Application of Waxes for Controlled Release of Propranolol Hydrochloride Pellets Using Hot Melt Fluidized-bed Coating Technique PDF Download

Author: Pornwipa Wattanaseri
Publisher:
ISBN: 9789745899605
Category : Drugs
Languages : en
Pages : 216

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Book Description

Author: Wanida Pornchaisuree
Publisher:
ISBN:
Category : Coating processes
Languages : en
Pages : 240

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Book Description

Author: Hong Wen
Publisher: John Wiley & Sons
ISBN: 1118060326
Category : Science
Languages : en
Pages : 571

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Book Description
This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Author: John Patrick Kennedy
Publisher:
ISBN:
Category :
Languages : en
Pages : 286

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Book Description

Author: E. Nicholas Griffin
Publisher:
ISBN:
Category :
Languages : en
Pages : 270

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Book Description

Author: Chien Ngoc Nguyen
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages : 610

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Book Description
Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating is promising, it needs modification for industrial scale-up and to provide more elegant formulations. Hot-melt capsule filling is an especially appealing and simple way to make sustained release formulations. A novel formulation of glipizide developed comprising compression of four-layer coated beads into tablets has advantages of keeping sustained-release characteristics following a lag time, providing approximately zero-order release, and releases drug nearly independent of paddle speeds 50 and 100 rpm. The amount of binding and disintegration ingredients can be adjusted to produce appropriate disintegration times for tablets and to release individually coated particulates. Formulation CH20 tablet, matched the dissolution pattern of Glucotrol-XL osmotic pump tablets in two pH media at 100 rpm paddle, and dissolution patterns of Glucotrol XL and CH20 tablet were close to each other at 50, 150 and 200 rpm paddle. This formulation is predicted by convolution simulation to be bioequivalent to Glucotrol-XL in-vivo. A novel bead formulation of verapamil was developed comprising a combination of extrusion and spheronization to produce a relatively high drug load, followed by coating with an insoluble polymer (ethylcellulose) that contains a water soluble channeling agent (lactose), thus allowing a sufficiently thick coating to be uniform and robust without "shutting down" release of the relatively insoluble drug. Formulation OSU2, provided the unexpected benefit where by adjusting the coating thickness and ethylcellulose/lactose ratio, it is possible to obtain essentially non-agitation sensitive and zero-order drug release up to 14 hours in either KCl or two different pH media at stirring speeds of either 75 or 200 rpm with the USP basket or paddle stirring method. This formulation matched the dissolution pattern of Verelan-PM capsules with basket method and paddle method in KCl medium, and two pH medium methods at different speeds and is predicted by convolution simulation to be bioequivalent to Verelan-PM in-vivo.

Author: Warapun Lekrut
Publisher:
ISBN: 9789740313809
Category :
Languages : en
Pages : 332

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Book Description

Author: Siddhi Santosh Hate
Publisher:
ISBN:
Category : Excipients
Languages : en
Pages : 48

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Book Description

Author: Ishtiaq Ahmed
Publisher: LAP Lambert Academic Publishing
ISBN: 9783846595169
Category :
Languages : en
Pages : 148

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Book Description
This book is related to a study involving development and in vitro evaluation of sustained release pellets of ambroxol hydrochloride prepared by extrusion spheronization followed by fluid bed coating with the commercial aqueous polyvinyl acetate dispersion (Kollicoat SR 30 D); aqueous dispersion of ethyl acrylate and methyl methacrylate (Eudragit NE 30 D) and aqueous dispersion of acrylic and methacrylic acid esters (Eudragit RL 30 D and Eudragit RS 30 D). The release of ambroxol hydrochloride from coated pellets was investigated at different coating level. The release mechanism was explored and explained with zero order, first order, Higuchi equation and Korsmeyer's equation. The Mean Dissolution Time (MDT) value was calculated for all the formulations to determine the release retarding ability of the polymers. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer load and physico-chemical nature of the drug. This book will be helpful for the students and researchers of pharmacy discipline specially those who are engaged or interested in research related to modified release pellets dosage forms.

Author: Ajit S Narang
Publisher: Springer
ISBN: 3319202065
Category : Medical
Languages : en
Pages : 700

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Book Description
In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.