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Author: Jürg P. Seiler Publisher: Springer Science & Business Media ISBN: 3642606822 Category : Medical Languages : en Pages : 396
Book Description
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Author: Jürg P. Seiler Publisher: Springer Science & Business Media ISBN: 3642606822 Category : Medical Languages : en Pages : 396
Book Description
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Author: Philip Wexler Publisher: Academic Press ISBN: 0127447709 Category : Medical Languages : en Pages : 953
Book Description
History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
Author: K. Esser Publisher: Springer Science & Business Media ISBN: 3642572030 Category : Science Languages : en Pages : 380
Book Description
With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on genetics, cell biology, and vegetation science.
Author: A. Wallace Hayes Publisher: CRC Press ISBN: 1000875776 Category : Medical Languages : en Pages : 2143
Book Description
Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Author: Victor Kuete Publisher: Elsevier ISBN: 0128004754 Category : Medical Languages : en Pages : 742
Book Description
Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology. - Offers a critical review of the methods used in toxicological survey of medicinal plants - Provides up-to-date toxicological data on African medicinal plants and families - Serves as a resource tool for students and scientists in the various areas of toxicology
Author: DR. MUNEESH KUMAR Publisher: DARSHAN PUBLISHERS ISBN: 9386739089 Category : Science Languages : en Pages :
Book Description
This book is an introduction to applied toxicology and is designed primarily for Post graduate students and Research scholars. Now days the whole world is facing a pandemic of the most dreaded human disease caused by toxicants. Therefore study of applied toxicology serves society in many ways, not only to protect humans and the environment from the deleterious effects of toxicants but also to facilitate the development of more selective toxicants such as anticancer and other clinical drugs and pesticides. In chapters covering rapidly expanding matter, the usually required material has been presented in a fairly concise form, and then details on special aspects have been given in the form of addenda. It is hoped that this approach will meet the needs of Post graduate students, Research scholars and provide sources for more advanced study. Efforts have been made to include the latest available information in some chapters to make the book upto-date. The constructive suggestion from the conscious readers is always cordially invited for further improvement of the book. The study of toxic action from the use of biochemical and molecular techniques can be expected. No doubt new techniques will be developed, answers will be found to many questions that did not yield to earlier techniques and new questions will be raised. The challenge, as always, will be to integrate the results from these studies and reach new levels of sophistication into useful and productive approaches to reduce chemical effects on human health and the environment.
Author: A. Wallace Hayes Publisher: CRC Press ISBN: 1842145363 Category : Medical Languages : en Pages : 2186
Book Description
Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Author: National Research Council Publisher: National Academies Press ISBN: 0309112982 Category : Science Languages : en Pages : 300
Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Sandra E. Shumway Publisher: John Wiley & Sons ISBN: 1118994655 Category : Science Languages : en Pages : 696
Book Description
Harmful Algal Blooms: A Compendium Desk Reference erläutert die Grundlagen der schädlichen Algenblüte (HAB) und bietet die notwendigen technischen Informationen, wenn es um unerwartete oder unbekannte schädliche Ereignisse in Zusammenhang mit Algen geht. Dieses Fachbuch behandelt die Gründe für die schädliche Algenblüte, erfolgreiche Management- und Monitoring-Programme, Kontroll-, Präventions- und Minderungsstrategien, die wirtschaftlichen Folgen, Gesundheitsrisiken sowie die Folgen für die Nahrungskette und Ökosysteme. Darüber hinaus bietet es ausführliche Informationen zu den häufigsten HAB-Arten. Harmful Algal Blooms: A Compendium Desk Reference ist ein unschätzbares Referenzwerk für Manager, Einsteiger in das Fachgebiet, Praktiker mit eingeschränkten Zugang zu wissenschaftlicher Literatur und alle, die schnell Zugriff auf Informationen benötigen, insbesondere vor dem Hintergrund neuartiger oder unerwarteter HAB-Ereignisse. Die drei Herausgeber gehören zu den weltweit führenden Forschern auf dem Fachgebiet. Führende Experten haben ebenfalls zu diesem Fachbuch beigetragen, das sich zu einem wichtigen Referenzwerk des Fachgebiets entwickeln wird, zumal das Thema immer mehr an Bedeutung gewinnt.
Author: Jürg P. Seiler
Author: Jürg P. Seiler
Author: Bryan Ballantyne
Author: Philip Wexler
Author: K. Esser
Author: A. Wallace Hayes
Author: Victor Kuete
Author: DR. MUNEESH KUMAR
Author: A. Wallace Hayes
Author: National Research Council
Author: Sandra E. Shumway