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Author: S.C. Maheshwari Publisher: Avichal Publishing Company ISBN: 8177394215 Category : Languages : en Pages : 120
Book Description
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
Author: S.C. Maheshwari Publisher: Avichal Publishing Company ISBN: 8177394215 Category : Languages : en Pages : 120
Book Description
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
Author: Boris Kovalerchuk Publisher: Springer ISBN: 3319730401 Category : Technology & Engineering Languages : en Pages : 332
Book Description
This book combines the advantages of high-dimensional data visualization and machine learning in the context of identifying complex n-D data patterns. It vastly expands the class of reversible lossless 2-D and 3-D visualization methods, which preserve the n-D information. This class of visual representations, called the General Lines Coordinates (GLCs), is accompanied by a set of algorithms for n-D data classification, clustering, dimension reduction, and Pareto optimization. The mathematical and theoretical analyses and methodology of GLC are included, and the usefulness of this new approach is demonstrated in multiple case studies. These include the Challenger disaster, world hunger data, health monitoring, image processing, text classification, market forecasts for a currency exchange rate, computer-aided medical diagnostics, and others. As such, the book offers a unique resource for students, researchers, and practitioners in the emerging field of Data Science.
Author: S.C. Maheshwari Publisher: Avichal Publishing Company ISBN: 817739374X Category : Languages : en Pages : 144
Book Description
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
Author: Clarisa Beatriz Palatnik-de-Sousa Publisher: Frontiers Media SA ISBN: 288945522X Category : Antigens Languages : en Pages : 284
Book Description
Since variolation, conventional approaches to vaccine development are based on live-attenuated, inactivated or purified pathogen-derived components. However, effective vaccines against global health threats such as HIV, parasite infections and tumors are difficult to achieve. On the other hand, synthetic vaccines based on immunogenic epitopes offer advantages over traditional vaccines since they are chemically defined antigens free from deleterious effects. Additionally, in contrast to live-attenuated vaccines, they do not revert to virulence in immunocompromised subjects, and different from genetic vaccines, they do not involve ethical questions. Traditional vaccines contain PAMPs and induce strong immune responses, while recombinant vaccines are less potent. In spite of the immunogenic weakness previously attributed to epitope-based vaccines a synthetic vaccine containing a 17 amino acid-epitope of the Pseudomonas aeruginosa Type IV pilus exceeded the protective potential of its cognate protein composed of 115 amino acids. Therefore, the efficacy yield of a synthetic vaccine can be potentiated by using the proper combination of target epitopes. Recent advances in adjuvant development, immunogen platforms for DNA vaccines and viral vectors also contributed to optimize immunogenicity. Another constraint to the use of epitope vaccines was their restriction to some MHC or HLA phenotypes. However, epitopes containing 20 or less amino acids of Plasmodium falciparum and Leishmania donovani bind to multiple HLA-DR and MHC receptors. Thus synthetic epitope vaccines may better meet the requirements of the regulatory agencies since they have lower costs and are easier to produce. The classical experimental approach for the development of an epitope-based vaccine involves the use of recombinant domains or overlapping 15-mer peptides spanning the full length of the target antigen, and the analysis of the induced antibody and/or T cell immune responses in vitro or in vivo. On the other hand, in silico tools can select peptides that are more likely to contain epitopes, reducing the number of sequence candidates. T cell epitope prediction dates back to 1980s, when the first algorithm was developed based on the identification of amphipathic helical regions on protein antigens. Since then, new methods based on MHC peptide-binding motifs or MHC-binding properties have been developed. The recent reverse vaccinology concept uses high-throughput genome sequencing and bioinformatics tools to identify potential targets of immune responses. The feasibility of this approach was shown for the first time in the design of a vaccine against Neisseria meningitides that is now in phase III clinical trials. In addition, different computational tools allow the determination of crucial gene(s) through comparative analyses between different pathogenic strains Alternatively, carbohydrates have been considered as key targets in developing safe and effective vaccines to combat cancer, bacterial and viral infections. Tumor associated carbohydrate antigens can be coupled covalently to protein carriers to target MHC receptors and improve immunogenicity and have reached already pre-clinical and clinical studies. In light of the recent availability of genomic tools, we believe that in the near future an increasing number of vaccine candidates, composed of defined epitopes, will be available for synthetic vaccines showing improved protection.
