing is summarized.
Author: Jingyu Hou Publisher: Academic Press ISBN: 0128099445 Category : Mathematics Languages : en Pages : 126
Book Description
New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction. Provides innovative approaches and new developments targeting key issues in protein function prediction Presents heuristic ideas for further research in this challenging area
Author: Arkadiusz Paterek Publisher: Arkadiusz Paterek ISBN: Category : Mathematics Languages : en Pages : 196
Book Description
A 195-page monograph by a top-1% Netflix Prize contestant. Learn about the famous machine learning competition. Improve your machine learning skills. Learn how to build recommender systems. What's inside:introduction to predictive modeling,a comprehensive summary of the Netflix Prize, the most known machine learning competition, with a $1M prize,detailed description of a top-50 Netflix Prize solution predicting movie ratings,summary of the most important methods published - RMSE's from different papers listed and grouped in one place,detailed analysis of matrix factorizations / regularized SVD,how to interpret the factorization results - new, most informative movie genres,how to adapt the algorithms developed for the Netflix Prize to calculate good quality personalized recommendations,dealing with the cold-start: simple content-based augmentation,description of two rating-based recommender systems,commentary on everything: novel and unique insights, know-how from over 9 years of practicing and analysing predictive modeling.
Author: J. Andrew Williams
Author: J. Andrew Williams
Author: William McGregor
Author: Neil Myler
Author: Suchismita Mondal
Author: Mario Bunge
Author: Nikolaos G. Sgourakis
Author: Xu Guo
Author: Jingyu Hou
Author: Min Tang
Author: Arkadiusz Paterek