Antioxidants and Cardiovascular Disease PDF Download

Author: R Nath
Publisher: ALPHA SCIENCE INTERNATIONAL LIMITED
ISBN: 8184872879
Category : Medical
Languages : en
Pages : 325

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Book Description
This unique book authored by leading investigators in the field of Cardiovascular research and practicing clinicians across the globe details the scientific evidence for the heath effect of vitamins, antioxidants, trace elements and functional food, specifically their role in Cardiovascular system and provides up-to-date recommendations in the area of Cardiovascular nutrition including dietary micronutrients and supplements.Genetics of coronary disease as well as racial differences and risk factors, the role of Homocystine dietary fats, importance of antioxidant trace elements, genetic and racial differences especially in relation to cardiovascular effects, Clinical relevance of trace elements and minerals such as Chromium, Copper, Fluoride, Iron, Iodine, Molybdenum, Manganese, Selenium, Zinc, Calcium, Magnesium and Phosphorous have all been covered in relation to cardiovascular disease.

Author: Sajal Chakraborti
Publisher: Springer Nature
ISBN: 9811382735
Category : Science
Languages : en
Pages : 596

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Book Description
This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Author: John F. Keaney Jr.
Publisher: Springer Science & Business Media
ISBN: 9780792386780
Category : Medical
Languages : en
Pages : 404

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Book Description
One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.

Author: Jean-Claude Tardif
Publisher: Springer Science & Business Media
ISBN: 9780792365648
Category : Antioxidants
Languages : en
Pages : 320

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Book Description
This work addresses a complex problem in cardiovascular medicine. It is written by experts in the fields of atherosclerosis, heart failure, and antioxidants. It should be of interest not only to academicians but also to practising physicians, including postdoctoral fellows, internists, cardiologists, and general practitioners. The first three chapters review the antioxidant hypothesis and its close relationship to lipid mechanisms of action and classify the different and heterogeneous pharmacological compounds with known antioxidant properties, and describe the role of dietary nutrients and supplements as well as the potential therapeutic benefit of antioxidants in coronary artery disease prevention and risk reduction, prevention of endothelial dysfunction, and prevention of chronic heart failure. Finally, current knowledge of the use of these compounds in cardiovascular medicine is summarized.

Author: Sajal Chakraborti
Publisher: Springer Nature
ISBN: 9811389462
Category : Science
Languages : en
Pages : 686

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Book Description
This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.

Author: Martial G. Bourassa
Publisher: Springer
ISBN: 9780387510262
Category : Medical
Languages : en
Pages : 0

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Book Description
Chronic oxidative stress is associated with the aging process and often leads to the development of disorders such as cancer and arterial disease. Cardiovascular conditions in which oxidation damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive heart failure. Antioxidants and Cardiovascular Disease, Second Edition covers three major topics: 1) the first seven chapters review the oxidative modifcation hypothesis and its close relationship to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the next four chapters describe the different compounds, nutrients and supplements with antioxidant properties and their mechanisms of action; 3) and finallly, the last ten chapters discuss the potential benefits of antioxidants in overall cardiovascular prevention, including hypertension, diabetes mellitus, dyslipidemias, and in the treatment and prevention of specific conditions such as chronic coronary artery disease, restenosis after percutaneous coronary intervention, and chronic heart failure. Antioxidants and Cardiovascular Disease, Second Edition is written by recognized experts in the fields of atherosclerosis, heart failure and antioxidants. It should be of interest to medical students and fellows, researchers, and practicing physicians. There has been rapid progress in our knowledge in this field during the last two to three years. Thus the current reedition appears timely. For instance, this second edition captures several recently reported and published clinical trials as welll as new information on diabetic and hypertensive cardiovascular disease.

Author: Philip B Oliva
Publisher: World Scientific
ISBN: 9814602345
Category : Science
Languages : en
Pages : 631

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Book Description
This book covers two known controversial topics — antioxidants and stem cells as therapies to treat coronary heart disease. Aiming to provide college-educated but not scientifically trained readership with a wealth of information about these two cutting-edge technologies, Antioxidants and Stem Cells for Coronary Heart Disease is written with minimum scientific terminology. Basic science studies and clinical trials regarding stem cells and antioxidants are discussed and peppered with anecdotes to make them understandable and entertaining to the laymen.

Author: Antonis Zampelas
Publisher: CRC Press
ISBN: 1466580119
Category : Medical
Languages : en
Pages : 340

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Book Description
Antioxidant use in health promotion and disease prevention either through dietary intake or supplementation is controversial. This book reviews the latest evidence-based research in the area, principally through prospective cohort studies and randomized controlled trials. It assesses major dietary antioxidants and discusses their use in diseases such as cancer, diabetes, stroke, coronary heart disease, HIV/AIDS, and neurodegenerative and immune diseases. The use of antioxidants in health is also discussed along with common adverse effects associated with antioxidant use.

Author: J T Kumpulainen
Publisher: Elsevier
ISBN: 0857093053
Category : Medical
Languages : en
Pages : 462

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Book Description
Natural antioxidants and food quality in atherosclerosis and cancer prevention provides a comprehensive and up-to-date overview of the role of natural antioxidants and lipid peroxidation in atherosclerosis and cancer. The book presents important information on the presence of various flavonoids found in berries, vegetables and fruits and their antioxidative potencies, as well as the role of antioxidative vitamins and carotenoids in cardiovascular diseases and cancer. In addition, the measurement of oxidative stress in humans is surveyed.

Author: Barry Halliwell
Publisher: Oxford University Press
ISBN: 0198717474
Category : Medical
Languages : en
Pages : 961

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Book Description
Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.