Author: Janet M. Decker Publisher: John Wiley & Sons ISBN: 1444313185 Category : Science Languages : en Pages : 190
Book Description
The 11th Hour Series of revision guides are designed for quick reference. The organization of these books actively involves studetns in the learning process and reinforces concepts. At the end of each chapter there is a test including multiple choice questions, true/false questions and short answer questions, and every answer involves an explanation. Each book contains icons in the text indicating additional support on a dedicated web page. Students having difficulties with their courses will find this an excellent way to raise their grades. Clinical correlations or everyday applications include examples from the real world to help students understand key concepts more readily. Dedicated web page, there 24 hours a day, will give extra help, tips, warnings of trouble spots, extra visuals and more. A quick check on what background students will need to apply helps equip them to conquer a topic. The most important information is highlighted and explained, showing the big picture and eliminating the guesswork. After every topic and every chapter, lots of opportunity for drill is provided in every format, multiple choice, true/false, short answer, essay. An easy trouble spot identifier demonstrates which areas need to be reinforced and where to find information on them. Practice midterms and finals prep them for the real thing.
Author: S.C. Maheshwari Publisher: Avichal Publishing Company ISBN: 8177393758 Category : Languages : en Pages : 152
Book Description
The early schooling years in a child’s life are of extreme importance. These are the times when he focuses his eyes and mind on everything that is new and appealing. His mind is untrained and he has learned only the basics of communication. His vocabulary is limited but he is eager to learn.Whatever is presented to him, he absorbs like a sponge. His attention span is short and he requires constant reinforcement. What interests him most is things and events around him. This is the golden opportunity to inculcate in him a spirit of adventure and inquiry, to teach him to ask, to reason and to pick up healthy habits. With this in mind our publisher decided to bring out a science series for the junior classes.
Author: Firas H. Kobeissy Publisher: CRC Press ISBN: 1466565993 Category : Medical Languages : en Pages : 718
Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: Gerald Brandacher Publisher: Humana Press ISBN: 1493920715 Category : Science Languages : en Pages : 404
Book Description
This volume presents a comprehensive overview of the latest advances in basic and translational research in the field of reconstructive transplantation and its potential therapeutic implications. Dr. Thomas E. Starzl and Dr. Raimund Margreiter, both pioneers in the field of transplantation, have written the foreword for the book. The volume spans such topics as skin rejection, immune monitoring, stem cell-based immunomodulatory strategies, costimulatory blockade, tolerance induction, chronic rejection, ischemia reperfusion injury, nerve regeneration, cortical reintegration, and small and large animal models for reconstructive transplantation. The book is intended for biomedical researchers and basic scientists in the field of reconstructive transplantation, transplant immunology and regenerative medicine, as well as clinicians, surgeons and multidisciplinary specialists, who are practicing or interested in this novel and exciting field. Postgraduate fellows and students will also find it a valuable reference.
Author: Mansoor M. Amiji Publisher: Academic Press ISBN: 0323909256 Category : Medical Languages : en Pages : 590
Book Description
Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Comprehensive treaty covering all aspects of immuno-oncology (IO) - Novel strategies for delivery of IO therapeutics and vaccines - Forecasting on the future of nanotechnology and drug delivery for IO
Author: Gordon MacPherson Publisher: John Wiley & Sons ISBN: 352767313X Category : Science Languages : en Pages : 373
Book Description
Knapp und präzise erklärt dieses einführende Lehrbuch der Immunologie die Funktion des Immunsystems anhand sorgfältig ausgewählter Beispiele aus der klinischen Praxis und dem Experiment. Von Büchern mit ähnlichem Themenspektrum unterscheidet es sich durch den klar evidenzbasierten Ansatz. Die Autoren -- ein erfahrener Dozent und ein angesehener Forscher -- regen dabei stets zur kritischen Reflexion des gelernten Stoffs an. Based on examples using clinical and experimental data, this concise introductory textbook provides an insight into the immune system, prompting readers to ask critical questions in order to further advance our understanding. Website: www.wiley-vch.de/home/immunology
Author: S.C. Maheshwari
Author: S.C. Maheshwari
Author: Boris Kovalerchuk
Author: S.C. Maheshwari
Author: Clarisa Beatriz Palatnik-de-Sousa
Author: Janet M. Decker
Author: S.C. Maheshwari
Author: Firas H. Kobeissy
Author: Gerald Brandacher
Author: Mansoor M. Amiji
Author: Gordon MacPherson